Production Method 1

98-88-4

954-16-5

Reaction Conditions

1.1 Catalysts: Iron oxide (Fe2O3) ;  3 h, 110 °C

Reference

An efficient Fe2O3/HY catalyst for Friedel-Crafts acylation of m-xylene with benzoyl chloride

Mu, Manman; Chen, Ligong; Liu, Yunlong; Fang, Wangwang; Li, Yang, RSC Advances, 2014, 4(70), 36951-36958

Production Method 2

98-88-4

954-16-5

Reaction Conditions

1.1 Reagents: Iodine ,  Phosphorus trichloride ;  36 h, 160 °C

Reference

Iodine Promoted Conversion of Esters to Nitriles and Ketones under Metal-Free Conditions

Xiao, Jing ; Guo, Fengzhe; Li, Yinfeng; Li, Fangshao; Li, Qiang ; et al, Journal of Organic Chemistry, 2021, 86(2), 2028-2035

Production Method 3

1804967-87-0

5980-97-2

954-16-5

Reaction Conditions

1.1 Reagents: Sodium carbonate Catalysts: Palladium diacetate ,  Phosphine, tricyclohexyl-, tetrafluoroborate(1-) (1:1) Solvents: 1,4-Dioxane ;  rt; 15 h, 120 °C

Reference

Sterically Hindered Ketones via Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling of Amides by N-C(O) Activation

Liu, Chengwei ; Lalancette, Roger ; Szostak, Roman; Szostak, Michal, Organic Letters, 2019, 21(19), 7976-7981

Production Method 4

98-88-4

954-16-5

Reaction Conditions

1.1 Catalysts: Potassium chloride (PIZP-catalyst) ,  Phosphoric acid (PIZP-catalyst) ,  Zirconium oxychloride (PIZP-catalyst) ,  Iron chloride (FeCl3) (PIZP-catalyst) ;  2.5 h, 110 °C

Reference

A novel sol-gel synthesized catalyst for Friedel-Crafts benzoylation reaction under solvent-free conditions

Gawande, M. B.; Deshpande, S. S.; Sonavane, S. U.; Jayaram, R. V., Journal of Molecular Catalysis A: Chemical, 2005, 241(1-2), 151-155

Production Method 5

36967-85-8

954-16-5

Reaction Conditions

Reference

Electrophilic aromatic substitution. 25. Carboxylic trifluoromethanesulfonic anhydrides as highly effective acylation agents. Perfluoroalkanesulfonic acid catalyzed acylation of arenes

Effenberger, Franz; Sohn, Erich; Epple, Gerhard, Chemische Berichte, 1983, 116(3), 1195-208

Production Method 6

65-85-0

954-16-5

Reaction Conditions

1.1 Reagents: Benzotrichloride Catalysts: Iron oxide (Fe2O3), hydrate (1:2) ;  8 h, 0.18 MPa, 125 °C

Reference

Preparation of benzophenone derivatives

, China, , ,

Production Method 7

98-88-4

954-16-5

Reaction Conditions

1.1 Catalysts: Bismuth triflate Solvents: 1-Butyl-3-methylimidazolium trifluoromethanesulfonate ;  30 min, 140 °C

Reference

Improvement of the Friedel-Crafts benzoylation by using bismuth trifluoromethanesulfonate in 1-butyl-3-methylimidazolium trifluoromethanesulfonate ionic liquid under microwave irradiation

HoangTran, Phuong; BichLe Do, Ngoc; NgocLe, Thach, Tetrahedron Letters, 2014, 55(1), 205-208

Production Method 8

98-88-4

954-16-5

Reaction Conditions

1.1 Catalysts: Hydrochloric acid ,  Uranyl chloride Solvents: Water

Reference

Acylation of aromatic compounds

, France, , ,

Production Method 9

65-85-0

954-16-5

Reaction Conditions

1.1 Reagents: Trifluoroacetic anhydride Catalysts: Bismuth triflate ;  0 °C; 12 h, 30 °C

Reference

The Friedel-Crafts acylation of aromatic compounds with carboxylic acids by the combined use of perfluoroalkanoic anhydride and bismuth or scandium triflate

Matsushita, Yoh-Ichi; Sugamoto, Kazuhiro; Matsui, Takanao, Tetrahedron Letters, 2004, 45(24), 4723-4727

Production Method 10

98-88-4

954-16-5

Reaction Conditions

1.1 Catalysts: Copper iron oxide (CuFe2O4) ;  18 h, 35 - 38 °C

Reference

Catalytic Friedel-Crafts acylation: magnetic nanopowder CuFe2O4 as an efficient and magnetically separable catalyst

Parella, Ramarao; Naveen; Kumar, Amit; Babu, Srinivasarao Arulananda, Tetrahedron Letters, 2013, 54(13), 1738-1742

