Production Method 1

6334-18-5

96516-31-3

Reaction Conditions

1.1 Reagents: Potassium fluoride Catalysts: Tetraphenylphosphonium bromide ,  Tetraspiro[21,22,23,24-tetraoxapentacyclo[16.2.1.13,6.18,11.113,16]tetracosa-3,5… Solvents: 3,4-Dichlorotoluene ;  2 h, 213 °C

Reference

Halogen-exchange fluorination of chlorinated benzaldehydes and diphenyl ketones promoted by microwave

Liang, Zhengyong; Lu, Chun-xu, Advanced Materials Research (Durnten-Zurich, 2011, 266, 292-295

Production Method 2

96516-31-3

Reaction Conditions

Reference

Preparation of dihydropyrimidine derivatives and uses thereof in the treatment of HBV infection or of HBV-induced diseases

, World Intellectual Property Organization, , ,

Production Method 3

102940-86-3

96516-31-3

Reaction Conditions

1.1 Reagents: (T-4)-Trihydro(tetrahydrofuran)boron Solvents: Tetrahydrofuran ;  0 °C; overnight, reflux; cooled
1.2 Reagents: Hydrochloric acid Solvents: Ethyl acetate ,  Water
1.3 Reagents: Dimethyl sulfoxide ,  Oxalyl chloride Solvents: Dichloromethane ;  5 min, -78 °C
1.4 Solvents: Dichloromethane ;  -78 °C; 1 h, -40 °C
1.5 Reagents: Triethylamine ;  -40 °C → rt

Reference

Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors

Ichikawa, Masanori; Yokomizo, Aki; Itoh, Masao; Usui, Hiroyuki; Shimizu, Hironari; et al, Bioorganic & Medicinal Chemistry, 2011, 19(6), 1930-1949

Production Method 4

116850-28-3

96516-31-3

Reaction Conditions

1.1 Reagents: Chromium trioxide

Reference

Synthesis and antihypertensive activity of 1,4-dihydropyridine derivatives with a 4-(disubstituted phenyl) ring and an aminoalkyl ester group: highly potent and long-lasting calcium antagonists

Kanno, Hideo; Yamaguchi, Hisao; Okamiya, Yoshiaki; Sunakawa, Kiyotaka; Takeshita, Toru; et al, Chemical & Pharmaceutical Bulletin, 1992, 40(8), 2049-54

Production Method 5

96516-31-3

Reaction Conditions

Reference

Design, Synthesis, and Evaluation of Tetrahydropyrrolo[1,2-c]pyrimidines as Capsid Assembly Inhibitors for HBV Treatment

Li, Xiaolin; Zhou, Kai; He, Haiying; Zhou, Qiong; Sun, Ya; et al, ACS Medicinal Chemistry Letters, 2017, 8(9), 969-974

Production Method 6

96516-31-3

Reaction Conditions

Reference

Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors [Erratum to document cited in CA154:564965]

Ichikawa, Masanori; Yokomizo, Aki; Itoh, Masao; Usui, Hiroyuki; Shimizu, Hironari; et al, Bioorganic & Medicinal Chemistry, 2014, 22(11),

Production Method 7

96516-31-3

Reaction Conditions

Reference

1,4-Dihydropyridines

, Japan, , ,

Production Method 8

96516-31-3

Reaction Conditions

Reference

Dihydropyridinedicarboxylate cardiovascular agents

, European Patent Organization, , ,

Production Method 9

96516-31-3

Reaction Conditions

Reference

Halonitrobenzaldehyde derivatives

, Japan, , ,

Production Method 10

96516-31-3

Reaction Conditions

Reference

1,4-Dihydropyridine derivatives, and their pharmaceutical use

, European Patent Organization, , ,

2-Chloro-3-fluorobenzaldehyde Raw materials

• 2-chloro-3-fluorotoluene
• 2-Chloro-3-fluorobenzoic acid
• 2,3-Dichlorobenzaldehyde

2-Chloro-3-fluorobenzaldehyde Preparation Products

• 2-Chloro-3-fluorobenzaldehyde (96516-31-3)

• 1. Excellent humidity sensor based on ultrathin HKUST-1 nanosheets?
  Qiaoe Wang,Meiling Lian,Xiaowen Zhu,Xu Chen RSC Adv., 2021,11, 192-197
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• 3. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
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• 4. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 5. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoyl derivatives
• Solvents and Organic Chemicals Organic Compounds Aldehyde/Ketone

• 84194-30-9(2-Chloro-5-Fluorobenzaldehyde)
• 1261561-82-3(2-chloro-3,5-difluorobenzaldehyde)
• 178813-77-9(2,6-Dichloro-3-fluorobenzaldehyde)
• 1182709-86-9(2,6-Dichloro-4-fluorobenzaldehyde)
• 261762-39-4(2-Chloro-3,6-difluorobenzaldehyde)
• 165047-23-4(2-Chloro-4,5-difluorobenzaldehyde)
• 86522-91-0(2,4-Dichloro-5-fluorobenzaldehyde)
• 84194-36-5(2-Chloro-4-fluorobenzaldehyde)
• 5527-95-7(4-Chloro-3-Fluorobenzaldehyde)
• 1261869-07-1(2-Chloro-3,4-difluorobenzaldehyde)