Cas no 79-44-7 (N,N-dimethylcarbamoyl chloride)

N,N-Dimethylcarbamoyl chloride (CAS 79-44-7) is a versatile reagent widely used in organic synthesis, particularly for the introduction of the dimethylcarbamoyl group. This acyl chloride derivative is highly reactive, enabling efficient amidation and esterification reactions. Its applications include the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. The compound’s reactivity and selectivity make it valuable for constructing carbamate and urea derivatives. Due to its moisture sensitivity, it requires careful handling under anhydrous conditions. N,N-Dimethylcarbamoyl chloride is favored for its consistent performance in high-purity reactions, though appropriate safety measures must be observed due to its corrosive and toxic nature.
N,N-dimethylcarbamoyl chloride structure
79-44-7 structure
Product Name:N,N-dimethylcarbamoyl chloride
CAS No:79-44-7
MF:C3H6ClNO
MW:107.538839817047
MDL:MFCD00000635
CID:34182
PubChem ID:87567335
Update Time:2025-05-22

N,N-dimethylcarbamoyl chloride Chemical and Physical Properties

Names and Identifiers

    • dimethylcarbamoyl chloride
    • DMCl
    • N,N-Dimethylcarbamoyl chloride
    • N,N-Dimethylchloroformamide
    • Dimethylcarbamyl chloride
    • N,N-dimethyl carbamyl chloride
    • Dimethylcarbamic chloride
    • dimethylaminocarbamoyl chloride
    • dimethyl-carbamicaci
    • Dimethylcarbamoyl
    • dmcc
    • DMCF
    • N,N-dimethylaminocarbonyl chloride
    • N,N-dimethyl-carbamic acid chloride
    • N.N-dimethylaminocarbamoyl chloride
    • rcrawastenumberu097
    • TL 389
    • Chloroformic acid dimethylamide
    • Dimethyl carbamyl chloride
    • 79-44-7
    • Dimethylcarbamidoyl chloride
    • CARBAMIC ACID,N,N-DIMETHYL,CHLORIDE
    • Dimethylcarbamoyl chloride [UN2262] [Corrosive]
    • N,N-Dimethylaminoformyl chloride
    • HSDB 2656
    • WLN: GVN1&1
    • DIMETHYLCARBAMOYL CHLORIDE [HSDB]
    • Dimethylcarbamoylchloride
    • dimethylaminocarbonyl chloride
    • C3H6ClNO
    • Dimethylchloroformamide
    • N,N-Dimethylcarbamidoyl chloride
    • Dimethyl carbamylchloride
    • ClC(O)N(CH3)2
    • DIMETHYLCARBAMOYL CHLORIDE [IARC]
    • Chlorid kyseliny dimethylkarbaminove [Czech]
    • CHEBI:82280
    • 22055-85-2
    • NSC 122671
    • NCGC00091795-01
    • NCGC00091795-02
    • Dimethylcarbamylchlorid
    • D0695
    • DCR (CHRIS Code)
    • dimethylcarbarnyl chloride
    • CCRIS 257
    • NCGC00254074-01
    • Chlorid kyseliny dimethylkarbaminove
    • dirnethylcarbamoyl chloride
    • Dimethylcarbamyl chloride, 98%
    • Carbamyl chloride,N-dimethyl-
    • N,N-Dimethylcarbamic acid chloride
    • N,N-dimethyl carbamoyl chloride
    • BBL027301
    • N,N-dimethyl-carbamic chloride
    • RCRA waste no. U097
    • Dimethylamid kyseliny chlormravenci
    • dimethyl-carbamoyl chloride
    • W-104263
    • NSC-122671
    • Dimethylkarbamoylchlorid [Czech]
    • N,N-dimethyl-carbamoyl chloride
    • Dimethylcarbamoyl chloride, purum, >=98.0% (AT)
    • Me2NCOCl
    • Tox21_201334
    • N,N-Dimethylcarbamyl chloride
    • CHEMBL1527556
    • SCHEMBL924
    • Chloroformic acid dimethyl amide
    • DTXCID30512
    • dimethylcarbamoylchlorid
    • dimethyl carbamic acid chloride
    • Carbamoyl chloride, dimethyl-
    • MFCD00000635
    • EINECS 201-208-6
    • Carbamic chloride, dimethyl-
    • NA2262
    • 5D54S95GT6
    • N,N-dimethyl-carbamoylchloride
    • Dimethylamid kyseliny chlormravenci [Czech]
    • Dimethylkarbamoylchlorid
    • (Dimethylamino)carbonyl chloride
    • UNII-5D54S95GT6
    • Dimethylaminoformyl chloride
    • NCGC00258886-01
    • Dimethylcarbamoyl chloride [UN2262] [Corrosive]
    • N,N-dimethylcarbamic chloride
    • AKOS000120154
    • dimethyl carbamoylchloride
    • NSC122671
    • EC 201-208-6
    • Dimetilcarbonile Cloruro
    • RCRA waste number U097
    • Carbamic chloride, N,N-dimethyl-
    • CAS-79-44-7
    • Carbamyl chloride, N,N-dimethyl-
    • FT-0629527
    • LS-1784
    • F0001-2079
    • Dimethylcarbamic acid chloride
    • Tox21_300116
    • Dimethyl carbamoyl chloride
    • DTXSID1020512
    • dimethylcarbamylchloride
    • Q2563907
    • C19175
    • UN2262
    • BRN 0878197
    • (CH3)2NCOCl
    • InChI=1/C3H6ClNO/c1-5(2)3(4)6/h1-2H
    • N,N-Dime thylcarbamyl Chloride
    • N,N-dimethylcarbamoylchloride
    • NCGC00091795-03
    • STL370332
    • NS00009845
    • Carbamic chloride, dimethyl- (9CI)
    • Carbamoyl chloride, dimethyl- (6CI, 7CI, 8CI)
    • N,N-Dimethylcarbamic chloride (ACI)
    • (N,N-Dimethylamino)carbonyl chloride
    • 1-Chloro-N,N-dimethylformamide
    • DIMETHYL CARBAMIC CHLORIDE
    • Dimethyl carbamoyl chloride (ACGIH)
    • N,NDimethylcarbamyl chloride
    • DIMETHYLCARBAMOYL CHLORIDE (IARC)
    • (ACGIH) UN2262
    • TL 389v
    • N,NDimethylcarbamic acid chloride
    • Carbamyl chloride, N,Ndimethyl
    • {ACGIH] UN2262
    • N,NDimethylcarbamidoyl chloride
    • carbamic chloride, dimethyl
    • Carbamicchloride
    • Carbamoyl chloride, dimethyl
    • N,NDimethylcarbamoyl chloride
    • N,N-dimethylcarbamoyl chloride
    • MDL： MFCD00000635
    • Inchi： 1S/C3H6ClNO/c1-5(2)3(4)6/h1-2H3
    • InChI Key： YIIMEMSDCNDGTB-UHFFFAOYSA-N
    • SMILES： O=C(N(C)C)Cl
    • BRN： 878197

