Production Method 1

1036756-12-3

953040-63-6

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  5 h, 130 °C

Reference

Preparation of substituted acrylamides as inhibitors of the fibroblast growth factor receptor

, World Intellectual Property Organization, , ,

Production Method 2

1036756-12-3

953040-63-6

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  3 h, rt → 110 °C

Reference

2-Arylaminoquinazolines as PDKI inhibitors and their preparation and use in the treatment of proliferative diseases

, World Intellectual Property Organization, , ,

Production Method 3

1036756-12-3

953040-63-6

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  5 h, 130 °C; 130 °C → rt
1.2 Reagents: Water ;  cooled

Reference

Preparation of 6-phenylquinazoline derivatives and related heterocyclic compounds as inhibitors of fibroblast growth factor receptor-4 (FGFR-4)

, World Intellectual Property Organization, , ,

Production Method 4

1036756-12-3

953040-63-6

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  3 h, rt → 110 °C

Reference

Preparation of quinazolines for PDK1 inhibition

, World Intellectual Property Organization, , ,

6-Bromo-2-chloro-7-methoxyquinazoline Raw materials

• 6-bromo-7-methoxy-1,2-dihydroquinazolin-2-one

6-Bromo-2-chloro-7-methoxyquinazoline Preparation Products

• 6-Bromo-2-chloro-7-methoxyquinazoline (953040-63-6)

• 1. An amphipathic trans-acting phosphorothioate RNA element delivers an uncharged phosphorodiamidate morpholino sequence in mdx mouse myotubes?
  H. V. Jain,D. Verthelyi,S. L. Beaucage RSC Adv., 2017,7, 42519-42528
• 2. An AuNPs-functionalized AlGaN/GaN high electron mobility transistor sensor for ultrasensitive detection of TNT?
  Ying Li,Weirong Yao,Yunfei Xie,Renjun Pei RSC Adv., 2015,5, 98724-98729
• 3. An approach to C–N activation: coupling of arenesulfonyl hydrazides and arenesulfonyl chlorides with tert-amines via a metal-, oxidant- and halogen-free anodic oxidation??
  M. Sheykhan,S. Khani,S. Shaabanzadeh,M. Joafshan Green Chem., 2017,19, 5940-5948
• 4. An insight into the origin of room-temperature ferromagnetism in SnO2 and Mn-doped SnO2 quantum dots: an experimental and DFT approach?
  Dhamodaran Manikandan,S. Amirthapandian,I. S. Zhidkov,A. I. Kukharenko,S. O. Cholakh,Ramaswamy Murugan Phys. Chem. Chem. Phys., 2018,20, 6500-6514
• 5. An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening
  Chengbin Yang,Hing Lun Tsang,Pui Man Lau,Ken-Tye Yong,Ho Pui Ho,Siu Kai Kong Analyst, 2017,142, 3579-3587

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazanaphthalenes Quinazolines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazanaphthalenes Benzodiazines Quinazolines

• 1647114-77-9(6-Bromo-7-methoxyquinazoline)
• 1388046-75-0(5-bromo-2-chloro-8-methoxy-quinazoline)
• 2570190-10-0(8-Quinazolinol, 5,7-dibromo-2-chloro-)
• 953039-14-0(6-Bromo-2-chloro-8-methoxyquinazoline)
• 1894107-51-7(5-(2-bromophenoxy)-2-chloropyrimidine)
• 64778-11-6(QUINAZOLINE, 2-CHLORO-4-(2,4,6-TRIBROMOPHENOXY)-)
• 1256955-27-7(6-bromo-4-chloro-7-methoxyquinazoline)
• 953039-88-8(7-Bromo-2,5-dichloro-8-methoxyquinazoline)
• 1388042-80-5(8-bromo-2-chloro-6-methoxyquinazoline)
• 64778-10-5(Quinazoline, 2-chloro-4-(2,4-dibromophenoxy)-)