- Iodination of aromatic compounds by N-iodosuccinimide in organic solvents in the presence of H2SO4Chaikovski, V. K.; Filimonov, V. D.; Skorokhodov, V. I., Izvestiya Vysshikh Uchebnykh Zavedenii, 2002, 45(3), 48-51
Cas no 1643-29-4 (3-(4-Iodophenyl)propanoic acid)
3-(4-Iodophenyl)propanoic acid is a versatile aromatic carboxylic acid derivative, characterized by the presence of an iodine substituent on the phenyl ring. This compound is particularly valuable in organic synthesis and pharmaceutical research due to its reactive iodophenyl group, which facilitates cross-coupling reactions such as Suzuki or Heck reactions. The propanoic acid moiety further enhances its utility as a building block for modifying molecular structures. Its stability and well-defined reactivity make it suitable for applications in medicinal chemistry, material science, and as an intermediate in the synthesis of more complex compounds. The product is typically supplied in high purity, ensuring consistent performance in research and industrial applications.
1643-29-4 structure
Product Name:3-(4-Iodophenyl)propanoic acid
CAS No:1643-29-4
MF:C9H9IO2
MW:276.071035146713
MDL:MFCD00017597
CID:41728
PubChem ID:233238
Update Time:2025-07-28
3-(4-Iodophenyl)propanoic acid Chemical and Physical Properties
Names and Identifiers
-
- 3-(4-Iodophenyl)propionic acid
- 3-(4-iodophenyl)propanoic acid
- 4-Iodohydrocinnamic acid
- 3-(4-Iodphenyl)propionsSre
- 4-Iodo-benzenepropanoic acid
- 3-(4-Iodphenyl)propionicacid
- Benzenepropanoic acid, 4-iodo-
- NSC31595
- 4-Iodobenzenepropanoic acid
- 4-(Iodohydro)cinnamic acid
- Benzenepropanoic acid,4-iodo-
- 3-(4'-iodophenyl)propanoic acid
- 3-(4'-Iodophenyl)propionic acid
- SJMRZGIIQIWIFS-UHFFFAOYSA-N
- SBB052832
- RP0
- FT-0600353
- SCHEMBL1007160
- MFCD00017597
- A810557
- EN300-139919
- W-205934
- NSC-31595
- PS-7248
- 1643-29-4
- 3-(4-iodophenyl)propanoicacid
- CS-0157511
- SY016883
- DTXSID90283446
- AMY10997
- AKOS009159241
- DB-006240
- 674-698-6
- DTXCID70234597
- 3-(4-Iodophenyl)propanoic acid
-
- MDL： MFCD00017597
- Inchi： 1S/C9H9IO2/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-2,4-5H,3,6H2,(H,11,12)
- InChI Key： SJMRZGIIQIWIFS-UHFFFAOYSA-N
- SMILES： IC1C=CC(=CC=1)CCC(=O)O
Computed Properties
- Exact Mass: 275.96500
- Monoisotopic Mass: 275.965
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 12
- Rotatable Bond Count: 3
- Complexity: 151
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: 2.5
- Topological Polar Surface Area: 37.3
Experimental Properties
- Density: 1.8±0.1 g/cm3
- Melting Point: 140-142°C
- Boiling Point: 335.4°C at 760 mmHg
- Flash Point: 156.7±20.9 °C
- Refractive Index: 1.624
- PSA: 37.30000
- LogP: 2.30840
- Vapor Pressure: 0.0±0.8 mmHg at 25°C
3-(4-Iodophenyl)propanoic acid Security Information
- Signal Word：Warning
- Hazard Statement： H302-H315-H319-H335
- Warning Statement： P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501
- Safety Instruction： H303+H313+H333
-
Hazardous Material Identification：
- HazardClass：IRRITANT
- Storage Condition：Keep in dark place,Sealed in dry,2-8°C
3-(4-Iodophenyl)propanoic acid Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Fluorochem | 033922-1g |
3-(4-Iodophenyl)propionic acid |
1643-29-4 | 98% | 1g |
￡36.00 | 2022-03-01 | |
| Fluorochem | 033922-10g |
3-(4-Iodophenyl)propionic acid |
1643-29-4 | 98% | 10g |
￡143.00 | 2022-03-01 | |
| Fluorochem | 033922-25g |
3-(4-Iodophenyl)propionic acid |
1643-29-4 | 98% | 25g |
￡342.00 | 2022-03-01 | |
| Alichem | A013034428-250mg |
3-(4'-Iodophenyl)propionic acid |
1643-29-4 | 97% | 250mg |
484.80 USD | 2021-06-22 | |
| Alichem | A013034428-500mg |
3-(4'-Iodophenyl)propionic acid |
1643-29-4 | 97% | 500mg |
782.40 USD | 2021-06-22 | |
| Alichem | A013034428-1g |
3-(4'-Iodophenyl)propionic acid |
1643-29-4 | 97% | 1g |
1,460.20 USD | 2021-06-22 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | 007468-5g |
3-(4-Iodophenyl)propanoic acid |
1643-29-4 | 98% | 5g |
4421.0CNY | 2021-07-10 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | 007468-1g |
3-(4-Iodophenyl)propanoic acid |
1643-29-4 | 98% | 1g |
990.0CNY | 2021-07-10 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | B-UK749-200mg |
3-(4-Iodophenyl)propanoic acid |
1643-29-4 | 98% | 200mg |
63.0CNY | 2021-07-10 | |
| Apollo Scientific | OR6478-250mg |
3-(4-Iodophenyl)propanoic acid |
1643-29-4 | 250mg |
