Production Method 1

2252-50-8

84194-30-9

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Tetrahydrofuran
1.2 Reagents: Ethyl chloroformate ,  Sodium borohydride ;  10 min, -30 °C; 5 min, -30 °C
1.3 Solvents: Water ;  20 min, rt
1.4 Reagents: Dimethyl sulfoxide ,  Oxalyl chloride Solvents: Dichloromethane ;  20 min, -78 °C
1.5 Solvents: Dichloromethane ;  1 h, -78 °C → -40 °C
1.6 Reagents: Triethylamine

Reference

Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors

Ichikawa, Masanori; Yokomizo, Aki; Itoh, Masao; Usui, Hiroyuki; Shimizu, Hironari; et al, Bioorganic & Medicinal Chemistry, 2011, 19(6), 1930-1949

2-Chloro-5-Fluorobenzaldehyde Raw materials

• 2-Chloro-5-fluorobenzoic acid

2-Chloro-5-Fluorobenzaldehyde Preparation Products

• 2-Chloro-5-Fluorobenzaldehyde (84194-30-9)

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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoyl derivatives
• Solvents and Organic Chemicals Organic Compounds Aldehyde/Ketone

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