Computed Properties

  • Exact Mass: 107.01400
  • Monoisotopic Mass: 107.014
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 6
  • Rotatable Bond Count: 1
  • Complexity: 61.8
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: 0.8
  • Topological Polar Surface Area: 20.3A^2

Experimental Properties

  • Color/Form: Colorless or light yellow to light brown irritant oily liquid
  • Density: 1.168?g/mL?at 25?°C(lit.)
  • Melting Point: ?33?°C (lit.)
  • Boiling Point: 167-168?°C/775?mmHg(lit.)
  • Flash Point: Fahrenheit: 179.6 ° f < br / > Celsius: 82 ° C < br / >
  • Refractive Index: n20/D 1.453(lit.)
  • Water Partition Coefficient: decomposition
  • PSA: 20.31000
  • LogP: 0.90680
  • Sensitiveness: Moisture Sensitive
  • Solubility: Soluble in ether, carbon disulfide, benzene and other organic solvents. It is not miscible with water.

N,N-dimethylcarbamoyl chloride Security Information

  • Symbol: GHS06 GHS08
  • Prompt：dangerous
  • Signal Word：Danger
  • Hazard Statement： H302,H315,H319,H331,H335,H350
  • Warning Statement： P201,P261,P305+P351+P338,P311
  • Hazardous Material transportation number：UN 2262 8/PG 2
  • WGK Germany：3
  • Hazard Category Code： 45-22-23-36/37/38
  • Safety Instruction： S53-S45
  • FLUKA BRAND F CODES：9
  • RTECS：FD4200000
  • Hazardous Material Identification： T
  • Safety Term：8
  • Packing Group：II
  • Risk Phrases：R45; R22; R23; R36/37/38
  • Packing Group：II
  • Hazard Level：8
  • HazardClass：8
  • PackingGroup：II
  • TSCA：Yes
  • Storage Condition：The storage location should be close to the place used in the laboratory, so only a small amount needs to be transported. Carcinogens should be stored in only one part of the storage area, explosion-proof cold storage or freezer. This area shall be properly marked. A list should show the number of carcinogens and the date of acquisition, and the equipment allocation should be adjacent to the storage area.

