Cas no 148-01-6 (Dinitolmide)

Dinitolmide (3,5-Dinitro-o-toluamide) is a synthetic antiprotozoal agent primarily used as a coccidiostat in poultry and livestock. Its mechanism of action involves disrupting the energy metabolism of coccidia, effectively inhibiting their growth and replication. Dinitolmide is valued for its targeted activity against Eimeria spp., a common cause of coccidiosis, while exhibiting low toxicity to host animals. It is typically administered via feed and demonstrates stability under standard storage conditions. The compound’s efficacy, combined with its favorable safety profile, makes it a practical choice for prophylactic and therapeutic applications in veterinary medicine. Resistance management remains a consideration in its long-term use.
Dinitolmide structure
Dinitolmide structure
Product Name:Dinitolmide
CAS No:148-01-6
MF:C8H7N3O5
MW:225.158281564713
MDL:MFCD00072065
CID:36565
PubChem ID:3092
Update Time:2025-06-08

Dinitolmide Chemical and Physical Properties

Names and Identifiers

    • 2-Methyl-3,5-dinitrobenzamide
    • Bornylformiat
    • 3,5-Dinitro-o-toluamide
    • DINITOLMIDE
    • 3,5-Dinitro Toluamide
    • D.O.T ZOALENE
    • 2-Methyl-3,5-dinitrobenzamide,3,5-Dinitro-o-toluamide
    • d.o.t.
    • zoamix
    • ZOALENE
    • Zoalere
    • coccidot
    • NITROMID
    • Coccidin
    • Salcostat
    • dinitolmid
    • coccidinea
    • Coccidine A
    • Dinitolmida
    • Benzamide, 2-methyl-3,5-dinitro-
    • Zoalene [ANSI]
    • Dinitolmidum
    • Dinitrotoluamide
    • Dinitolmide [INN:BAN]
    • Dinitro-o-toluamide
    • Methyldinitrobenzamide
    • Caswell No. 932
    • Dinitolmidum [INN-Latin]
    • Dinitolmida [INN-Spanish]
    • o-Toluamide, 3,5-dinitro-
    • AOX68RY4TV
    • EPA Pesticide Chemical Code 037510
    • 3,5-Dini
    • Pharmakon1600-01503036
    • MLS002695903
    • KBio1_000214
    • Dinitolmide (INN)
    • DTXCID4022521
    • NS00021673
    • AC-20062
    • BRN 1990738
    • HY-B1004
    • DINITOLMIDE [MI]
    • SW219233-1
    • Tox21_111374_1
    • C8H7N3O5
    • Spectrum2_000677
    • AKOS003282656
    • Spectrum_001272
    • AB00052301_04
    • NCGC00094985-03
    • NCGC00094985-01
    • CHEBI:174162
    • D.O.T. (TN)
    • NINDS_000214
    • Zoalene (500 ug/mL in Methanol)
    • 3,5-Dinitro-2-methylbenzamide
    • SR-01000872611-3
    • Dinitolmide, VETRANAL(TM), analytical standard
    • IDI1_000214
    • EINECS 205-706-4
    • D07857
    • 148-01-6
    • HMS3652K20
    • BRD-K93240442-001-04-3
    • DB11480
    • Tox21_301320
    • Abilene
    • MFCD00072065
    • NSC758213
    • Dinitolmide (Zoalene)
    • HMS1922A07
    • VS-01441
    • Tox21_111374
    • 3,5-Dinitro-o-toluamide, 98%
    • SBI-0051752.P002
    • KBioGR_001024
    • Z971222254
    • Spectrum4_000732
    • BSPBio_002990
    • DINITOLMIDE [INN]
    • SMR001253784
    • DINITOLMIDE [MART.]
    • CS-4501
    • NCGC00094985-02
    • HSDB 7192
    • 2-Methyl-3,5-dinitrobenzamide, 9CI
    • DTXSID6042521
    • KBio2_004320
    • HMS3089A22
    • Zamix
    • BRD-K93240442-001-02-7
    • SPBio_000773
    • NSC-758213
    • SCHEMBL43712
    • CHEMBL472565
    • CCG-40029
    • FT-0614722
    • Coccidine
    • Spectrum5_001231
    • SPECTRUM1503036
    • UNII-AOX68RY4TV
    • NSC 758213
    • KBio2_001752
    • DINITOLMIDE [HSDB]
    • KBioSS_001752
    • KBio2_006888
    • SR-01000872611-2
    • ZEFNOZRLAWVAQF-UHFFFAOYSA-N
    • s4141
    • DivK1c_000214
    • NCGC00255914-01
    • Dinitolmide, BAN, INN
    • E77947
    • CAS-148-01-6
    • W-108109
    • SR-01000872611
    • Zoalele
    • ZOALENE [GREEN BOOK]
    • 2-methyl-3,5-dinitro-benzamide
    • KBio3_002490
    • Q4024614
    • Whitsyn T
    • 3-09-00-02316 (Beilstein Handbook Reference)
    • Spectrum3_001545
    • 3,5-Dinitro-ortho-toluamide
    • EN300-199771
    • NCGC00094985-05
    • HMS500K16
    • Raw Rehmannia Extract
    • 3,5Dinitrootoluamide
    • Benzamide, 2methyl3,5dinitro
    • ZoaShield 25%
    • BRD-K93240442-001-08-4
    • 2Methyl3,5dinitrobenzamide
    • USEPA/OPP Pesticide Code: 037510
    • Zoamix Type A Medicated Article
    • DB-021326
    • Dinitolmidum (INN-Latin)
    • Zoalene (ANSI)
    • STK395739
    • Dinitolmida (INN-Spanish)
    • DINITOLMIDE (MART.)
    • Zoalene 90 Medicated Coccidiostat
    • BBL003876
    • Dinitolmide (ACGIH)
    • 205-706-4
    • Dinitolmide
    • MDL： MFCD00072065
    • Inchi： 1S/C8H7N3O5/c1-4-6(8(9)12)2-5(10(13)14)3-7(4)11(15)16/h2-3H,1H3,(H2,9,12)
    • InChI Key： ZEFNOZRLAWVAQF-UHFFFAOYSA-N
    • SMILES： O=C(C1C=C(C=C(C=1C)[N+](=O)[O-])[N+](=O)[O-])N
    • BRN： 1990738

