- Preparation of the compounds used as NTRK inhibitor and medical application as anticancer agents, World Intellectual Property Organization, , ,
Cas no 959616-51-4 (5-Fluoro-2-methylnicotinaldehyde)
5-Fluoro-2-methylnicotinaldehyde is a fluorinated nicotinaldehyde derivative with a methyl substituent at the 2-position of the pyridine ring. This compound serves as a versatile intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and specialty chemicals. The presence of both the aldehyde and fluorine functional groups enhances its reactivity, enabling selective modifications for the construction of complex heterocyclic frameworks. Its structural features make it valuable for medicinal chemistry applications, including the development of bioactive molecules. The compound is typically handled under standard laboratory conditions, with purity and stability being critical for consistent performance in synthetic workflows.
959616-51-4 structure
Product Name:5-Fluoro-2-methylnicotinaldehyde
CAS No:959616-51-4
MF:C7H6FNO
MW:139.127045154572
CID:877641
Update Time:2025-10-11
5-Fluoro-2-methylnicotinaldehyde Chemical and Physical Properties
Names and Identifiers
-
- 5-Fluoro-2-methylnicotinaldehyde
- 5-fluoro-2-methyl-3-Pyridinecarboxaldehyde
- 5-fluoro-2-methylpyridine-3-carbaldehyde
- 5-Fluoro-2-methyl-3-pyridinecarboxaldehyde (ACI)
-
- Inchi： 1S/C7H6FNO/c1-5-6(4-10)2-7(8)3-9-5/h2-4H,1H3
- InChI Key： QWGOSSJWSWZNDE-UHFFFAOYSA-N
- SMILES： O=CC1C(C)=NC=C(F)C=1
Computed Properties
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 10
- Rotatable Bond Count: 1
5-Fluoro-2-methylnicotinaldehyde Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | F196104-50mg |
5-Fluoro-2-methylnicotinaldehyde |
959616-51-4 | 95% | 50mg |
￥901.90 | 2023-09-02 | |
| Alichem | A029006400-1g |
5-Fluoro-2-methylnicotinaldehyde |
959616-51-4 | 95% | 1g |
$760.87 | 2023-08-31 | |
| Alichem | A029006400-5g |
5-Fluoro-2-methylnicotinaldehyde |
959616-51-4 | 95% | 5g |
$2006.92 | 2023-08-31 | |
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | F849089-50mg |
5-Fluoro-2-methylnicotinaldehyde |
959616-51-4 | 95% | 50mg |
999.00 | 2021-05-17 | |
| Chemenu | CM177659-1g |
5-fluoro-2-methylnicotinaldehyde |
959616-51-4 | 95% | 1g |
$526 | 2021-08-05 | |
| Chemenu | CM177659-5g |
5-fluoro-2-methylnicotinaldehyde |
959616-51-4 | 95% | 5g |
$1389 | 2021-08-05 | |
| Chemenu | CM177659-1g |
5-fluoro-2-methylnicotinaldehyde |
959616-51-4 | 95% | 1g |
$633 | 2022-06-09 | |
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | F43880-50mg |
5-Fluoro-2-methylnicotinaldehyde |
959616-51-4 | - | 50mg |
￥978.0 | 2023-09-07 | |
| Crysdot LLC | CD11002613-100mg |
5-Fluoro-2-methylnicotinaldehyde |
959616-51-4 | 95+% | 100mg |
$140 | 2024-07-19 | |
| Crysdot LLC | CD11002613-250mg |
5-Fluoro-2-methylnicotinaldehyde |
959616-51-4 | 95+% | 250mg |
$223 | 2024-07-19 |
5-Fluoro-2-methylnicotinaldehyde Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: 2-Iodoxybenzoic acid Solvents: Ethyl acetate ; rt → 80 °C; 2.5 h, 80 °C
Reference
Production Method 2
Reaction Conditions
1.1 Reagents: 2-Iodoxybenzoic acid Solvents: Ethyl acetate ; rt → 80 °C; 2.5 h, 80 °C
Reference
- Preparation of pyrazole pyrimidine derivative and application as NTRK kinase inhibitors, China, , ,
Production Method 3
Reaction Conditions
1.1 Reagents: N-methylmorpholine N-oxide Solvents: Dichloromethane ; 30 min, rt
1.2 Catalysts: TPAP ; 1.5 h, rt
1.2 Catalysts: TPAP ; 1.5 h, rt
Reference
- Preparation of naphthyridinones and related compounds as antibacterial agents, Japan, , ,
5-Fluoro-2-methylnicotinaldehyde Raw materials
5-Fluoro-2-methylnicotinaldehyde Preparation Products
5-Fluoro-2-methylnicotinaldehyde Related Literature
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Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
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Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
-
Jing Yu,Yu-Qi Lyu,Jiapeng Liu,Mohammed B. Effat,Junxiong Wu J. Mater. Chem. A, 2019,7, 17995-18002
-
Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849
-
Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615
959616-51-4 (5-Fluoro-2-methylnicotinaldehyde) Related Products
- 1289109-24-5(5-fluoro-4-methylnicotinaldehyde)
- 113209-99-7(5-Fluoro-2,3-dimethylpyridine)
- 39891-04-8(5-fluoropyridine-3-carbaldehyde)
- 1060809-26-8(4-Fluoro-2-methylnicotinaldehyde)
- 780801-57-2(5-fluoro-3-methylpyridine-2-carbaldehyde)
- 917835-70-2(5-fluoro-6-methylpyridine-3-carbaldehyde)
- 1256785-71-3(1-(5-Fluoro-2-methylpyridin-3-yl)ethanone)
- 868636-57-1(methyl 5-fluoro-2-methylpyridine-3-carboxylate)
- 884494-96-6(6-fluoro-2-methylpyridine-3-carbaldehyde)
- 60032-57-7(2-methylpyridine-3-carboxaldehyde)
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