N,N-dimethylcarbamoyl chloride Pricemore >>

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N,N-dimethylcarbamoyl chloride Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Sodium hydroxide ;  2 min, heated
Reference
A novel and efficient strategy for the synthesis of various carbamates using carbamoyl chlorides under solvent-free and grinding conditions using microwave irradiation
Zare, Hassan; Ghanbari, Mohammad Mehdi; Jamali, Marzieh; Aboodi, Abdollah, Chinese Chemical Letters, 2012, 23(8), 883-886

Production Method 2

Reaction Conditions
1.1 Reagents: Chlorine Solvents: Dichloromethane ;  6 h, 24 - 26 °C; 20 min
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  2 - 3 h
Reference
Development of an improved method for conversion of thiuram disulfides into N,N-dialkylcarbamoyl halides and derivatives
Adeppa, K.; Rupainwar, D. C.; Misra, Krishna, Synthetic Communications, 2011, 41(2), 285-290

Production Method 3

Reaction Conditions
Reference
Reactivity of thionyl chloride
Cardillo, Paolo, Chimica e l'Industria (Milan), 1992, 74(12),

Production Method 4

Reaction Conditions
1.1 Reagents: Copper carbonate ,  Copper oxide (CuO) Solvents: Water
1.2 Solvents: Acetone ,  Water
1.3 Reagents: Hydrogen sulfide Solvents: Water
1.4 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol
1.5 Reagents: Hydrochloric acid Solvents: Water
1.6 Catalysts: L-Ornithine ,  2-Bromo-4-methyl-1-nitrobenzene Solvents: Acetic acid
Reference
A Comprehensive Study of the Active Site Residues of DT-Diaphorase: Rational Design of Benzimidazolediones as DT-Diaphorase Substrates
Suleman, Ali; Skibo, Edward B., Journal of Medicinal Chemistry, 2002, 45(6), 1211-1220

Production Method 5

Reaction Conditions
1.1 Reagents: Thionyl chloride
Reference
Preparation of carbamoyl chlorides (bromides) by reactions of phosphorus trichloride (bromide) and thionyl chloride (bromide) with formamides
Schindler, Norbert; Ploeger, Walter, Chemische Berichte, 1971, 104(3), 969-71

Production Method 6

Reaction Conditions
1.1 Reagents: Sodium bicarbonate Solvents: Dichloromethane ;  rt → 0 °C
1.2 Solvents: Dichloromethane ;  < 0 °C; 0 °C → rt; 6 - 8 h, rt
Reference
Synthesis and biological evaluation of genistein carbamate derivatives
Qiang, Xiaoming; Yuan, Wen; Sang, Zhipei; Deng, Yong, Youji Huaxue, 2013, 33(3), 621-629

Production Method 7

Reaction Conditions
1.1 Reagents: Sodium bicarbonate Solvents: Dichloromethane ;  0.5 h, -10 °C; -10 °C → rt; 6 - 8 h, rt
Reference
Synthesis of pterostilbene and resveratrol carbamate derivatives as potential dual cholinesterase inhibitors and neuroprotective agents
Yuan, Wen; Shang, Zhipei; Qiang, Xiaoming; Tan, Zhenghuai; Deng, Yong, Research on Chemical Intermediates, 2014, 40(2), 787-800

Production Method 8

Reaction Conditions
1.1 Reagents: Phosphorus oxychloride Solvents: Acetonitrile
Reference
A convenient preparation of certain N,N-dialkylcarbamoyl chlorides
Hoshino, Osamu; Saito, Keiji; Ishizaki, Miyuki; Umezawa, Bunsuke, Synthetic Communications, 1987, 17(16), 1887-92

Production Method 9

Reaction Conditions
1.1 Solvents: Dichloromethane ,  Pyridine ;  0 °C; 4 - 5 h, 0 °C
Reference
Design, synthesis, and pharmacokinetic evaluation of O-carbamoyl tizoxanide prodrugs
He, Xi; Hu, Wenjun; Meng, Fanhua; Li, Xingzhou, Medicinal Chemistry (Sharjah, 2022, 18(1), 140-150

