Cas no 964-21-6 (O6-Methyl-2’-deoxyguanosine)

O6-Methyl-2’-deoxyguanosine structure

Product Name:O6-Methyl-2’-deoxyguanosine

CAS No:964-21-6

MF:C₁₁H₁₅N₅O₄

MW:281.267901659012

CID:808030

PubChem ID:73317

Update Time:2024-12-09

O6-Methyl-2’-deoxyguanosine Chemical and Physical Properties

Names and Identifiers

- Guanosine,2'-deoxy-6-O-methyl-
- O6-METHYL-2’-DEOXYGUANOSINE
- O6-METHYL-2'-DEOXYGUANOSINE
- 2-Amino-6-methoxy-2'-deoxy-6-deaminoadenosine
- 6-O-METHYL-2'-DEOXYGUANOSINE
- O(6)-methyl-2'-deoxyguanosine
- O6-methyl-2'-deoxy-guanosine
- O6-methyldeoxyguanosine
- 2′-Deoxy-6-O-methylguanosine (ACI)
- 9H-Purine, 2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxy- (8CI)
- D
- 9H-Purine, 2-amino-9-(2-deoxy-β-D-ribofuranosyl)-6-methoxy- (7CI)
- 2-Amino-6-methoxy-9-(2-deoxy-β-D-erythro-pentofuranosyl)purine
- 2′-Deoxy-6-methylguanosine
- 6-O-Methyl-2′-deoxyguanosine
- 6-O-Methyldeoxyguanosine
- O6-Methyl-2′-deoxyguanosine
- O6-Methyl-dG
- 2'-Deoxy-N2-methyl-D-guanosine
- DTXSID60242222
- DA-70322
- 964-21-6
- G76585
- 2-Amino-9-(2-deoxy-ss-D-erythro-pentofuranosyl)-6-methoxy-9H-purine; 2-Amino-9-(2-deoxy-ss-D-ribofuranosyl)-6-methoxy-9H-purine; 2'-Deoxy-6-O-methylguanosine; 2'-Deoxy-6-methylguanosine; 2-Amino-6-methoxy-9-(2-deoxy-ss-D-erythro-pentofuranosyl)purine;
- BIDD:GT0852
- Epitope ID:146099
- (2R,3S,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol
- Guanosine, 2'-deoxy-6-O-methyl-
- O6-methyl-2 -deoxyguanosine
- BCKDNMPYCIOBTA-RRKCRQDMSA-N
- DTXCID60164713
- C05031
- 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-methoxy-9H-purin-2-amine
- SCHEMBL657819
- J03
- Q27103189
- (2~{R},3~{S},5~{R})-5-(2-azanyl-6-methoxy-purin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
- 2-amino-6-methoxy-9-(2-deoxy-Beta-D-erythro-pentofuranosyl)purine
- (2R,3S,5R)-5-(2-amino-6-methoxy-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol
- (2R,3S,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
- 2'-Deoxy-O(6)-methylguanosine
- (2R,3S,5R)-5-(2-amino-6-methoxypurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
- CHEBI:27549
- O6 -methyldeoxyguanosine
- O(6)-Methyldeoxyguanosine
- O6-Methyl-2-deoxyguanosine
- O6-Methyl-2’-deoxyguanosine
- Inchi： 1S/C11H15N5O4/c1-19-10-8-9(14-11(12)15-10)16(4-13-8)7-2-5(18)6(3-17)20-7/h4-7,17-18H,2-3H2,1H3,(H2,12,14,15)/t5-,6+,7+/m0/s1
- InChI Key： BCKDNMPYCIOBTA-RRKCRQDMSA-N
- SMILES： O(C1N=C(N)N=C2N([C@H]3C[C@H](O)[C@@H](CO)O3)C=NC=12)C

Computed Properties

Exact Mass: 281.11200
Monoisotopic Mass: 281.11240398g/mol
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 8
Heavy Atom Count: 20
Rotatable Bond Count: 3
Complexity: 349
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 3
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
XLogP3: 0.1
Topological Polar Surface Area: 129?2