Production Method 11

98-88-4

954-16-5

Reaction Conditions

1.1 Catalysts: Tetrakis[1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-N-[(1,1,2,2,3,3,4,4,5… Solvents: Chlorobenzene ;  3 h, 110 °C; 1 h, 100 °C

Reference

Hf[N(SO2C8F17)2]4-catalyzed Friedel-Crafts acylation in a fluorous biphase system

Hao, Xiuhua; Yoshida, Akihiro; Nishikido, Joji, Tetrahedron Letters, 2005, 46(15), 2697-2700

Production Method 12

65-85-0

954-16-5

Reaction Conditions

1.1 Reagents: Trifluoroacetic acid ,  2-Pyridyl triflate Solvents: Trifluoroacetic acid

Reference

2-(Trifluoromethylsulfonyloxy)pyridine as a reagent for ketone synthesis from carboxylic acids and aromatic hydrocarbons

Keumi, Takashi; Yoshimura, Kiichiro; Shimada, Masakazu; Kitajima, Hidehiko, Bulletin of the Chemical Society of Japan, 1988, 61(2), 455-9

Production Method 13

934-56-5

938-18-1

954-16-5

Reaction Conditions

1.1 Catalysts: 2623973-37-3 Solvents: Benzene-d6 ;  rt → 75 °C; 12 h, 75 °C

Reference

Phosphine-Borane Ligands Induce Chemoselective Activation and Catalytic Coupling of Acyl Chlorides at Palladium

Boudjelel, Maxime; Sadek, Omar ; Mallet-Ladeira, Sonia; Garcia-Rodeja, Yago; Sosa Carrizo, E. Daiann ; et al, ACS Catalysis, 2021, 11(7), 3822-3829

Production Method 14

2633-66-1

155632-06-7

954-16-5

Reaction Conditions

1.1 Solvents: Tetrahydrofuran ;  5 min, -15 °C; 3 h, -15 °C → rt
1.2 Reagents: Ammonium chloride Solvents: Water ;  rt

Reference

6-methyl-2,4-pyrimidyl diesters. A highly efficient acylating agent for the synthesis of unsymmetrical ketones

Lee, Jae In, Bulletin of the Korean Chemical Society, 2010, 31(3), 749-752

2,4,6-Trimethylbenzophenone Raw materials

• Trimethylphenyltin
• Benzoic acid
• 2,6-Piperidinedione, 1-benzoyl-
• Benzoyl Trifluoromethanesulfonate
• 2,4,6-Trimethylphenylboronic acid
• 2,4,6-Trimethylbenzoyl cloride
• Benzoyl chloride
• Magnesium,bromo(2,4,6-trimethylphenyl)-
• 2,4-Pyrimidinediol, 6-methyl-, 2,4-dibenzoate

2,4,6-Trimethylbenzophenone Preparation Products

• 2,4,6-Trimethylbenzophenone (954-16-5)

• 1. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699
• 2. An amorphous Cu–In–S nanoparticle-based precursor ink with improved atom economy for CuInSe2 solar cells with 10.85% efficiency?
  Green Chem., 2017,19, 1268-1277
• 3. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
  Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
• 4. An insight into the origin of room-temperature ferromagnetism in SnO2 and Mn-doped SnO2 quantum dots: an experimental and DFT approach?
  Dhamodaran Manikandan,S. Amirthapandian,I. S. Zhidkov,A. I. Kukharenko,S. O. Cholakh,Ramaswamy Murugan Phys. Chem. Chem. Phys., 2018,20, 6500-6514
• 5. An amino group functionalized metal–organic framework as a luminescent probe for highly selective sensing of Fe3+ ions?
  Zhonghua Xiang,Chuanqi Fang,Sanhua Leng,Dapeng Cao J. Mater. Chem. A, 2014,2, 7662-7665

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzophenones

• 3478-88-4(2,2',4,4'-Tetramethylbenzophenone)
• 1322-78-7(Methanone,(dimethylphenyl)phenyl- (9CI))
• 13319-69-2(Methanone,(2,3-dimethylphenyl)phenyl-)
• 35019-06-8(Methanone,(2,5-dimethylphenyl)(2,4,6-trimethylphenyl)-)
• 30424-58-9(Ethanone,1-(benzoylphenyl)- (9CI))
• 154618-97-0(5H-Nonabenzo[a,d,g,j,m,p,s,v,y]cycloheptacosene-5,10,15,20,25,30,35,40,45-nonone)
• 154618-95-8(5H-Pentabenzo[a,d,g,j,m]cyclopentadecene-5,10,15,20,25-pentone)
• 1139-60-2(Methanone,(2,6-dimethylphenyl)phenyl-)
• 1024-64-2(Methanone,(2-methylphenyl)(2,4,6-trimethylphenyl)-)
• 154618-96-9(5H-Heptabenzo[a,d,g,j,m,p,s]cycloheneicosene-5,10,15,20,25,30,35-heptone)