Production Method 1

4074-25-3

961-38-6

Reaction Conditions

1.1 Reagents: Triethylamine ,  Hydrogen Catalysts: Cobalt acetate tetrahydrate (complexes with phenanthroline, N doped graphene) Solvents: Ethanol ,  Water ;  55 h, 20 bar, 70 °C

Reference

Fe2O3/NGr@C- and Co-Co3O4/NGr@C-catalysed hydrogenation of nitroarenes under mild conditions

Formenti, Dario; Topf, Christoph; Junge, Kathrin; Ragaini, Fabio; Beller, Matthias, Catalysis Science & Technology, 2016, 6(12), 4473-4477

Production Method 2

4074-25-3

961-38-6

Reaction Conditions

1.1 Solvents: Ethanol

Reference

Steric effects on mesomerism. XVII. Properties of aromatic nitro, amino, and acylamino compounds with bulky ortho substituents

Burgers, J.; Hoefnagel, M. A.; Verkade, P. E.; Visser, H.; Wepster, B. M., Recueil des Travaux Chimiques des Pays-Bas et de la Belgique, 1958, 77, 491-530

Production Method 3

4074-25-3

961-38-6

Reaction Conditions

1.1 Reagents: Triethylamine ,  Hydrogen Catalysts: Cobalt oxide (Co3O4) (carbon-supported) ,  Cobalt (carbon-supported) Solvents: Ethanol ,  Water ;  15 h, 40 bar, 110 °C

Reference

Biomass-Derived Catalysts for Selective Hydrogenation of Nitroarenes

Sahoo, Basudev; Formenti, Dario; Topf, Christoph; Bachmann, Stephan; Scalone, Michelangelo; et al, ChemSusChem, 2017, 10(15), 3035-3039

Production Method 4

4074-25-3

961-38-6

Reaction Conditions

1.1 Reagents: Zinc ,  Hydrochloric acid Solvents: Ethanol ,  Ethyl acetate ;  0.5 h, rt; 4 h, rt → 70 °C
1.2 Reagents: Ammonia Solvents: Water ;  pH 7 - 8

Reference

Direct C-H heteroarylation by an acenaphthyl-based α-diimine palladium complex: improvement of the reaction efficiency for bi(hetero)aryls under aerobic conditions

Chen, Fu-Min; Huang, Fei-Dong; Yao, Xue-Yi; Li, Tian; Liu, Feng-Shou, Organic Chemistry Frontiers, 2017, 4(12), 2336-2342

Production Method 5

4074-25-3

961-38-6

Reaction Conditions

1.1 Reagents: Lithium aluminum hydride Solvents: Tetrahydrofuran ;  0 °C → rt; 15 min, rt; rt → reflux; 20 min, reflux; 10 min, heated; 3 h, reflux; reflux → 0 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ;  0 °C

Reference

Dichloro-Cycloazatriphosphane: The Missing Link between N2P2 and P4 Ring Systems in the Systematic Development of NP Chemistry

Bresien, Jonas ; Hinz, Alexander ; Schulz, Axel ; Suhrbier, Tim; Thomas, Max; et al, Chemistry - A European Journal, 2017, 23(59), 14738-14742

Production Method 6

58949-87-4

961-38-6

Reaction Conditions

1.1 Catalysts: Triphenylphosphine

Reference

Chemistry of N-(thiosulfinyl)anilines. V. Reactions of N-(thiosulfinyl)anilines with nucleophilic reagents

Inagaki, Yoshio; Hosogai, Takeo; Okazaki, Renji; Inamoto, Naoki, Bulletin of the Chemical Society of Japan, 1980, 53(1), 205-9

Production Method 7

961-38-6

Reaction Conditions

Reference

Chemistry of N-thiosulfinylanilines. II. Thermolysis and photolysis of N-thiosulfinylanilines