Experimental Properties

PSA: 128.54000
LogP: -0.36100

O6-Methyl-2’-deoxyguanosine Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
TRC	M293040-5mg	O6-Methyl-2’-deoxyguanosine	964-21-6		5mg	$ 238.00	2023-09-07
TRC	M293040-10mg	O6-Methyl-2’-deoxyguanosine	964-21-6		10mg	$ 391.00	2023-09-07
TRC	M293040-25mg	O6-Methyl-2’-deoxyguanosine	964-21-6		25mg	$ 799.00	2023-09-07
SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd.	D918016-5mg	2'-Deoxy-6-O-methyl-guanosine	964-21-6	90%	5mg	￥2,160.00	2022-01-13
A2B Chem LLC	AO82178-50mg	O6-Methyl-deoxyguanosine	964-21-6	99%	50mg	$1285.00	2024-07-18
A2B Chem LLC	AO82178-100mg	O6-Methyl-deoxyguanosine	964-21-6	98%	100mg	$1595.00	2025-05-29
1PlusChem	1P00VS9U-10mg	O6-Methyl-deoxyguanosine	964-21-6	98	10mg	$250.00	2025-03-01
1PlusChem	1P00VS9U-25mg	O6-Methyl-deoxyguanosine	964-21-6	98	25mg	$439.00	2025-03-01
1PlusChem	1P00VS9U-50mg	O6-Methyl-deoxyguanosine	964-21-6		50mg	$1467.00	2024-04-19
1PlusChem	1P00VS9U-100mg	O6-Methyl-deoxyguanosine	964-21-6	98%	100mg	$1522.00	2025-03-01

O6-Methyl-2’-deoxyguanosine Production Method

Production Method 1

705255-09-0

964-21-6

Reaction Conditions

1.1 Reagents: Dowex 1X2 Solvents: Methanol ; 27 h, rt

Reference

: Functionalization of Guanosine and 2'-Deoxyguanosine at C6: A Modified Appel Process and SNAr Displacement of Imidazole

Janeba, Zlatko; Lin, Xiaoyu; Robins, Morris J., Nucleosides, 2004, 23, 137-147

Production Method 2

961-07-9

964-21-6

Reaction Conditions

1.1 Reagents: Trifluoroacetic anhydride Solvents: Pyridine
1.2 Reagents: Sodium methoxide Solvents: Methanol
1.3 Reagents: Pyridine , Hydrochloric acid

Reference

: Synthesis of 6-substituted 2'-deoxyguanosine derivatives using trifluoroacetic anhydride in pyridine

Fathi, Reza; Goswami, Bhaswati; Kung, Pei Pei; Gaffney, Barbara L.; Jones, Roger A., Tetrahedron Letters, 1990, 31(3), 319-22

Production Method 3

961-07-9

21561-99-9

964-21-6

Reaction Conditions

1.1 Solvents: Methanol

Reference

: N-Nitroso compounds. VII. Mechanism of nucleoside alkylation by alkylnitrosourea - reaction of 2'-deoxyguanosine with N-nitroso-N-methyl-N'-phenylurea in Methanol

Yoshida, Kitaro; Yano, Kazuyuki; Yano, Yumihiko, Nippon Kagaku Kaishi, 1996, (1), 100-3

Production Method 4

128790-76-1

964-21-6

Reaction Conditions

Reference

: Product class 17: purines

Seela, F.; Ramzaeva, N.; Rosemeyer, H., Science of Synthesis, 2004, 16, 945-1108

Production Method 5

31081-04-6

961-07-9

964-21-6

Reaction Conditions

Reference

: Detection of O6-Carboxymethyl-2'-deoxyguanosine in DNA Following Reaction of Nitric Oxide with Glycine and in Human Blood DNA Using a Quantitative Immunoslot Blot Assay

