Production Method 1

111373-31-0

96606-95-0

Reaction Conditions

1.1 Reagents: Sodium chloride Solvents: Dimethyl sulfoxide ,  Water

Reference

Efficient palladium-mediated synthesis of a spirocyclic model for fredericamycin A

Ciufolini, Marco A.; Browne, Margaret E., Tetrahedron Letters, 1987, 28(2), 171-4

Production Method 2

141273-91-8

96606-95-0

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Ethanol ,  Water ;  2 h, reflux; cooled
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 2

Reference

Copper-catalyzed cross-coupling of O-alkyl hydroxamates with aryl iodides

Kukosha, Tatyana; Trufilkina, Nadezhda; Belyakov, Sergey; Katkevics, Martins, Synthesis, 2012, 44(15), 2413-2423

Production Method 3

2033-24-1

26260-02-6

96606-95-0

Reaction Conditions

1.1 Reagents: Formic acid ,  Triethylamine

Reference

The photo-dehydro-Diels-Alder (PDDA) reaction - a powerful method for the preparation of biaryls

Wessig, Pablo; Mueller, Gunnar; Pick, Charlotte; Matthes, Annika, Synthesis, 2007, (3), 464-477

Production Method 4

111373-31-0

96606-95-0

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Water ;  overnight, reflux; overnight, reflux

Reference

A preparation of oxyphenyl and sulfanylphenyl derivatives of amino acids, useful as glycine transporter inhibitors

, World Intellectual Property Organization, , ,

Production Method 5

90276-19-0

96606-95-0

Reaction Conditions

1.1 Reagents: Guanidine nitrate ,  Oxygen ,  Hydrazine hydrate (1:1) Solvents: Ethanol ,  Ethyl acetate ;  16 h, rt; 16 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 1, rt

Reference

Synthetic Studies Toward the Skyllamycins: Total Synthesis and Generation of Simplified Analogues

Giltrap, Andrew M.; Haeckl, F. P. Jake; Kurita, Kenji L.; Linington, Roger G. ; Payne, Richard J., Journal of Organic Chemistry, 2018, 83(13), 7250-7270

Production Method 6

96606-95-0

Reaction Conditions

Reference

The Endocyclic Restriction Test: An Investigation of the Geometries of Thiophilic Additions of Aryl Radicals and Aryllithium Reagents to Dithioesters

Beak, Peter; Park, Yong Sun; Reif, Lee A.; Liu, Chao, Journal of Organic Chemistry, 1994, 59(24), 7410-13

Production Method 7

501-52-0

96606-95-0

1643-29-4

Reaction Conditions

1.1 Reagents: N-Iodosuccinimide ,  Sulfuric acid Solvents: Acetic acid

Reference

Iodination of aromatic compounds by N-iodosuccinimide in organic solvents in the presence of H2SO4

Chaikovski, V. K.; Filimonov, V. D.; Skorokhodov, V. I., Izvestiya Vysshikh Uchebnykh Zavedenii, 2002, 45(3), 48-51

Production Method 8

128823-38-1

96606-95-0

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Methanol ,  Water ;  overnight, reflux; reflux → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  rt

Reference

Carbopalladation of Nitriles: Synthesis of Benzocyclic Ketones and Cyclopentenones via Pd-Catalyzed Cyclization of ω-(2-Iodoaryl)alkanenitriles and Related Compounds

Pletnev, Alexandre A.; Larock, Richard C., Journal of Organic Chemistry, 2002, 67(26), 9428-9438

Production Method 9

2033-24-1

26260-02-6

96606-95-0

Reaction Conditions

1.1 Reagents: Formic acid ,  Triethylamine Solvents: Dimethylformamide ;  0 °C; 12 h, 65 °C
1.2 Reagents: Water ;  6 h, 90 °C

Reference

Palladium-Catalyzed, Norbornene-Mediated, ortho-Amination ipso-Amidation: Sequential C-N Bond Formation

Whyte, Andrew ; Olson, Maxwell E.; Lautens, Mark, Organic Letters, 2018, 20(2), 345-348

