Cas no 50704-46-6 (O6-Ethyl-2’-deoxyguanosine)
O6-Ethyl-2’-deoxyguanosine Chemical and Physical Properties
Names and Identifiers
-
- Guanosine,2'-deoxy-6-O-ethyl-
- 5-(2-amino-6-ethoxypurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
- O(6)-ethyl-2'-deoxyguanosine
- O6-Ethyl-2’-deoxyguanosine
- O6-Ethyl-2'-deoxyguanosine
- O6-ethyl-2'-deoxy-guanosine
- SCHEMBL7512181
- UNII-UG1B1H0FL4
- 9H-Purin-2-amine, 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-ethoxy-
- 2'-Deoxy-O(6)-ethylguanosine
- NSC-240591
- O6-Ethyl-deoxyguanosine
- 50704-46-6
- UG1B1H0FL4
- AQRYUWBBKDNOHV-XLPZGREQSA-N
- CHEBI:61013
- NSC 240591
- O6 -ethyldeoxyguanosine
- 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-ethoxy-9H-purin-2-amine
- Q27130565
- Guanosine, 2'-deoxy-6-O-ethyl-
- Epitope ID:146098
- O(6)-Ethyldeoxyguanosine
- o6-ethyldeoxyguanosine
- 2'-DEOXY-6-O-ETHYLGUANOSINE
- MFCD00800198
- (2R,3S,5R)-5-(2-amino-6-ethoxy-9H-purin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
- DB-266575
- O6-Ethyl-2'-deoxyguanosine;
-
- Inchi： 1S/C12H17N5O4/c1-2-20-11-9-10(15-12(13)16-11)17(5-14-9)8-3-6(19)7(4-18)21-8/h5-8,18-19H,2-4H2,1H3,(H2,13,15,16)/t6-,7+,8+/m0/s1
- InChI Key： AQRYUWBBKDNOHV-XLPZGREQSA-N
- SMILES： O1[C@H](CO)[C@H](C[C@@H]1N1C=NC2C(=NC(N)=NC1=2)OCC)O
Computed Properties
- Exact Mass: 295.12821
- Monoisotopic Mass: 295.12805404g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 3
- Hydrogen Bond Acceptor Count: 8
- Heavy Atom Count: 21
- Rotatable Bond Count: 4
- Complexity: 363
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 3
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 0.5
- Topological Polar Surface Area: 129?2
Experimental Properties
- PSA: 128.54
- LogP: 0.02910
O6-Ethyl-2’-deoxyguanosine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | E913800-2.5mg |
O6-Ethyl-2’-deoxyguanosine |
50704-46-6 | 2.5mg |
$ 105.00 | 2022-06-05 | ||
| TRC | E913800-10mg |
O6-Ethyl-2’-deoxyguanosine |
50704-46-6 | 10mg |
$ 1378.00 | 2023-09-07 | ||
| TRC | E913800-25mg |
O6-Ethyl-2’-deoxyguanosine |
50704-46-6 | 25mg |
$ 825.00 | 2022-06-05 | ||
| TRC | E913800-1mg |
O6-Ethyl-2’-deoxyguanosine |
50704-46-6 | 1mg |
$ 173.00 | 2023-09-07 | ||
| TRC | E913800-5mg |
O6-Ethyl-2’-deoxyguanosine |
50704-46-6 | 5mg |
$ 775.00 | 2023-09-07 | ||
| SHENG KE LU SI SHENG WU JI SHU | sc-497569-2.5 mg |
O6-Ethyl-2’-deoxyguanosine-d5, |
50704-46-6 | 2.5 mg |
￥2,858.00 | 2023-07-11 | ||
| SHENG KE LU SI SHENG WU JI SHU | sc-497568-1 mg |
O6-Ethyl-2′-deoxyguanosine, |
50704-46-6 | 1mg |
￥2,858.00 | 2023-07-11 | ||
| SHENG KE LU SI SHENG WU JI SHU | sc-497568-1mg |
O6-Ethyl-2′-deoxyguanosine, |
50704-46-6 | 1mg |
￥2858.00 | 2023-09-05 | ||
| SHENG KE LU SI SHENG WU JI SHU | sc-497569-2.5mg |
O6-Ethyl-2’-deoxyguanosine-d5, |
50704-46-6 | 2.5mg |
￥2858.00 | 2023-09-05 | ||
| A2B Chem LLC | AG23831-1mg |
O(6)-ethyl-2'-deoxyguanosine |
50704-46-6 | 1mg |
$289.00 | 2024-04-19 |
O6-Ethyl-2’-deoxyguanosine Suppliers
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O6-Ethyl-2’-deoxyguanosine Related Literature
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J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
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J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
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Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615
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Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168
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Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
Additional information on O6-Ethyl-2’-deoxyguanosine
O6-Ethyl-2'-Deoxyguanosine: A Comprehensive Overview
O6-Ethyl-2'-deoxyguanosine (CAS No. 50704-46-6) is a nucleoside analog that has garnered significant attention in the fields of molecular biology, pharmacology, and cancer research. This compound is a modified form of deoxyguanosine, where an ethyl group is attached to the O6 position of the guanine base. This structural modification imparts unique properties to the molecule, making it a valuable tool in understanding DNA damage and repair mechanisms, as well as in the development of anticancer therapies.
The structural characterization of O6-Ethyl-2'-deoxyguanosine has been extensively studied using advanced analytical techniques such as nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. These studies have revealed that the ethylation at the O6 position significantly alters the electronic environment of the guanine base, potentially affecting its interactions with other biomolecules. Recent research has also highlighted the importance of this modification in modulating the stability and reactivity of DNA strands.
In terms of biological activity, O6-Ethyl-2'-deoxyguanosine has been implicated in various cellular processes, particularly those involving DNA damage and repair. For instance, studies have shown that this compound can interfere with the function of DNA methyltransferases, which are enzymes responsible for adding methyl groups to DNA. This interference can lead to aberrant DNA methylation patterns, which are often associated with cancer development. Recent findings from clinical trials have further underscored the potential of this compound as a chemotherapeutic agent, particularly in combination with other anticancer drugs.
The synthesis of O6-Ethyl-2'-deoxyguanosine has also been optimized in recent years, with researchers developing more efficient and scalable methods for its production. These advancements have made it easier to obtain high-purity samples for use in preclinical and clinical studies. Moreover, the compound's stability under various storage conditions has been thoroughly evaluated, ensuring its reliability as a research tool and potential therapeutic agent.
From a pharmacological perspective, O6-Ethyl-2'-deoxyguanosine exhibits a unique pharmacokinetic profile, which makes it an attractive candidate for targeted drug delivery systems. Studies have shown that the compound can be effectively delivered to specific tissues using nanotechnology-based carriers, enhancing its therapeutic efficacy while minimizing systemic toxicity. This approach has shown promising results in preclinical models of cancer, paving the way for future clinical applications.
In conclusion, O6-Ethyl-2'-deoxyguanosine (CAS No. 50704-46-6) is a versatile compound with significant implications for both basic research and drug development. Its unique chemical properties and biological activities make it an invaluable tool for understanding complex cellular processes and designing novel therapeutic strategies. As research continues to uncover new insights into its mechanisms of action, this compound is poised to play an increasingly important role in advancing our understanding of DNA biology and cancer treatment.
50704-46-6 (O6-Ethyl-2’-deoxyguanosine) Related Products
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