Production Method 1

161157-50-2

955028-82-7

Reaction Conditions

1.1 Reagents: Triethylamine trihydrofluoride Solvents: 1,2-Dichloroethane ;  18 h, 80 °C; 80 °C → rt
1.2 Reagents: Sodium bicarbonate Solvents: Dichloromethane ,  Water

Reference

Preparation of pyrrolopyridines as checkpoint kinase CHK1 and/or CHK2 inhibitors.

, World Intellectual Property Organization, , ,

Production Method 2

955028-82-7

Reaction Conditions

Reference

Novel diazepane derivatives as CCR2 antagonists and their preparation, pharmaceutical compositions an use in the treatment of diseases

, United States, , ,

Production Method 3

161157-50-2

955028-82-7

955029-44-4

Reaction Conditions

1.1 Reagents: Triethylamine trihydrofluoride ;  rt → 80 °C; overnight, 80 °C

Reference

Mono- and Difluorinated Saturated Heterocyclic Amines for Drug Discovery: Systematic Study of Their Physicochemical Properties

Melnykov, Kostiantyn P.; Nazar, Kostiantyn; Smyrnov, Oleh; Skreminskyi, Artem; Pavlenko, Serhii; et al, Chemistry - A European Journal, 2023, 29(47),

Production Method 4

161157-50-2

955028-82-7

955029-44-4

Reaction Conditions

1.1 Reagents: Triethylamine trihydrofluoride Solvents: 1,2-Dichloroethane ;  12 h, rt → 80 °C

Reference

Preparation of diazepanone compounds as chemokine receptor antagonists for treatment of inflammatory diseases

, United States, , ,

tert-butyl trans-4-fluoro-3-hydroxy-piperidine-1-carboxylate Raw materials

• Tert-Butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate

tert-butyl trans-4-fluoro-3-hydroxy-piperidine-1-carboxylate Preparation Products

• tert-butyl trans-4-fluoro-3-hydroxy-piperidine-1-carboxylate (955028-82-7)
• tert-butyl trans-3-fluoro-4-hydroxypiperidine-1-carboxylate (955029-44-4)

• 1. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
• 2. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 3. Enantiomeric two-fold interpenetrated 3D zinc(ii) coordination networks as a catalytic platform: significant difference between water within the cage and trace water in transesterification?
  Eunkyung Choi,Minjoo Ryu,Haeri Lee,Ok-Sang Jung Dalton Trans., 2017,46, 4595-4601
• 4. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
• 5. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidinecarboxylic acids and derivatives Piperidinecarboxylic acids

• 1174020-46-2(2-Methyl-2-propanyl (3S,4R)-4-fluoro-3-hydroxy-1-piperidinecarboxylate)
• 1174020-50-8(Tert-butyl (3R,4R)-3-fluoro-4-hydroxypyrrolidine-1-carboxylate)
• 1174020-45-1(tert-butyl (3S,4S)-4-fluoro-3-hydroxy-piperidine-1-carboxylate)
• 1186688-52-7(tert-butyl 4,4-difluoro-3-hydroxypiperidine-1-carboxylate)
• 1260772-97-1(tert-Butyl 4-fluoro-3-hydroxypiperidine-1-carboxylate)
• 1174020-49-5(tert-butyl (3R,4S)-3-fluoro-4-hydroxypyrrolidine-1-carboxylate)
• 1379325-25-3(Tert-butyl 3-fluoro-4-hydroxypyrrolidine-1-carboxylate)
• 2055223-76-0(tert-butyl cis-3-fluoro-4-hydroxypyrrolidine-1-carboxylate)
• 869481-93-6(tert-butyl trans-3-fluoro-4-hydroxypyrrolidine-1-carboxylate)
• 1174020-48-4(tert-butyl (3S,4R)-3-fluoro-4-hydroxypyrrolidine-1-carboxylate)