- Antipoxvirus Activity Evaluation of Optimized Corroles Based on Development of Autofluorescent ANCHOR Myxoma VirusKappler-Gratias, Sandrine; Bucher, Leo; Top, Sokunthea; Quentin-Froignant, Charlotte; Desbois, Nicolas ; et al, ACS Infectious Diseases, 2021, 7(8), 2370-2382
Cas no 96516-29-9 (2-Fluoro-3-nitrobenzaldehyde)
2-Fluoro-3-nitrobenzaldehyde is a fluorinated nitroaromatic aldehyde with the molecular formula C?H?FNO?. This compound serves as a versatile intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and specialty chemicals. The presence of both fluoro and nitro substituents on the benzaldehyde scaffold enhances its reactivity, enabling selective functionalization at specific positions. Its electron-withdrawing groups facilitate nucleophilic aromatic substitution (SNAr) reactions, making it valuable for constructing complex heterocyclic frameworks. The compound exhibits high purity and stability under standard storage conditions, ensuring reliable performance in synthetic applications. Its well-defined structure and consistent quality make it a preferred choice for research and industrial-scale synthesis.
2-Fluoro-3-nitrobenzaldehyde structure
Product Name:2-Fluoro-3-nitrobenzaldehyde
CAS No:96516-29-9
MF:C7H4FNO3
MW:169.109965324402
MDL:MFCD08669885
CID:838714
PubChem ID:10487325
Update Time:2025-06-07
2-Fluoro-3-nitrobenzaldehyde Chemical and Physical Properties
Names and Identifiers
-
- 2-Fluoro-3-nitrobenzaldehyde
- Benzaldehyde, 2-fluoro-3-nitro-
- 2-fluoro-3-nitro-benzaldehyde
- WLDHPJSICUOHTH-UHFFFAOYSA-N
- AB46095
- SY025595
- ST2409978
- W9810
- AM20050213
- 2-Fluoro-3-nitrobenzaldehyde (ACI)
- Z1198180704
- DB-080428
- MFCD08669885
- DS-0441
- AKOS006290001
- DTXSID90440658
- 96516-29-9
- CS-W003540
- SCHEMBL698799
- J-509378
- EN300-211255
-
- MDL: MFCD08669885
- Inchi: 1S/C7H4FNO3/c8-7-5(4-10)2-1-3-6(7)9(11)12/h1-4H
- InChI Key: WLDHPJSICUOHTH-UHFFFAOYSA-N
- SMILES: O=CC1C(F)=C([N+](=O)[O-])C=CC=1
Computed Properties
- Exact Mass: 169.01800
- Monoisotopic Mass: 169.01752115g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 12
- Rotatable Bond Count: 1
- Complexity: 192
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 62.9
- XLogP3: 1.3
Experimental Properties
- Density: 1.443
- Boiling Point: 279 oC
- Flash Point: 122 oC
- PSA: 62.89000
- LogP: 2.06960
2-Fluoro-3-nitrobenzaldehyde Security Information
- Signal Word:Warning
- Hazard Statement: H302
- Warning Statement: P280-P305+P351+P338
- Storage Condition:Inert atmosphere,2-8°C
2-Fluoro-3-nitrobenzaldehyde Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Chemenu | CM128435-1g |
2-fluoro-3-nitrobenzaldehyde |
96516-29-9 | 95+% | 1g |
$279 | 2021-06-17 | |
| Chemenu | CM128435-5g |
2-fluoro-3-nitrobenzaldehyde |
96516-29-9 | 95+% | 5g |
$779 | 2021-06-17 | |
| Chemenu | CM128435-250mg |
2-fluoro-3-nitrobenzaldehyde |
96516-29-9 | 95+% | 250mg |
$118 | 2022-06-09 | |
| Chemenu | CM128435-1g |
2-fluoro-3-nitrobenzaldehyde |
96516-29-9 | 95+% | 1g |
$285 | 2022-06-09 | |
| Chemenu | CM128435-5g |
2-fluoro-3-nitrobenzaldehyde |
96516-29-9 | 95+% | 5g |
$641 | 2022-06-09 | |
| Fluorochem | 076459-250mg |
2-Fluoro-3-nitrobenzaldehyde |
96516-29-9 | 95.0% | 250mg |
£73.00 | 2023-03-31 | |
| Fluorochem | 076459-1g |
2-Fluoro-3-nitrobenzaldehyde |
96516-29-9 | 95.0% | 1g |
£179.00 | 2023-03-31 | |
| Fluorochem | 076459-5g |
2-Fluoro-3-nitrobenzaldehyde |
96516-29-9 | 95.0% | 5g |
£527.00 | 2023-03-31 | |
