Production Method 1

6299-25-8

959070-42-9

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ;  -78 °C; 3 h, -78 °C
1.2 4 h, -78 °C; -78 °C → rt
1.3 Reagents: Ammonium chloride Solvents: Water

Reference

Preparation of substituted pyrazolo-pyrimidine compounds as antitumor agents

, United States, , ,

Production Method 2

6299-25-8

959070-42-9

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide Solvents: Ethylbenzene ,  Tetrahydrofuran ,  Heptane ;  20 min, -78 °C; 1 h, -78 °C
1.2 10 min, -78 °C; 1 h, -78 °C
1.3 Reagents: Ammonium chloride Solvents: Water

Reference

Hydroxamate compounds as antagonists of the adenosine A2a receptor and their preparation

, World Intellectual Property Organization, , ,

Production Method 3

6299-25-8

959070-42-9

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide Solvents: Ethylbenzene ,  Tetrahydrofuran ,  Heptane ;  1 h, -78 °C
1.2 2 h, -78 °C; -78 °C → rt
1.3 Reagents: Ammonium chloride Solvents: Water

Reference

Pyrimidine derivatives and their use use for the treatment of cancer

, World Intellectual Property Organization, , ,

Production Method 4

6299-25-8

623-49-4

959070-42-9

Reaction Conditions

1.1 Reagents: Magnesate(1-), dichloro(2,2,6,6-tetramethylpiperidinato)-, lithium (1:1) Solvents: Tetrahydrofuran
1.2 Solvents: Tetrahydrofuran

Reference

Regio- and Chemoselective Metalations of N-Heterocycles. Applications to the Synthesis of Biologically Active Compounds

Mosrin, Marc, 2009, , ,

Production Method 5

6299-25-8

623-49-4

959070-42-9

Reaction Conditions

1.1 Reagents: 2,2,6,6-Tetramethylpiperidine ,  Chloro(1-methylethyl)magnesium ,  Lithium chloride Solvents: Tetrahydrofuran ;  25 °C; 48 h, 25 °C
1.2 Solvents: Tetrahydrofuran ;  25 °C; 30 min, 25 °C
1.3 Solvents: Tetrahydrofuran ;  25 °C; 20 min, 25 °C
1.4 Reagents: Ammonium chloride Solvents: Water ;  25 °C

Reference

Regio- and chemoselective metalation of chloropyrimidine derivatives with TMPMgCl·LiCl and TMP2Zn·2MgCl2·2LiCl

Mosrin, Marc; Knochel, Paul, Chemistry - A European Journal, 2009, 15(6), 1468-1477

Production Method 6

6299-25-8

959070-42-9

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ,  Hexane ;  -78 °C; 1 h, -78 °C
1.2 Solvents: Tetrahydrofuran ;  -78 °C; 30 min, -78 °C; 30 min, 0 °C

Reference

Preparation of fused heterocyclic compounds as Smo (smoothened) inhibitors

, World Intellectual Property Organization, , ,

Ethyl 4,6-dichloro-2-(methylthio)pyrimidine-5-carboxylate Raw materials

• 4,6-Dichloro-2-(methylthio)pyrimidine
• 2-ethoxy-2-oxoacetonitrile

Ethyl 4,6-dichloro-2-(methylthio)pyrimidine-5-carboxylate Preparation Products

• Ethyl 4,6-dichloro-2-(methylthio)pyrimidine-5-carboxylate (959070-42-9)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Pyrimidinecarboxylic acids and derivatives

• 74840-34-9(4-Chloro-2-(methylthio)pyrimidine-5-carboxylic acid)
• 313339-35-4(4,6-dichloro-2-(methylsulfanyl)pyrimidine-5-carboxylic acid)
• 41103-17-7(Ethyl 4-chloropyrimidine-5-carboxylate)
• 6944-75-8(5-Pyrimidinecarboxylicacid, 4-chloro-2-[[(2,4-dichlorophenyl)methyl]thio]-, ethyl ester)
• 87600-72-4(Ethyl 4,6-dichloropyrimidine-5-carboxylate)
• 87600-71-3(Methyl 4,6-dichloropyrimidine-5-carboxylate)
• 87848-14-4(5-Pyrimidinecarboxylic acid, 2,4,6-trichloro-, ethyl ester)
• 5909-24-0(ethyl 4-chloro-2-(methylsulfanyl)pyrimidine-5-carboxylate)
• 2223-96-3(Ethyl 4-chloro-2-(ethylthio)pyrimidine-5-carboxylate)
• 38275-39-7(methyl 4-chloro-2-(methylsulfanyl)pyrimidine-5-carboxylate)