- Design and Synthesis of Novel Diaminoquinazolines with in Vivo Efficacy for β-Catenin/T-Cell Transcriptional Factor 4 Pathway InhibitionDehnhardt, Christoph M.; Venkatesan, Aranapakam M.; Chen, Zecheng; Ayral-Kaloustian, Semiramis; Dos Santos, Osvaldo; et al, Journal of Medicinal Chemistry, 2010, 53(2), 897-910
Cas no 959237-34-4 (2,4-Dichloro-7-iodoquinazoline)
959237-34-4 structure
Product Name:2,4-Dichloro-7-iodoquinazoline
CAS No:959237-34-4
MF:C8H3Cl2IN2
MW:324.93329167366
MDL:MFCD09954872
CID:820330
PubChem ID:34176200
Update Time:2025-10-05
2,4-Dichloro-7-iodoquinazoline Chemical and Physical Properties
Names and Identifiers
-
- 2,4-Dichloro-7-iodoquinazoline
- 2,4,5-TRIFLUOROPHENYLACETIC ACID
- 2,4-dichloro-7-iodo-quinazoline
- PubChem23096
- OAZYTNLOQKCMDG-UHFFFAOYSA-N
- Quinazoline, 2,4-dichloro-7-iodo-
- VZ22531
- FCH1396622
- AX8162996
- W9788
- ST24027312
- D12149
- 2,4-Dichloro-7-iodoquinazoline (ACI)
- AMY23479
- A858778
- AS-60145
- FT-0715631
- DTXSID90652956
- SCHEMBL4178672
- AKOS015851198
- AB92901
- F15686
- MFCD09954872
- 959237-34-4
- DB-080369
-
- MDL： MFCD09954872
- Inchi： 1S/C8H3Cl2IN2/c9-7-5-2-1-4(11)3-6(5)12-8(10)13-7/h1-3H
- InChI Key： OAZYTNLOQKCMDG-UHFFFAOYSA-N
- SMILES： IC1C=CC2=C(N=C(N=C2C=1)Cl)Cl
Computed Properties
- Exact Mass: 323.87200
- Monoisotopic Mass: 323.87180g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 13
- Rotatable Bond Count: 0
- Complexity: 193
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 25.8
- XLogP3: 4.1
Experimental Properties
- PSA: 25.78000
- LogP: 3.54120
2,4-Dichloro-7-iodoquinazoline Customs Data
- HS CODE：2933990090
- Customs Data：
China Customs Code:
2933990090Overview:
2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
2,4-Dichloro-7-iodoquinazoline Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Alichem | A189011156-5g |
2,4-Dichloro-7-iodoquinazoline |
959237-34-4 | 95% | 5g |
$990.00 | 2023-08-31 | |
| Alichem | A189011156-10g |
2,4-Dichloro-7-iodoquinazoline |
959237-34-4 | 95% | 10g |
$1466.30 | 2023-08-31 | |
| Alichem | A189011156-25g |
2,4-Dichloro-7-iodoquinazoline |
959237-34-4 | 95% | 25g |
$2333.10 | 2023-08-31 | |
| Fluorochem | 092151-250mg |
2,4-Dichloro-7-iodoquinazoline |
959237-34-4 | 95% | 250mg |
￡223.00 | 2022-03-01 | |
| Fluorochem | 092151-1g |
2,4-Dichloro-7-iodoquinazoline |
959237-34-4 | 95% | 1g |
￡555.00 | 2022-03-01 | |
| Chemenu | CM128450-1g |
2,4-dichloro-7-iodoquinazoline |
959237-34-4 | 95% | 1g |
$352 | 2021-08-05 | |
| Chemenu | CM128450-5g |
2,4-dichloro-7-iodoquinazoline |
959237-34-4 | 95% | 5g |
$795 | 2021-08-05 | |
| Chemenu | CM128450-10g |
2,4-dichloro-7-iodoquinazoline |
959237-34-4 | 95% | 10g |
$1062 | 2021-08-05 | |
| Chemenu | CM128450-25g |
2,4-dichloro-7-iodoquinazoline |
959237-34-4 | 95% | 25g |
$1772 | 2021-08-05 | |
| abcr | AB547877-250 mg |
2,4-Dichloro-7-iodoquinazoline; . |
959237-34-4 | 250MG |
€172.80 | 2023-07-11 |
2,4-Dichloro-7-iodoquinazoline Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: N,N-Dimethylaniline , Phosphorus oxychloride ; 6 h, 115 °C; 115 °C → 20 °C
1.2 Reagents: Ammonium hydroxide Solvents: Water ; pH 5 - 7
1.2 Reagents: Ammonium hydroxide Solvents: Water ; pH 5 - 7
Reference
Production Method 2
Reaction Conditions
1.1 Reagents: N,N-Dimethylaniline , Phosphorus oxychloride ; 6 h, 115 °C; 115 °C → rt
1.2 Reagents: Ammonium hydroxide Solvents: Water ; pH 5 - 7, cooled
1.2 Reagents: Ammonium hydroxide Solvents: Water ; pH 5 - 7, cooled
Reference
- Amino-substituted quinazoline derivatives as inhibitors of β-cantenin/Tcf-4 pathway and cancer treatment agents and their preparation, World Intellectual Property Organization, , ,
2,4-Dichloro-7-iodoquinazoline Raw materials
2,4-Dichloro-7-iodoquinazoline Preparation Products
2,4-Dichloro-7-iodoquinazoline Related Literature
-
Martin R. Ward,Gary W. Copeland,Andrew J. Alexander Chem. Commun., 2010,46, 7634-7636
-
J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
-
Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
959237-34-4 (2,4-Dichloro-7-iodoquinazoline) Related Products
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- 6625-94-1(2,4,7-Trichloroquinazoline)
- 351426-06-7(4-Chloro-6-iodo-2-methylquinazoline)
- 98436-53-4(Quinazoline,4-chloro-6,8-diiodo-)
- 62484-29-1(2,4,8-Trichloroquinazoline)
- 98556-31-1(4-Chloro-6-iodoquinazoline)
- 607-68-1(2,4-Dichloroquinazoline)
- 202197-78-2(4-Chloro-7-iodoquinazoline)
- 74173-76-5(2,4-Dichloro-6-iodoquinazoline)
- 134517-55-8(2,4,5-Trichloroquinazoline)
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