| Apollo Scientific | PC501176-250mg |
2-Fluoro-3-nitrobenzaldehyde |
96516-29-9 | 250mg |
£25.00 | 2025-02-21 | ||
| Apollo Scientific | PC501176-1g |
2-Fluoro-3-nitrobenzaldehyde |
96516-29-9 | 1g |
£11.00 | 2023-09-02 |
2-Fluoro-3-nitrobenzaldehyde Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Manganese oxide (MnO2) Solvents: Ethyl acetate ; 2.5 h, reflux
Reference
Production Method 2
Reaction Conditions
1.1 Catalysts: Tempo , Cuprous chloride Solvents: Dimethyl sulfoxide
Reference
- Development and pilot scale implementation of safe aerobic Cu/TEMPO oxidation in a batch reactorLemaitre, Sylvain; Romain, Anne-Lise; Bariere, Francois; Craquelin, Anthony; Copin, Chloe; et al, Green Chemistry, 2023, 25(14), 5698-5711
Production Method 3
Reaction Conditions
Reference
- 1,4-Dihydropyridine-3,5-dicarboxylic acid diester derivatives, Japan, , ,
Production Method 4
Reaction Conditions
Reference
- 1,4-Dihydropyridine derivatives, and their pharmaceutical use, European Patent Organization, , ,
Production Method 5
Reaction Conditions
1.1 Reagents: Potassium fluoride
Reference
- Synthesis and antihypertensive activity of 1,4-dihydropyridine derivatives with a 4-(disubstituted phenyl) ring and an aminoalkyl ester group: highly potent and long-lasting calcium antagonistsKanno, Hideo; Yamaguchi, Hisao; Okamiya, Yoshiaki; Sunakawa, Kiyotaka; Takeshita, Toru; et al, Chemical & Pharmaceutical Bulletin, 1992, 40(8), 2049-54
Production Method 6
Reaction Conditions
1.1 Reagents: Potassium fluoride Solvents: Dimethylformamide ; 5 h, 150 °C
Reference
- Preparation of the condensed bi-heterocycles as inhibiting agents for bruton's tyrosine kinase, World Intellectual Property Organization, , ,
Production Method 7
Reaction Conditions
1.1 Reagents: Potassium fluoride Solvents: Dimethylformamide ; rt → 150 °C; 5 h, 150 °C
Reference
- Preparation of triazinamine derivatives as inhibiting agents for Bruton's tyrosine kinase, World Intellectual Property Organization, , ,
Production Method 8
Reaction Conditions
Reference
- Nitration of Strongly Deactivated Aromatics with Superacidic Mixed Nitric-Triflatoboric Acid (HNO3/2CF3SO3H-B(O3SCF3)3)Olah, George A.; Orlinkov, Alexander; Oxyzoglou, Alexandros B.; Prakash, G. K. Surya, Journal of Organic Chemistry, 1995, 60(22), 7348-50
Production Method 9
Production Method 10
2-Fluoro-3-nitrobenzaldehyde Raw materials
- 2-Fluoro-3-nitrotoluene
- 2-Chloro-3-nitrobenzaldehyde
- 2-Fluoro-3-nitrobenzyl Alcohol
- 2-Fluoro-3-nitrobenzoic acid
2-Fluoro-3-nitrobenzaldehyde Preparation Products
2-Fluoro-3-nitrobenzaldehyde Related Literature
-
Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
-
Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551
-
H. V. Jain,D. Verthelyi,S. L. Beaucage RSC Adv., 2017,7, 42519-42528
-
Yaqing Liu,Jiangtao Ren,Jing Li,Jiyang Liu,Erkang Wang Chem. Commun., 2012,48, 802-804
-
Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
96516-29-9 (2-Fluoro-3-nitrobenzaldehyde) Related Products
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- 1260825-63-5(2,6-difluoro-4-nitrobenzaldehyde)
- 160538-51-2(3-fluoro-4-nitro-benzaldehyde)
- 1160474-72-5(2,5-Difluoro-4-nitrobenzenecarbaldehyde)
- 873697-78-0(1-(2-Fluoro-3-nitrophenyl)ethanone)
- 42564-51-2(4-Fluoro-3-nitrobenzaldehyde)
- 157701-72-9(2-Fluoro-4-nitrobenzaldehyde)
- 320-74-1(2-Fluoro-1,5-dimethyl-3-nitrobenzene)
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