Production Method 1

317-46-4

946126-95-0

Reaction Conditions

1.1 Reagents: (T-4)-Trihydro(tetrahydrofuran)boron Solvents: Tetrahydrofuran ;  1 h, 0 °C; 14 h, heated; 0 °C
1.2 Reagents: Methanol

Reference

Antipoxvirus Activity Evaluation of Optimized Corroles Based on Development of Autofluorescent ANCHOR Myxoma Virus

Kappler-Gratias, Sandrine; Bucher, Leo; Top, Sokunthea; Quentin-Froignant, Charlotte; Desbois, Nicolas ; et al, ACS Infectious Diseases, 2021, 7(8), 2370-2382

Production Method 2

317-46-4

946126-95-0

Reaction Conditions

1.1 Reagents: 4-Methylmorpholine ,  Ethyl chloroformate Solvents: Tetrahydrofuran ;  30 min, 0 °C
1.2 Reagents: Sodium borohydride ;  2 h, rt
1.3 Reagents: Ammonium chloride Solvents: Water ;  rt

Reference

Preparation of heterocycle carboxamide derivatives useful as SIRT2 inhibitors

, United States, , ,

Production Method 3

946126-94-9

946126-95-0

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride Solvents: Toluene ;  -78 °C; 30 min, -78 °C; 30 min, 0 °C; 0 °C → -78 °C
1.2 Reagents: Methanol ,  Potassium sodium tartrate Solvents: Ethyl acetate ,  Water ;  1 h, rt

Reference

Preparation of 2-oxo-2H-benzopyran derivatives and benzo[e][1,3]oxazine-2,4-dione derivatives as P27 protein inducers

, World Intellectual Property Organization, , ,

Production Method 4

317-46-4

946126-95-0

Reaction Conditions

1.1 Reagents: Borane Solvents: Tetrahydrofuran ;  0 °C; 3 d
1.2 Reagents: Methanol

Reference

Preparation of N,N'-diphenylpyrimidinediamine derivatives for use as antiproliferative agents

, World Intellectual Property Organization, , ,

Production Method 5

317-46-4

946126-95-0

Reaction Conditions

1.1 Reagents: Iodine ,  Sodium borohydride Solvents: Tetrahydrofuran ;  0 - 5 °C; 2 h, 0 - 5 °C
1.2 Reagents: Hydrochloric acid Solvents: Water

Reference

Process for preparation of Omecamtiv Mecarbil dihydrochloride

, World Intellectual Property Organization, , ,

Production Method 6

946126-95-0

Reaction Conditions

Reference

Salt of omecamtiv mecarbil and process for preparing salt

, United States, , ,

Production Method 7

946126-95-0

Reaction Conditions

Reference

Preparation of coumarin derivatives as antitumor agents

, World Intellectual Property Organization, , ,

2-Fluoro-3-nitrobenzyl Alcohol Raw materials

• 2-Fluoro-3-nitrobenzoic acid
• Methyl 2-Fluoro-3-nitrobenzoate

2-Fluoro-3-nitrobenzyl Alcohol Preparation Products

• 2-Fluoro-3-nitrobenzyl Alcohol (946126-95-0)

• 1. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 2. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 3. An alumina stabilized graphene oxide wrapped SnO2 hollow sphere LIB anode with improved lithium storage?
  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789
• 4. An atom-economical protocol for direct conversion of Baylis–Hillman alcohols to β-chloro aldehydes in water?
  Raktani Bikshapathi,Sai Prathima Parvathaneni,Vaidya Jayathirtha Rao Green Chem., 2017,19, 4446-4450
• 5. An artificial photosynthesis system comprising a covalent triazine framework as an electron relay facilitator for photochemical carbon dioxide reduction?
  Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200

• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

Professional Introduction to Compound with CAS No. 946126-95-0 and Product Name: 2-Fluoro-3-nitrobenzyl Alcohol

The compound identified by the CAS number 946126-95-0 and the product name 2-Fluoro-3-nitrobenzyl Alcohol represents a significant molecule in the realm of chemical and pharmaceutical research. This compound, characterized by its unique structural and electronic properties, has garnered attention due to its potential applications in various biochemical pathways and drug development strategies.

At the core of understanding this compound lies its molecular structure, which consists of a benzyl alcohol moiety substituted with both a fluorine atom at the 2-position and a nitro group at the 3-position. The presence of these functional groups imparts distinct reactivity and interaction capabilities, making it a versatile intermediate in synthetic organic chemistry. The fluoro group, in particular, is well-known for its ability to modulate metabolic stability and binding affinity in drug molecules, while the nitro group introduces a site for further functionalization through reduction or diazotization reactions.

In recent years, the pharmaceutical industry has witnessed a surge in the exploration of fluorinated aromatic compounds due to their enhanced bioavailability and improved pharmacokinetic profiles. The 2-Fluoro-3-nitrobenzyl Alcohol molecule aligns with this trend, offering a scaffold that can be further modified to develop novel therapeutic agents. For instance, researchers have been investigating its potential as a precursor in the synthesis of kinase inhibitors, where the electron-withdrawing nature of the nitro group enhances binding interactions with target proteins.

Moreover, the 2-Fluoro-3-nitrobenzyl Alcohol has shown promise in the field of medicinal chemistry as a building block for constructing more complex molecules. Its reactivity allows for facile coupling with various pharmacophores, enabling the design of molecules with tailored biological activities. This flexibility is particularly valuable in hit-to-lead optimization campaigns, where rapid access to structurally diverse analogs is crucial.

Recent studies have also highlighted the compound's utility in biochemical assays. The fluoro substituent can serve as a handle for positron emission tomography (PET) imaging probes, facilitating non-invasive visualization of biological processes. Concurrently, the nitro group can be exploited for redox-sensitive applications, allowing researchers to track oxidative stress or enzymatic activity in cellular environments. These applications underscore the compound's multifaceted nature and its potential impact across multiple disciplines.

The synthesis of 2-Fluoro-3-nitrobenzyl Alcohol presents an interesting challenge due to the need for precise functional group placement. Traditional synthetic routes often involve multi-step sequences that require careful control over reaction conditions to avoid unwanted side products. Advances in catalytic methods have recently enabled more efficient pathways, reducing both reaction times and waste generation. Such improvements are critical for sustainable pharmaceutical manufacturing and align with global efforts toward green chemistry principles.

In conclusion, the compound with CAS No. 946126-95-0 and product name 2-Fluoro-3-nitrobenzyl Alcohol represents a compelling example of how structural modifications can yield molecules with broad utility in pharmaceutical research. Its unique combination of functional groups makes it an invaluable tool for synthetic chemists and medicinal biologists alike. As research continues to uncover new applications for this compound, its significance in advancing drug discovery is likely to grow further.

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