Cupid, Belinda C.; Zeng, Zuotao; Singh, Rajinder; Shuker, David E. G., Chemical Research in Toxicology, 2004, 17(3), 294-300

Production Method 6

964-21-6

Reaction Conditions

Reference

: Nucleotide prodrugs

, World Intellectual Property Organization, , ,

Production Method 7

964-21-6

Reaction Conditions

Reference

: Synthesis and Characterization of DNA Containing O6-Carboxymethylguanine

Xu, Y.-Z., Tetrahedron, 2000, 56(33), 6075-6081

Production Method 8

964-21-6

Reaction Conditions

Reference

: The mechanism of decomposition of N-methyl-N-nitrosourea (MNU) in water and a study of its reactions with 2'-deoxyguanosine, 2'-deoxyguanosine 5'-monophosphate and d(GTGCAC)

Golding, Bernard T.; Bleasdale, Christine; McGinnis, Joseph; Mueller, Susanna; Rees, Hue Thu; et al, Tetrahedron, 1997, 53(11), 4063-4082

Production Method 9

964-21-6

Reaction Conditions

Reference

: Synthesis of O-6-alkylated deoxyguanosine nucleosides

Gaffney B. L.; Jones, R. A., Tetrahedron Letters, 1982, 23(22), 2253-6

Production Method 10

128790-76-1

964-21-6

Reaction Conditions

1.1 Reagents: Triethylamine , 1,8-Diazabicyclo[5.4.0]undec-7-ene Solvents: Methanol

Reference

: 6-O-Substituted guanosine derivatives prepared by acylation and substitution reactions

, United States, , ,

Production Method 11

961-07-9

964-21-6

Reaction Conditions

1.1 Solvents: Diethyl ether , Methanol ; 4 h, -20 °C

Reference

: Preparation of nucleotide prodrugs and their use treating a mitochondrial DNA depletion syndrome

, World Intellectual Property Organization, , ,

Production Method 12

20535-83-5

14215-97-5

964-21-6

Reaction Conditions

1.1 Reagents: N,O-Bis(trimethylsilyl)acetamide Catalysts: Trimethylsilyl triflate Solvents: Acetonitrile ; 5 min, 130 °C
1.2 Reagents: Triethanolamine Solvents: Acetonitrile , Water ; 30 min, rt
1.3 Reagents: Silica Solvents: Methanol , Dichloromethane ; rt
1.4 Reagents: Ammonia Solvents: Methanol ; 16 h, 50 °C
1.5 Reagents: Silica Solvents: Methanol , Dichloromethane ; rt

Reference

: High-Throughput Five Minute Microwave Accelerated Glycosylation Approach to the Synthesis of Nucleoside Libraries

Bookser, Brett C.; Raffaele, Nicholas B., Journal of Organic Chemistry, 2007, 72(1), 173-179

Production Method 13

128790-76-1

964-21-6

Reaction Conditions

1.1 Reagents: Sodium methoxide

Reference

: 6-O-(Pentafluorophenyl)-2'-deoxyguanosine: a versatile synthon for nucleoside and oligonucleotide synthesis

Gao, Hetian; Fathi, Reza; Gaffney, Barbara L.; Goswami, Bhaswati; Kung, Pei Pei; et al, Journal of Organic Chemistry, 1992, 57(25), 6954-9

Production Method 14

964-21-6

Reaction Conditions

Reference

: N7-DNA: synthesis and base pairing of oligonucleotides containing N7-(2-deoxy-β-D-erythro-pentofuranosyl)guanine (N7Gd)

Seela, Frank; Leonard, Peter, Helvetica Chimica Acta, 1996, 79(2), 477-87

Production Method 15

964-21-6

Reaction Conditions

Reference

: Synthesis of Oligodeoxyribonucleotides Containing Analogs of O6-Methylguanine and Reaction with O6-Alkylguanine-DNA Alkyltransferase