Inagaki, Yoshio; Okazaki, Renji; Inamoto, Naoki, Bulletin of the Chemical Society of Japan, 1979, 52(7), 2002-7

Production Method 8

961-38-6

Reaction Conditions

Reference

Sterically hindered aromatic compounds. VII. Deoxygenation of 2,5-di-tert-butyl- and 2,4,6-tri-tert-butylnitrosobenzene

Ross, L.; Barclay, C.; Khazanie, Prabhaker G.; Adams, Kenneth A. H.; Reid, Elaine, Canadian Journal of Chemistry, 1977, 55(18), 3273-9

Production Method 9

4074-25-3

961-38-6

Reaction Conditions

1.1 Reagents: Sodium amalgam Solvents: Ethanol

Reference

Studies in organosulphur-nitrogen and organoselenium-nitrogen chemistry

Setiloane, Busang Peter, 1979, , ,

Production Method 10

4074-25-3

961-38-6

Reaction Conditions

1.1 Reagents: Diethylene glycol dibutyl ether ,  Sodium borohydride Catalysts: 2409985-26-6 Solvents: Water ;  2 h, rt

Reference

Synthesis of water soluble Pd-Piperidoimidazolin-2-ylidene complexes and their catalytic activities in neat water

Cakir, Sinem; Tuerkmen, Hayati, Applied Organometallic Chemistry, 2020, 34(4),

Production Method 11

343971-98-2

961-38-6

Reaction Conditions

Reference

Oxidation of a 5H-1,2,3-dithiazole derivative. Formation of a new type of thiolsulfinate and its decomposition involving oxygen migration

Inagaki, Yoshio; Okazaki, Renji; Inamoto, Naoki, Chemistry Letters, 1978, (10), 1095-8

Production Method 12

24973-59-9

961-38-6

Reaction Conditions

1.1 Reagents: Triethylamine ,  Thiazolium, 2-(1-hydroxyethyl)-3,4-dimethyl-, 1,1,1-trifluoromethanesulfonate (1… Solvents: Dichloromethane ;  0.5 - 2 h, rt
1.2 Reagents: Sodium hydroxide Solvents: Water ;  rt
1.3 Reagents: Sodium hydride Solvents: Tetrahydrofuran ;  -30 °C
1.4 Reagents: Acetyl chloride ;  -30 °C → rt; rt

Reference

Reaction of aromatic nitroso compounds with chemical models of thiamine active aldehyde

Ferreira, Luisa M.; Marques, M. Manuel B.; Gloria, Paulo M. C.; Chaves, Humberto T.; Franco, Joao-Pedro P.; et al, Tetrahedron, 2008, 64(33), 7759-7770

Production Method 13

4074-25-3

961-38-6

Reaction Conditions

Reference

Reaction of 2,4,6-tri-tert-butylnitrobenzene with alkyl Grignard reagents

Inagaki, Yoshio; Okazaki, Renji; Inamoto, Naoki, Bulletin of the Chemical Society of Japan, 1975, 48(12), 3727-32

Production Method 14

4074-25-3

961-38-6

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Toluene ;  1 h, 80 °C

Reference

Efficient adjustment of product selectivity using controllable Pd nanoparticles in nitroarene hydrogenation

Zhang, Jian; Wang, Liang; Chen, Fang; Xiao, Feng-Shou, Particuology, 2020, 48, 13-18

Production Method 15

7377-26-6

116233-17-1

961-38-6

Reaction Conditions

1.1 Solvents: Benzene ,  Pyridine

Reference

Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity

Kagechika, Hiroyuki; Kawachi, Emiko; Hashimoto, Yuichi; Shudo, Koichi; Himi, Toshiyuki, Journal of Medicinal Chemistry, 1988, 31(11), 2182-92