￡16.00 | 2025-02-20 |
3-(4-Iodophenyl)propanoic acid Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: N-Iodosuccinimide , Sulfuric acid Solvents: Acetic acid
Reference
3-(4-Iodophenyl)propanoic acid Raw materials
3-(4-Iodophenyl)propanoic acid Preparation Products
3-(4-Iodophenyl)propanoic acid Related Literature
-
Chao Wang,Genbin Shi,Xinhua Ji Med. Chem. Commun. 2018 9 1818
-
Rajesh Sahu,Saurav Yadav,Suvadeep Nath,Joydeep Banerjee,Anant R. Kapdi Chem. Commun. 2023 59 6128
Additional information on 3-(4-Iodophenyl)propanoic acid
Introduction to 3-(4-Iodophenyl)propanoic acid (CAS No. 1643-29-4)
3-(4-Iodophenyl)propanoic acid, identified by the Chemical Abstracts Service Number (CAS No.) 1643-29-4, is a significant compound in the realm of pharmaceutical and biochemical research. This molecule, featuring a propanoic acid moiety attached to a 4-iodophenyl group, has garnered attention due to its versatile applications in synthetic chemistry and drug development. The presence of the iodine atom on the aromatic ring enhances its reactivity, making it a valuable intermediate in various chemical transformations.
The structural characteristics of 3-(4-Iodophenyl)propanoic acid contribute to its utility in medicinal chemistry. The combination of the iodophenyl group and the carboxylic acid functionality allows for diverse modifications, enabling researchers to explore novel pharmacophores. This compound has been extensively studied for its potential in designing molecules with therapeutic properties, particularly in the context of small-molecule drug discovery.
Recent advancements in the field have highlighted the role of 3-(4-Iodophenyl)propanoic acid in the development of targeted therapies. Its structural motif is reminiscent of several bioactive molecules that have shown promise in preclinical studies. The iodine substituent, in particular, facilitates palladium-catalyzed cross-coupling reactions, which are pivotal in constructing complex organic frameworks. These reactions are widely employed in the synthesis of pharmaceuticals, including antiviral and anticancer agents.
In addition to its synthetic utility, 3-(4-Iodophenyl)propanoic acid has been investigated for its biological activity. Studies suggest that derivatives of this compound may exhibit inhibitory effects on certain enzymes and receptors, making them candidates for further development as therapeutic agents. The carboxylic acid group provides a site for further functionalization, allowing for the introduction of additional pharmacological moieties. This flexibility has made 3-(4-Iodophenyl)propanoic acid a cornerstone in the design of novel drug candidates.
The compound's reactivity also makes it a valuable tool in biochemical research. Researchers have utilized 3-(4-Iodophenyl)propanoic acid to study enzyme mechanisms and probe protein-ligand interactions. Its ability to undergo selective modifications has enabled the creation of probes that can be used to investigate biological pathways. Such studies are crucial for understanding disease mechanisms and developing effective treatments.
One notable application of 3-(4-Iodophenyl)propanoic acid is in the synthesis of radiolabeled compounds for diagnostic imaging. The iodine atom can be easily incorporated into radioactive isotopes, such as iodine-125 or iodine-131, which are used in positron emission tomography (PET) scans. These radiolabeled derivatives have been employed to visualize biological processes and monitor therapeutic responses in patients.
The chemical properties of 3-(4-Iodophenyl)propanoic acid also make it suitable for material science applications. Its ability to form stable complexes with metals has led to its use in catalytic systems and coordination chemistry research. These applications underscore the compound's broad utility beyond traditional pharmaceutical contexts.
In conclusion, 3-(4-Iodophenyl)propanoic acid (CAS No. 1643-29-4) is a multifaceted compound with significant implications in pharmaceutical research and beyond. Its structural features enable diverse chemical transformations and biological investigations, making it an indispensable tool for scientists working on drug discovery and material science. As research continues to uncover new applications for this compound, its importance is likely to grow further.
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