Production Method 1

952138-18-0

952138-19-1

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  3 h, rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  pH 8, cooled

Reference

Arylaminophthalazine derivatives as Aurora kinase modulators and their preparation

, United States, , ,

Production Method 2

952138-18-0

952138-19-1

Reaction Conditions

1.1 Reagents: Diisopropylethylamine ,  Phosphorus oxychloride Solvents: Acetonitrile ;  rt; 30 min, 70 °C; 70 °C → rt
1.2 Reagents: Water ;  cooled
1.3 Reagents: Sodium hydroxide Solvents: Water ;  pH 8

Reference

Pyrido-azaheterocyclic compound as kinase inhibitor and its preparation

, China, , ,

Production Method 3

952138-18-0

952138-19-1

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  3 h, rt
1.2 Reagents: Sodium carbonate Solvents: Water ;  cooled; pH 8

Reference

Fused heterocyclic derivatives as HGF modulators and their preparation and methods of use

, United States, , ,

Production Method 4

952138-18-0

952138-19-1

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  3 h, rt
1.2 Reagents: Water ;  cooled

Reference

Phatalazinamine derivatives and related compounds as aurora kinase modulators and their preparation, pharmaceutical compositions and use in the treatment or cancer and cancer related diseases

, World Intellectual Property Organization, , ,

Production Method 5

952138-18-0

952138-19-1

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  3 h, rt
1.2 Reagents: Sodium carbonate Solvents: Water ;  pH 8, cooled

Reference

Preparation of fused heterocyclic derivatives for treating HGF mediated diseases

, World Intellectual Property Organization, , ,

Production Method 6

952138-18-0

952138-19-1

Reaction Conditions

1.1 Reagents: Diisopropylethylamine ,  Phosphorus oxychloride Solvents: 1,4-Dichlorobenzene ;  rt → 10 °C; 1.5 h, 10 °C → 70 °C; 70 °C → rt

Reference

Preparation of naphthyridine derivatives as anti-cancer agents

, World Intellectual Property Organization, , ,

4-Chloro-7-methoxy-1,6-naphthyridine Raw materials

• 7-methoxy-1,4-dihydro-1,6-naphthyridin-4-one

4-Chloro-7-methoxy-1,6-naphthyridine Preparation Products

• 4-Chloro-7-methoxy-1,6-naphthyridine (952138-19-1)

• 1. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
  Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
• 2. Acenaphthenic hopanoids, a novel series of aromatised
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• 3. An anti-leakage liquid metal thermal interface material
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• 4. An atomically efficient, highly stable and redox active Ce0.5Tb0.5Ox (3% mol.)/MgO catalyst for total oxidation of methane?
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• 5. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
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