Production Method 1

13365-26-9

96385-50-1

Reaction Conditions

1.1 Reagents: Ammonium hydroxide Solvents: Benzene ,  Water ;  70 h, rt

Reference

Preparation and applications of metallophthalocyanine derivatives

, China, , ,

Production Method 2

603-62-3

96385-50-1

Reaction Conditions

1.1 Solvents: Methanol ;  3 h, -5 - 0 °C

Reference

Synthesis of 3-nitrophthalonitrile

Chen, Zhi-min; Zuo, Xia; Wu, Yi-qun; Chen, Nai-sheng, Hecheng Huaxue, 2004, 12(2), 167-169

Production Method 3

603-62-3

96385-50-1

Reaction Conditions

1.1 Reagents: Ammonium hydroxide Solvents: Water ;  5 h, 45 °C

Reference

Synthesis of 3- or 4-nitrophthalonitrile

, China, , ,

Production Method 4

603-62-3

96385-50-1

Reaction Conditions

1.1 Reagents: Ammonia Solvents: Methanol ;  rt → 0 °C

Reference

Synthesis and characterization of α-tetraalkylphenoxy substituted phthalocyanine transition metal complexes

Li, Bang-yu; Wang, Jun-dong; Yang, Su-ling; Chen, Nai-sheng, Hecheng Huaxue, 2003, 11(2), 138-141

Production Method 5

641-70-3

96385-50-1

Reaction Conditions

1.1 Reagents: Ammonia Solvents: Water ;  0 °C

Reference

Inhibitory properties of 2-substituent-1H-benzimidazole-4-carboxamide derivatives against enteroviruses

Xue, Fei; Luo, Xianjin; Ye, Chenghao; Ye, Weidong; Wang, Yue, Bioorganic & Medicinal Chemistry, 2011, 19(8), 2641-2649

Production Method 6

603-62-3

96385-50-1

Reaction Conditions

1.1 Reagents: Ammonium hydroxide

Reference

Synthesis of subphthalocyanine compound derivatives and their properties

Kim, Jae Hwan; Heo, Jin; Lee, Yun-Yi; Kim, Bo Hyun; Lee, Geun-Dae; et al, Kongop Hwahak, 2009, 20(1), 46-51

Production Method 7

603-62-3

96385-50-1

Reaction Conditions

1.1 Reagents: Ammonium hydroxide

Reference

Kinetics and equilibrium in the ammonolysis of substituted phthalimides

McClelland, Robert A.; Seaman, N. Esther; Duff, James M.; Branston, R. E., Canadian Journal of Chemistry, 1985, 63(1), 121-8

Production Method 8

96385-50-1

Reaction Conditions

Reference

Synthesis of 3-nitrophthalonitrile and tetra-α-substituted phthalocyanines

George, Robert D.; Snow, Aruthur W., Journal of Heterocyclic Chemistry, 1995, 32(2), 495-8

3-Nitrophthalamide Raw materials

• Dimethyl 3-nitrophthalate
• 3-Nitrophthalimide
• 3-Nitrophthalic anhydride

3-Nitrophthalamide Preparation Products

• 3-Nitrophthalamide (96385-50-1)

• 1. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
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Comprehensive Overview of 3-Nitrophthalamide (CAS No. 96385-50-1): Properties, Applications, and Industry Insights

3-Nitrophthalamide (CAS No. 96385-50-1) is a specialized organic compound widely recognized for its role in pharmaceutical intermediates and fine chemical synthesis. With the increasing demand for high-precision chemicals in drug development and material science, this compound has garnered significant attention. Its molecular structure, characterized by a nitro group (-NO₂) attached to a phthalamide backbone, enables unique reactivity patterns, making it valuable for nitration reactions and amide-based derivatization.

Recent trends in green chemistry and sustainable synthesis have spurred interest in optimizing the production of 3-Nitrophthalamide. Researchers are exploring eco-friendly catalysts and solvent-free methodologies to reduce environmental impact while maintaining yield efficiency. This aligns with global initiatives like the UN Sustainable Development Goals (SDGs), particularly Goal 12 (Responsible Consumption and Production).

From an industrial perspective, 3-Nitrophthalamide serves as a precursor for agrochemicals and dye intermediates. Its nitro group facilitates electrophilic substitution reactions, enabling the synthesis of complex aromatic compounds. A frequently asked question in academic forums is: "How does 3-Nitrophthalamide compare to 4-Nitrophthalamide in reactivity?" Studies indicate that the meta-position of the nitro group in 3-Nitrophthalamide offers distinct steric and electronic effects, influencing regioselectivity in subsequent reactions.

Analytical techniques such as HPLC, NMR spectroscopy, and mass spectrometry are critical for quality control of CAS No. 96385-50-1. Purity thresholds exceeding 98% are often required for pharmaceutical-grade applications, underscoring the need for advanced purification methods like recrystallization or column chromatography.

In the context of AI-driven drug discovery, 3-Nitrophthalamide has been flagged in computational databases for its potential bioactivity. Machine learning models predict its utility in designing enzyme inhibitors, though experimental validation remains ongoing. This intersection of computational chemistry and traditional synthesis highlights the compound's evolving relevance.

Storage and handling protocols for 3-Nitrophthalamide emphasize stability under inert atmospheres and protection from moisture. Industry best practices recommend amber glass containers and desiccants to prolong shelf life—a topic frequently searched in chemical storage guidelines.

Looking ahead, innovations in continuous flow chemistry may revolutionize the scalability of 3-Nitrophthalamide production. Pilot studies demonstrate enhanced reaction control and reduced waste generation, addressing both economic and ecological concerns. As regulatory frameworks tighten, compliance with REACH and FDA guidelines will remain pivotal for market access.

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