Spratt, Thomas E.; Campbell, Colin R., Biochemistry, 1994, 33(37), 11364-71

Production Method 16

964-21-6

Reaction Conditions

Reference

: Deacylation of 2-N-isobutyryl- and 2-N-isobutyryl-6-O-methyl-2'-deoxyguanosine in the condensed and gas phase. A kinetic investigation

Liguori, Angelo; Napoli, Anna; Siciliano, Carlo; Sindona, Giovanni, Journal of the Chemical Society, 1994, (8), 1833-8

Production Method 17

964-21-6

Reaction Conditions

Reference

: Solid-phase synthesis of oligodeoxynucleotides containing 6-O-alkylguanosines

Roelen, H. C. P. F.; Brugghe, H. F.; Van den Elst, H.; Klein, J. C.; Van der Marel, G. A.; et al, Recueil des Travaux Chimiques des Pays-Bas, 1992, 111(5), 227-34

Production Method 18

964-21-6

Reaction Conditions

Reference

: Preparation of O6-methyldeoxyguanosine monophosphate

Wang, Jujun, Huaxue Shiji, 1990, 12(2), 112-13

Production Method 19

964-21-6

Reaction Conditions

Reference

: A one step synthesis of O6-methyl-2'-deoxyguanosine

Bernadou, Jean; Blandin, Michel; Meunier, Bernard, Nucleosides & Nucleotides, 1983, 2(5), 459-64

Production Method 20

964-21-6

Reaction Conditions

Reference

: Synthesis of benzyl and benzyloxycarbonyl base-blocked 2'-deoxyribonucleosides

Watkins, Bruce E.; Rapoport, Henry, Journal of Organic Chemistry, 1982, 47(23), 4471-7

O6-Methyl-2’-deoxyguanosine Raw materials

O6-Methyl-2’-deoxyguanosine Preparation Products

O6-Methyl-2’-deoxyguanosine (964-21-6)

O6-Methyl-2’-deoxyguanosine Suppliers

Amadis Chemical Company Limited

Gold Member

Audited Supplier

(CAS:964-21-6)(2R,3S,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol

Order Number:A945430

Stock Status:in Stock

Quantity:100mg

Purity:99%

Pricing Information Last Updated:Friday, 30 August 2024 15:51

Price ($):1306.0

Email:[email protected]

Product Official Link

NewCan Biotech Limited

Gold Member

Audited Supplier

(CAS:964-21-6)2'-Deoxy-6-O-methyl-guanosine

Order Number:NC14392

Stock Status:

Quantity:10g

Purity:97%

Pricing Information Last Updated:Friday, 18 July 2025 16:00

Price ($):Price inquiry

Email:[email protected]

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Related Categories

Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Purine nucleosides Purine 2'-deoxyribonucleosides

964-21-6 (O6-Methyl-2’-deoxyguanosine) Related Products

Recommended suppliers

Amadis Chemical Company Limited

(CAS:964-21-6)(2R,3S,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol

Purity:99%

Quantity:100mg

Price ($):1306.0

NewCan Biotech Limited

(CAS:964-21-6)2'-Deoxy-6-O-methyl-guanosine

Purity:97%

Quantity:10g

Price ($):Inquiry

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Cas no 964-21-6 (O6-Methyl-2’-deoxyguanosine)

O6-Methyl-2’-deoxyguanosine Chemical and Physical Properties

Names and Identifiers

Computed Properties

Experimental Properties

O6-Methyl-2’-deoxyguanosine Pricemore >>

O6-Methyl-2’-deoxyguanosine Production Method

Production Method 1

Production Method 2

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O6-Methyl-2’-deoxyguanosine Raw materials

O6-Methyl-2’-deoxyguanosine Preparation Products

O6-Methyl-2’-deoxyguanosine Suppliers

O6-Methyl-2’-deoxyguanosine Related Literature

Related Categories

964-21-6 (O6-Methyl-2’-deoxyguanosine) Related Products