Production Method 10

2033-24-1

26260-02-6

96606-95-0

Reaction Conditions

1.1 Reagents: Formic acid, compd. with N,N-diethylethanamine (5:2)

Reference

The effect of vinyl esters on the enantioselectivity of the lipase-catalyzed transesterification of alcohols

Kawasaki, M.; Goto, M.; Kawabata, S.; Kometani, T., Tetrahedron: Asymmetry, 2001, 12(4), 585-596

Production Method 11

2033-24-1

26260-02-6

96606-95-0

Reaction Conditions

1.1 Reagents: Formic acid ,  Formic acid, compd. with N,N-diethylethanamine (5:2)

Reference

On Homogeneous Gold/Palladium Catalytic Systems

Hashmi, A. Stephen K.; Lothschuetz, Christian; Doepp, Rene; Ackermann, Martin; Becker, Janosc De Buck; et al, Advanced Synthesis & Catalysis, 2012, 354(1), 133-147

Production Method 12

26260-02-6

126-81-8

96606-95-0

Reaction Conditions

Reference

Copper-Catalyzed Dynamic Kinetic C-P Cross-Coupling/Cyclization for the Concise Asymmetric Synthesis of Six-, Seven- and Eight-Membered P-Stereogenic Phosphorus Heterocycles

Li, Yanli; Jin, Xiao; Liu, Peng; Zhang, Haijuan; Yu, Xiuling; et al, Angewandte Chemie, 2022, 61(24),

Production Method 13

1643-34-1

96606-95-0

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium

Reference

Phosphine-catalyzed divergent domino processes between γ-substituted allenoates and carbonyl-activated alkenes

Wu, Mingyue; Han, Zhaobin; Ni, Huanzhen; Wang, Nengzhong; Ding, Kuiling; et al, Chemical Science, 2022, 13(11), 3161-3168

Production Method 14

96606-95-0

Reaction Conditions

Reference

An Approach to Lysergic Acid Utilizing an Intramolecular Isomuenchnone Cycloaddition Pathway

Marino, Joseph P. Jr.; Osterhout, Martin H.; Padwa, Albert, Journal of Organic Chemistry, 1995, 60(9), 2704-13

3-(2-Iodophenyl)propanoic Acid Raw materials

• 3-Phenylpropionic acid
• 2,2-dimethyl-1,3-dioxane-4,6-dione
• Benzenepropanenitrile, 2-iodo-
• Diethyl 2-(2-iodobenzyl)malonate
• 2-Iodobenzaldehyde
• 5,5-dimethylcyclohexane-1,3-dione
• 2-Propenoic acid, 3-(2-iodophenyl)-, (E)-
• Benzenepropanoic acid, 2-iodo-, methyl ester
• 2-Propenoic acid,3-(2-iodophenyl)-

3-(2-Iodophenyl)propanoic Acid Preparation Products

• 3-(2-Iodophenyl)propanoic Acid (96606-95-0)
• 3-(4-Iodophenyl)propanoic acid (1643-29-4)

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• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Phenylpropanoic acids Phenylpropanoic acids
• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Phenylpropanoic acids

• 90036-64-9(Benzenepentadecanoic acid, 2-iodo-)
• 80479-93-2(Benzenepentadecanoicacid, 4-iodo-)
• 74674-85-4(Benzenepentadecanoicacid, 2-(iodo-131I)- (9CI))
• 1643-29-4(3-(4-Iodophenyl)propanoic acid)
• 74855-17-7(Benzenepentadecanoicacid, 4-(iodo-123I)- (9CI))
• 106181-24-2(Benzenehexadecanoic acid, 4-iodo-)
• 141273-91-8(Benzenepropanoic acid, 2-iodo-, methyl ester)
• 68034-75-3(3-(3-Iodophenyl)propanoic acid)
• 27913-58-2(4-(p-Iodophenyl)butyric acid)
• 85578-85-4(14-(iodophenyl)-3-methyltetradecanoic acid)