Production Method 1

821-48-7

95356-15-3

Reaction Conditions

1.1 Solvents: 1-Butanol ;  20 h, 130 °C
1.2 Reagents: Sodium bicarbonate ;  30 h, 130 °C

Reference

Synthesis of monoalkyl substituted phenylpiperazine derivatives

Bai, Baoqing; Yuan, Mu; Zhou, Xin, Jingxi Huagong, 2007, 24(8), 823-825

Production Method 2

821-48-7

95356-15-3

Reaction Conditions

1.1 Solvents: 1-Butanol ;  rt; 24 h, reflux
1.2 Reagents: Potassium carbonate ;  48 h, reflux

Reference

Design, synthesis, and biological evaluation of structurally constrained hybrid analogues containing ropinirole moiety as a novel class of potent and selective dopamine D3 receptor ligands

Zhou, Benhua; Hong, Kwon Ho; Ji, Min; Cai, Jin, Chemical Biology & Drug Design, 2018, 92(3), 1597-1609

Production Method 3

821-48-7

95356-15-3

Reaction Conditions

1.1 Solvents: Diethylene glycol monomethyl ether ;  4 min

Reference

Synthesis of N-aryl piperazinium chlorides under microwave irradiation

Fu, Li-xiang; Xu, Chong-fu; Lu, Hai-ling; Zheng, Huang-li; Zhao, Meng-meng; et al, Jingxi Huagong, 2013, 30(7), 816-820

Production Method 4

821-48-7

95356-15-3

Reaction Conditions

1.1 Solvents: tert-Butanol ;  rt; 24 h, reflux
1.2 Reagents: Potassium carbonate ;  48 h, reflux

Reference

Design, synthesis and biological evaluation of bitopic arylpiperazine-hexahydro-pyrazinoquinolines as preferential dopamine D3 receptor ligands

Zhou, Benhua; Ji, Min; Cai, Jin, Bioorganic Chemistry, 2018, 77, 125-135

Production Method 5

334-22-5

95356-15-3

Reaction Conditions

1.1 Solvents: 1-Butanol ;  24 h, 115 °C
1.2 Reagents: Sodium carbonate ;  22 h, 115 °C

Reference

Study on synthesis of 2-piperazinyl-4-phenylpyrimidine derivatives

Meng, Qi; Jiang, Nan; Jiang, Yan; Zhou, Changqing; Sun, Xiaoqiang, Huaxue Tongbao, 2013, 76(7), 624-629

Production Method 6

95356-15-3

Reaction Conditions

Reference

Preparation of dihydroindol-2-one as the D3 receptor ligand

, China, , ,

Production Method 7

95356-15-3

Reaction Conditions

Reference

Hexahydro-pyrazino quinolines D3 acceptor ligand, preparation method and application thereof

, China, , ,

1-(o-Tolyl)piperazine hydrochloride Raw materials

• bis(2-chloroethyl)amine
• Bis(2-chloroethyl)amine hydrochloride

1-(o-Tolyl)piperazine hydrochloride Preparation Products

• 1-(o-Tolyl)piperazine hydrochloride (95356-15-3)

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• 39512-51-1(1-(2-Methylphenyl)-piperazine)
• 1013-25-8(1-(2,5-Dimethylphenyl)piperazine)
• 1012-91-5(1-(2,6-Dimethylphenyl)piperazine)
• 3367-47-3(Piperazine,1,4-bis(2-methylphenyl)-)
• 5464-90-4(Piperazine,1-methyl-4-(2-methylphenyl)-)
• 1177349-04-0(3-methyl-4-(4-methylpiperazin-1-yl)aniline;dihydrochloride)
• 58334-09-1(2-(4-o-Tolyl-piperazin-1-yl)ethylamine)
• 55974-34-0(1-(2-Methylphenyl)piperazine Dihydrochloride)
• 70849-60-4(1-(o-Tolyl)piperazine Hydrochloride)
• 1013-76-9(1-(2,4-Dimethylphenyl)Piperazine)