Production Method 10

Reaction Conditions
1.1 Reagents: Thionyl chloride ;  4 h, rt → reflux
Reference
Discovery and Optimization of N-Acyl-6-sulfonamide-tetrahydroquinoline Derivatives as Novel Non-Steroidal Selective Glucocorticoid Receptor Modulators
Li, Dan ; Bao, Xiaodong; Pang, Jinping; Hu, Xueping; Wang, Longling; et al, Journal of Medicinal Chemistry, 2022, 65(23), 15710-15724

Production Method 11

Reaction Conditions
1.1 Reagents: Thionyl chloride ;  3 h, reflux
Reference
Design, synthesis and biological evaluation of dual acetylcholinesterase and phosphodiesterase 5A inhibitors in treatment for Alzheimer's disease
Zhou, Li-yun; Zhu, Yao; Jiang, Yu-ren; Zhao, Xiong-jie; Guo, Dong, Bioorganic & Medicinal Chemistry Letters, 2017, 27(17), 4180-4184

Production Method 12

Reaction Conditions
1.1 Reagents: Triethylamine Solvents: Dichloromethane
Reference
Novel Natural Product-like Caged Xanthones Bearing a Carbamate Moiety Exhibit Antitumor Potency and Anti-Angiogenesis Activity In vivo
Xu, Xiaoli; Wu, Yue; Hu, Mingyang; Li, Xiang; Bao, Qichao; et al, Scientific Reports, 2016, 6,

Production Method 13

Reaction Conditions
1.1 Solvents: Dichloromethane ;  40 °C; 3 h, reflux; reflux → rt
1.2 Reagents: Chlorine ;  140 min, rt
Reference
An improved one-pot cost-effective synthesis of N,N-disubstituted carbamoyl halides and derivatives
Adeppa, K.; Rupainwar, D. C.; Misra, Krishna, Canadian Journal of Chemistry, 2010, 88(12), 1277-1280

Production Method 14

Reaction Conditions
Reference
Synthesis and properties of (N,N-dimethyl)dichloromethaniminium chlorosulfate
Kukhar, V. P.; Pasternak, V. I.; Shevchenko, M. V., Zhurnal Organicheskoi Khimii, 1978, 14(9), 1841-6

Production Method 15

Reaction Conditions
1.1 Reagents: Sulfur dichloride Solvents: Dichloromethane ,  Pyridine
Reference
Chemistry of sulfur chlorides. II. Reaction of sulfur dichloride, disulfur dichloride, and sulfuryl chloride with (thio)amides to yield (thio)carbamoyl chlorides and mustard oils
Hasserodt, Ulrich, Chemische Berichte, 1968, 101(1), 113-20

Production Method 16

Reaction Conditions
1.1 Catalysts: Sodium hydroxide Solvents: Benzene ,  Xylene ,  Water ;  rt; 30 min, 70 °C
Reference
New aminoporphyrins bearing urea derivative substituents: synthesis, characterization, antibacterial and antifungal activity
Karimipour, Gholamreza; Kowkabi, Saeed; Naghiha, Asghar, Brazilian Archives of Biology and Technology, 2015, 58(3), 431-442

Production Method 17

Reaction Conditions
1.1 Reagents: Sulfur dichloride Solvents: Carbon tetrachloride
Reference
Method for the preparation of carbamoyl chlorides and process for their utilization in the preparation of substituted monoarylureas
, Spain, , ,

N,N-dimethylcarbamoyl chloride Raw materials

N,N-dimethylcarbamoyl chloride Preparation Products

N,N-dimethylcarbamoyl chloride Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:79-44-7)二甲氨基甲酰氯
Order Number:LE1755440;LE15176;LE5253
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:36
Price ($):discuss personally
Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:79-44-7)Dimethylcarbamoyl chloride
Order Number:sfd17157
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:37
Price ($):discuss personally

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Recommended suppliers
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:79-44-7)二甲氨基甲酰氯
LE1755440;LE15176;LE5253
Purity:99%/99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry/Inquiry
Email
Suzhou Senfeida Chemical Co., Ltd
(CAS:79-44-7)Dimethylcarbamoyl chloride
sfd17157
Purity:99.9%
Quantity:200kg
Price ($):Inquiry
Email