Production Method 1

956100-62-2

956100-63-3

Reaction Conditions

1.1 Reagents: Isoamyl nitrite Solvents: Tetrahydrofuran ;  220 min, 60 °C; 5 h, 60 °C; 60 °C → rt

Reference

Substituted 2-amino-fused heterocyclic compounds as JNK modulators and their preparation, pharmaceutical compositions and use in the treatment of diabetes and related diseases

, World Intellectual Property Organization, , ,

8-Bromo-2-chloroquinazoline Raw materials

• 8-Bromo-2-chloroquinazolin-4-amine

8-Bromo-2-chloroquinazoline Preparation Products

• 8-Bromo-2-chloroquinazoline (956100-63-3)

• 1. Enabling chloride salts for thermal energy storage: implications of salt purity?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazanaphthalenes Quinazolines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazanaphthalenes Benzodiazines Quinazolines

Comprehensive Overview of 8-Bromo-2-chloroquinazoline (CAS No. 956100-63-3): Properties, Applications, and Research Insights

8-Bromo-2-chloroquinazoline (CAS No. 956100-63-3) is a highly specialized heterocyclic compound belonging to the quinazoline family, which has garnered significant attention in pharmaceutical and agrochemical research. This compound features a bromine substitution at the 8-position and a chlorine atom at the 2-position, making it a versatile intermediate for synthesizing biologically active molecules. Its molecular formula, C₈H₄BrClN₂, and unique structural properties enable diverse applications in drug discovery and material science.

In recent years, the demand for 8-Bromo-2-chloroquinazoline has surged due to its role in developing kinase inhibitors and anticancer agents. Researchers frequently search for "quinazoline derivatives in drug design" or "CAS 956100-63-3 synthesis methods," reflecting its relevance in modern medicinal chemistry. The compound's electron-withdrawing groups (Br and Cl) enhance its reactivity in cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings, which are critical for constructing complex molecular architectures.

From an industrial perspective, 8-Bromo-2-chloroquinazoline is valued for its scalability and purity (>98%), meeting the stringent requirements of Good Manufacturing Practice (GMP). Laboratories often inquire about "buy 8-Bromo-2-chloroquinazoline high purity" or "956100-63-3 supplier," highlighting its commercial importance. Advanced analytical techniques like HPLC, NMR, and mass spectrometry are employed to validate its structural integrity, ensuring consistency across batches.

Environmental and regulatory considerations also play a pivotal role in the compound's usage. With growing interest in "green chemistry alternatives," researchers explore solvent-free or catalytic methods to synthesize 8-Bromo-2-chloroquinazoline sustainably. Its stability under ambient conditions and low ecotoxicity profile further bolster its adoption in eco-conscious applications.

Future prospects for CAS 956100-63-3 include its potential in photodynamic therapy and organic electronics, aligning with trends in "precision medicine" and "functional materials." As synthetic methodologies evolve, this compound is poised to remain a cornerstone in interdisciplinary research, bridging gaps between chemistry, biology, and engineering.

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