Production Method 16

961-38-6

Reaction Conditions

Reference

Novel heterocumulenes: bisiminopropadienes and linear ketenimines

Wolf, Reinhard; Stadtmueller, Stefan; Wong, Ming Wah; Barbieux-Flammang, Monique; Flammang, Robert; et al, Chemistry - A European Journal, 1996, 2(10), 1318-1329

Production Method 17

961-38-6

Reaction Conditions

Reference

Picosecond laser photolysis studies of hydrogen-atom transfer reaction via heteroexcimer state in pyrene-primary and pyrene-secondary aromatic amine systems: role of hydrogen-bonding interaction between amino group of donor and π electrons of acceptor in the heteroexcimer

Okada, Tadashi; Karaki, Ichiro; Mataga, Noboru, Journal of the American Chemical Society, 1982, 104(25), 7191-5

Production Method 18

961-38-6

Reaction Conditions

Reference

Chemistry of N-thiosulfinylanilines. IV. Reactions of N-thiosulfinylanilines with electrophilic reagents

Inagaki, Yoshio; Okazaki, Renji; Inamoto, Naoki, Bulletin of the Chemical Society of Japan, 1979, 52(12), 3615-18

Production Method 19

961-38-6

Reaction Conditions

Reference

Reactions of 2,4,6-tri-tert-butylnitrosobenzene with Grignard reagents

Inagaki, Yoshio; Okazaki, Renji; Inamoto, Naoki, Bulletin of the Chemical Society of Japan, 1975, 48(2), 621-5

Production Method 20

961-38-6

Reaction Conditions

Reference

Photochemistry of aromatic nitro compounds. IX. Products from photolysis of 1,3,5-tri-tert-butyl-2-nitrobenzene

Doepp, Dietrich; Sailer, Karl H., Chemische Berichte, 1975, 108(1), 301-13

2,4,6-Tri-tert-butylaniline Raw materials

• 4-(Chlorocarbonyl)benzoic Acid Methyl Ester
• 7aH-1,2,3-Benzodithiazole, 4,6,7a-tris(1,1-dimethylethyl)-, 1-oxide
• 2,4,6-Tri-tert-Butylnitrosobenzene
• 3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-amine
• 4,6,7a-Tris(1,1-dimethylethyl)-7aH-1,2,3-benzodithiazole
• 2,4,6-Tri-tert-butylnitrobenzene

2,4,6-Tri-tert-butylaniline Preparation Products

• 2,4,6-Tri-tert-butylaniline (961-38-6)

• 1. Dissolution of cork biopolymers in biocompatible ionic liquids
  Helga Garcia,Rui Ferreira,Marija Petkovic,Jamie L. Ferguson,Maria C. Leit?o,H. Q. Nimal Gunaratne,Luís Paulo N. Rebelo Green Chem., 2010,12, 367-369
• 2. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
• 3. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 4. Fe3O4@PANI: a magnetic polyaniline nanomaterial for highly efficient and handy enrichment of intact N-glycopeptides??
  Zhizhen Lai,Mo Zhang,Jinyu Zhou,Tianjing Chen,Dan Li,Xuejing Shen,Jia Liu,Jiang Zhou,Zhili Li Analyst, 2021,146, 4261-4267
• 5. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylpropanes
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

• 35735-32-1(aniline, 2,4-dimethyl-6-tert-butyl-)
• 21860-03-7(2,5-Di-tert-butylaniline)
• 35532-73-1(2,4-di-tert-butyl-6-methylaniline)
• 2909-81-1(aniline, 2-tert-butyl-4-methyl-)
• 2909-84-4(2,4-Ditert-butylaniline)
• 6310-21-0(2-tert-butylaniline)
• 84282-24-6(4-(1,1-Dimethylethyl)-2,6-dimethylbenzene-1,3-diamine)
• 67330-60-3(aniline, 4-tert-butyl-2,6-diethyl-)
• 13117-94-7(2-tert-Butyl-6-methylaniline)
• 2909-80-0(aniline, 2,6-di-tert-butyl-4-methyl-)