Production Method 1

317-46-4

946126-94-9

Reaction Conditions

1.1 Reagents: Oxalyl chloride Catalysts: Dimethylformamide Solvents: Dichloromethane ;  rt
1.2 5 min, rt

Reference

From off-to on-target: New BRAF-inhibitor-template-derived compounds selectively targeting mitogen activated protein kinase kinase 4 (MKK4)

Kloevekorn, Philip; Pfaffenrot, Bent; Juchum, Michael; Selig, Roland ; Albrecht, Wolfgang ; et al, European Journal of Medicinal Chemistry, 2021, 210,

Production Method 2

317-46-4

946126-94-9

Reaction Conditions

1.1 Reagents: Oxalyl chloride Catalysts: Dimethylformamide Solvents: Dichloromethane ;  rt
1.2 rt

Reference

Preparation of 1H-pyrrolo[2,3-b]pyridines as selective MKK4 kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death

, World Intellectual Property Organization, , ,

Production Method 3

317-46-4

946126-94-9

Reaction Conditions

1.1 Catalysts: Sulfuric acid Solvents: Methanol ,  Water ;  overnight, 70 °C; 70 °C → rt

Reference

Preparation of benzenesulfonamidethiazole derivatives and analogs for use as B-Raf protein kinase inhibitors

, World Intellectual Property Organization, , ,

Production Method 4

53553-14-3

946126-94-9

Reaction Conditions

1.1 Reagents: Cesium fluoride Solvents: Dimethyl sulfoxide ;  40 min, 140 °C

Reference

Preparation of 2-oxo-2H-benzopyran derivatives and benzo[e][1,3]oxazine-2,4-dione derivatives as P27 protein inducers

, World Intellectual Property Organization, , ,

Production Method 5

317-46-4

946126-94-9

Reaction Conditions

1.1 Catalysts: Sulfuric acid Solvents: Methanol ;  16 h, 50 °C

Reference

Preparation of oxazoles and thiazoles as protein kinase inhibitors

, World Intellectual Property Organization, , ,

Production Method 6

53553-14-3

946126-94-9

Reaction Conditions

1.1 Reagents: Cesium fluoride Solvents: Dimethylformamide ;  1 h, 140 °C

Reference

Fluorinated aniline derivatives and their preparation

, Japan, , ,

Production Method 7

34128-16-0

946126-94-9

Reaction Conditions

1.1 Reagents: Potassium fluoride Solvents: Dimethylformamide ;  rt → 145 °C; 2 h, 110 - 140 °C; 140 °C → 50 °C
1.2 15 min, 50 °C
1.3 Solvents: Water ;  10 min, rt

Reference

Process for the preparation of substituted benzoates

, India, , ,

Production Method 8

946126-94-9

Reaction Conditions

Reference

Preparation of coumarin derivatives as antitumor agents

, World Intellectual Property Organization, , ,

Production Method 9

317-46-4

946126-94-9

Reaction Conditions

1.1 Catalysts: Sulfuric acid Solvents: Methanol ,  Water ;  overnight, 70 °C; 70 °C → rt

Reference

Preparation of benzene sulfonamide thiazole and oxazole compounds

, World Intellectual Property Organization, , ,

Production Method 10

317-46-4

946126-94-9

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  rt
1.2 1 h, rt
1.3 Reagents: Water

Reference

Preparation of thiazole kinase inhibitors

, China, , ,

Production Method 11

317-46-4

946126-94-9

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Methanol ;  2 h, 60 °C

Reference

Crystallographic Realization of the Mathematically Predicted Densest All-Pentagon Packing Lattice by C5-Symmetric "Sticky" Fluoropentamers

Ren, Changliang; Zhou, Feng; Qin, Bo; Ye, Ruijuan; Shen, Sheng; et al, Angewandte Chemie, 2011, 50(45), 10612-10615

Production Method 12

317-46-4

946126-94-9

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Methanol ,  Water ;  2 h, 60 °C

Reference

Planar Macrocyclic Fluoropentamers as Supramolecular Organogelators

Ren, Changliang; Xu, Shengyu; Xu, Jun; Chen, Hongyu; Zeng, Huaqiang, Organic Letters, 2011, 13(15), 3840-3843

Production Method 13

1493-27-2

946126-94-9

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide ,  Boric acid (H3BO3) Solvents: Tetrahydrofuran ;  cooled; 1 h, heated
1.2 -5 °C; 3.5 h, -5 °C → rt; rt → -5 °C
1.3 Reagents: Ammonium chloride Solvents: Water ;  -5 °C

Reference

Green method for synthesis of key intermediates of tyrosine kinase inhibitor

, China, , ,

Production Method 14

53553-14-3

946126-94-9

Reaction Conditions

1.1 Reagents: Cesium fluoride Solvents: Dimethylformamide ;  1 h, 140 °C

Reference

Method for producing N-phenyl-3-(benzamido or 3-pyridylcarbonylamino)benzamide derivatives

, World Intellectual Property Organization, , ,

Production Method 15

946126-94-9

Reaction Conditions

Reference

Preparation of thiazole sulfonamides and oxazole sulfonamides as antitumor agents

, Costa Rica, , ,

Methyl 2-Fluoro-3-nitrobenzoate Raw materials

• 2-Chloro-3-nitro-benzoyl Chloride
• 1-Fluoro-2-nitrobenzene
• 2-Fluoro-3-nitrobenzoic acid
• Methyl 2-chloro-3-nitrobenzoate

Methyl 2-Fluoro-3-nitrobenzoate Preparation Products

• Methyl 2-Fluoro-3-nitrobenzoate (946126-94-9)

• 1. Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides?
  Chen-Yu Chien,Sheng-Sheng Yu Chem. Commun., 2020,56, 11949-11952
• 2. Excited-state proton-coupled electron transfer within ion pairs?
  Gerald J. Meyer,Leif Hammarstr?m Chem. Sci., 2020,11, 3460-3473
• 3. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 4. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 5. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Nitrobenzoic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Nitrobenzoic acids and derivatives

• 1154279-29-4(Ethyl 2,5-difluoro-3-nitrobenzoate)
• 1214379-18-6(Ethyl 2-fluoro-3-nitrobenzoate)
• 1154278-08-6(Methyl 2,5-difluoro-3-nitrobenzoate)
• 918321-24-1(Methyl 2,3,4-trifluoro-5-nitrobenzoate)
• 2965-22-2(Methyl 2-fluoro-5-nitrobenzoate)
• 1214367-00-6(Ethyl 2,5-difluoro-4-nitrobenzoate)
• 179011-37-1(ethyl 2,4-difluoro-5-nitro-benzoate)
• 125568-71-0(Methyl 2,4-difluoro-5-nitrobenzoate)
• 924868-81-5(Methyl 2,5-difluoro-4-nitrobenzoate)
• 84832-01-9(Methyl 2,6-difluoro-3-nitrobenzoate)