Computed Properties

  • Exact Mass: 225.03900
  • Monoisotopic Mass: 225.039
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 5
  • Heavy Atom Count: 16
  • Rotatable Bond Count: 1
  • Complexity: 321
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 2
  • XLogP3: 0.7
  • Topological Polar Surface Area: 135

Experimental Properties

  • Color/Form: Powder
  • Density: 1.5406 (rough estimate)
  • Melting Point: 170-180?°C (lit.)
  • Boiling Point: 366.66°C (rough estimate)
  • Flash Point: 2?°C
  • Refractive Index: 1.7400 (estimate)
  • PSA: 134.73000
  • LogP: 2.65700
  • Merck: 13,3297
  • FEMA: 3319
  • Solubility: Soluble in acetone, insoluble in water, slightly soluble in ethanol.
  • Vapor Pressure: 0.0±0.6 mmHg at 25°C

Dinitolmide Security Information

  • Symbol: GHS07
  • Signal Word：Warning
  • Hazard Statement： H302
  • Warning Statement： P280-P305+P351+P338
  • Hazardous Material transportation number：UN 1648 3/PG 2
  • WGK Germany：3
  • Hazard Category Code： 22
  • Safety Instruction： S26-S36-S16
  • RTECS：XS4200000
  • Hazardous Material Identification： Xn F
  • Risk Phrases：R22; R36; R20/21/22; R11
  • Storage Condition：2-8°C

Dinitolmide Customs Data

  • HS CODE：2309901000
  • Customs Data：

    China Customs Code:

    2924299090

    Overview:

    2924299090. Other cyclic amides(Including cyclic carbamates)(Including their derivatives as well as their salts). VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to, packing

    Summary:

    2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Dinitolmide Pricemore >>

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 148-01-6 98%
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TRC
Z584000-25mg
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 $ 68.00 2023-09-05
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 $ 119.00 2023-09-05
TRC
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 $ 153.00 2023-09-05

Dinitolmide Suppliers

Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:148-01-6)Dinitolmide
Order Number:sfd7997
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:34
Price ($):discuss personally
TAIXING JOXIN BIO-TEC CO.,LTD.
Gold Member
Audited Supplier Audited Supplier
(CAS:148-01-6)Dinitolmide
Order Number:JOX-032
Stock Status:in Stock
Quantity:25KG
Purity:98.500%
Pricing Information Last Updated:Tuesday, 15 July 2025 15:40
Price ($):
Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:148-01-6)Dinitolmide
Order Number:LE5633;LE12180
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 11:47
Price ($):discuss personally

Dinitolmide Related Literature

Related Categories

Additional information on Dinitolmide

Recent Advances in Dinitolmide (148-01-6) Research: A Comprehensive Review

Dinitolmide (CAS: 148-01-6), also known as Zoalene, is a well-known coccidiostat widely used in veterinary medicine to prevent and treat coccidiosis in poultry. Recent studies have focused on its pharmacological properties, mechanisms of action, and potential applications beyond its traditional use. This research brief aims to synthesize the latest findings on Dinitolmide, highlighting its chemical properties, biological activities, and emerging therapeutic potentials.

One of the key areas of recent research has been the elucidation of Dinitolmide's mechanism of action. Studies have confirmed that it primarily inhibits the mitochondrial electron transport chain in Eimeria species, the causative agents of coccidiosis. This disruption leads to energy depletion and subsequent parasite death. Advanced molecular modeling techniques have further refined our understanding of its binding interactions with key mitochondrial proteins, offering insights for the development of next-generation coccidiostats.

Beyond its antiparasitic effects, recent investigations have explored Dinitolmide's potential as an anticancer agent. In vitro studies have demonstrated its ability to induce apoptosis in certain cancer cell lines, particularly those with dysregulated mitochondrial function. While these findings are preliminary, they suggest a promising avenue for repurposing Dinitolmide in oncology, warranting further preclinical and clinical evaluation.

Another significant development is the optimization of Dinitolmide formulations to enhance bioavailability and reduce resistance. Novel nanoencapsulation techniques have been employed to improve its solubility and targeted delivery, addressing some of the limitations associated with its traditional use. These advancements could potentially extend its application to other parasitic diseases and improve its efficacy in existing indications.

In conclusion, Dinitolmide (148-01-6) continues to be a compound of significant interest in both veterinary and human medicine. Its well-established safety profile, combined with emerging therapeutic potentials, positions it as a versatile candidate for further research and development. Future studies should focus on exploring its broader pharmacological applications and addressing challenges related to drug resistance and formulation optimization.

148-01-6 (Dinitolmide) Related Products

Recommended suppliers
Suzhou Senfeida Chemical Co., Ltd
(CAS:148-01-6)Dinitolmide
sfd7997
Purity:99.9%
Quantity:200kg
Price ($):Inquiry
Email
TAIXING JOXIN BIO-TEC CO.,LTD.
(CAS:148-01-6)Dinitolmide
JOX-032
Purity:98.500%
Quantity:25KG
Price ($):Inquiry
Email