Production Method 1

327046-79-7

954239-15-7

Reaction Conditions

1.1 Reagents: Iron ,  Ammonium chloride Solvents: Tetrahydrofuran ,  Water ;  17 h, rt

Reference

Phenyl-sulfamoyl benzoic acids as ERAP1 modulators and preparation

, World Intellectual Property Organization, , ,

Production Method 2

327046-79-7

954239-15-7

Reaction Conditions

1.1 Reagents: Zinc ,  Ammonium chloride Solvents: Dimethylformamide ,  Water ;  2 h, 80 °C

Reference

Preparation of 1,2,3-triazole compound as histone deacetylase inhibitor

, World Intellectual Property Organization, , ,

Production Method 3

327046-79-7

954239-15-7

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Catalysts: Iron chloride (FeCl3) Solvents: Methanol ,  Water ;  rt; 3 h, reflux

Reference

Synthesis and molecular modeling studies of novel tert-butyl 2,4-disubstituted carboxamido phenylcarbamate derivatives and evaluation of their antimicrobial activity

Pochampally, Jalapathi; Valeru, Anil; Macha, Ramesh; Bhavani, A. K. D.; Nalla, Umapathi; et al, Pharma Chemica, 2014, 6(1), 61-76

Production Method 4

327046-79-7

954239-15-7

Reaction Conditions

1.1 Reagents: Zinc ,  Ferrous sulfate heptahydrate ,  Ammonium chloride Solvents: Ethanol ,  Water ;  rt → 50 °C; 3 h, 50 °C

Reference

Preparation of benzodiazepinones as metabotropic glutamate receptor modulators useful in the treatment of CNS disorders

, World Intellectual Property Organization, , ,

Production Method 5

327046-79-7

954239-15-7

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethyl acetate

Reference

Image-Guided Synthesis Reveals Potent Blood-Brain Barrier Permeable Histone Deacetylase Inhibitors

Seo, Young Jun; Kang, Yeona; Muench, Lisa; Reid, Alicia; Caesar, Shannon; et al, ACS Chemical Neuroscience, 2014, 5(7), 588-596

Production Method 6

327046-79-7

954239-15-7

Reaction Conditions

1.1 Reagents: Zinc ,  Ammonium chloride Solvents: Methanol ,  Water ;  30 min, 80 °C; 2 h, rt

Reference

Design, synthesis and evaluation of anti-tumor activities of chidamide derivatives

Zhang, Xiangna; He, Feng; Zhang, Qiuqiong; Lu, Jiahui; Xu, A-na; et al, Youji Huaxue, 2019, 39(7), 1983-1989

Production Method 7

327046-79-7

954239-15-7

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Catalysts: Iron chloride (FeCl3) Solvents: Methanol ;  rt → reflux; 3 h, reflux

Reference

Synthesis, characterization and antibacterial evaluation of few 2,3-substituted quinoxalines

Reddy, B. Jayachandra; Reddy, M. C. Somasekhara, Journal of the Chilean Chemical Society, 2010, 55(4), 483-485

Production Method 8

24424-99-5

1575-37-7

954239-15-7

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Tetrahydrofuran ;  overnight, rt

Reference

Nitrogen-containing heterocyclic derivative, neuroprotective agent, and pharmaceutical composition for cancer treatment

, World Intellectual Property Organization, , ,

Production Method 9

24424-99-5

1575-37-7

954239-15-7

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: Acetonitrile ;  15 min, rt
1.2 2 h, rt

Reference

Synthesis of 2-Alkoxy/Thioalkoxy Benzo[d]imidazoles and 2-Thione Benzo[d]imidazoles via a Phase-Based, Chemoselective Reaction

Yoon, Hyo-Jeong; Yang, Seung-Ju; Gong, Young-Dae, ACS Combinatorial Science, 2017, 19(12), 738-747

Production Method 10

327046-79-7

954239-15-7

Reaction Conditions

1.1 Reagents: Iron Solvents: Acetic acid ;  rt; 30 min, reflux

Reference

Heteroaryl compounds as metabotropic glutamate receptor negative allosteric modulators and their preparation

, World Intellectual Property Organization, , ,

Production Method 11

24424-99-5

875-51-4

954239-15-7

Reaction Conditions

1.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: Tetrahydrofuran ;  72 h, rt
1.2 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ;  rt → 0 °C; 0 °C; 48 h, 0 °C
1.3 Reagents: Sodium hydroxide Solvents: Water ;  pH 7
1.4 Reagents: Zinc ,  Ammonium chloride Solvents: Dimethylformamide ,  Water ;  30 min, 80 °C; 2 h, rt

Reference

Benzimidazole derivatives, method for the production thereof, their use as FXR agonists and pharmaceutical preparations containing the same

, World Intellectual Property Organization, , ,

(2-AMINO-4-BROMO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER Raw materials

• Di-tert-butyl dicarbonate
• N-(4-Bromo-2-nitrophenyl)carbamic Acid tert-Butyl Ester
• 4-Bromo-2-nitroaniline
• 4-Bromobenzene-1,2-diamine

(2-AMINO-4-BROMO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products

• (2-AMINO-4-BROMO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER (954239-15-7)

• 1. An Assessment of the Laminar Hypersonic Double-Cone Experiments in the LENS-XX Tunnel
  JaideepRay,PatrickBlonigan,EricT.Phipps,KathrynMaupin
• 2. An intensified π-hole in beryllium-doped boron nitride meshes: its determinant role in CO2 conversion into hydrocarbon fuels?
  Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551
• 3. Aluminium alkyl and aryloxide complexes of pyrazine and bipyridines: synthesis and structure?
  Doug Ogrin,Laura H. van Poppel,Simon G. Bott,Andrew R. Barron Dalton Trans., 2004, 3689-3694
• 4. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
• 5. An autonomous self-optimizing flow machine for the synthesis of pyridine–oxazoline (PyOX) ligands?
  Eric Wimmer,Daniel Cortés-Borda,Solène Brochard,Elvina Barré,Charlotte Truchet,Fran?ois-Xavier Felpin React. Chem. Eng., 2019,4, 1608-1615

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylcarbamic acid esters

• 195134-70-4(Carbamic acid, (3,5-dibromophenyl)-, 1,1-dimethylethyl ester)
• 57598-34-2(Tert-Butyl 3-Bromophenyl(Methyl)Carbamate)
• 2610-65-3(Carbamic acid,(3-bromophenyl)-, 1-methylethyl ester (9CI))
• 40427-42-7(propan-2-yl (4-bromophenyl)carbamate)
• 25216-74-4(tert-Butyl N-(3-Bromophenyl)carbamate)
• 869114-68-1(tert-Butyl (6-bromonaphthalen-2-yl)carbamate)
• 1017781-88-2((2-Amino-6-bromo-phenyl)-carbamic Acid tert-Butyl Ester)
• 954238-73-4((2-AMINO-3-BROMO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER)
• 1405128-28-0(Tert-butyl N-(3-bromo-5-methylphenyl)carbamate)
• 131818-17-2(tert-Butyl 4-Bromophenylcarbamate)