Production Method 1

141602-27-9

951884-36-9

Reaction Conditions

1.1 Reagents: Tosylhydrazine Solvents: Methyl chloride ;  rt → 90 °C; 16 h, 90 °C
1.2 Reagents: Sodium carbonate Solvents: Water ;  2 h, 90 °C

Reference

Preparation of triazolopyridine compounds useful in the treatment of diseases or disorders mediated by EED and/or PRC2

, World Intellectual Property Organization, , ,

Production Method 2

2244032-23-1

951884-36-9

Reaction Conditions

1.1 Reagents: Sodium carbonate Solvents: Water ;  reflux; 2 h, reflux

Reference

Pharmaceutical intermediate (4-(1,1-difluoroethyl)pyrimidin-5-yl)methanamine hydrochloride and preparation method thereof

, China, , ,

Production Method 3

4595-59-9

951884-36-9

Reaction Conditions

1.1 Reagents: Magnesium ,  Iodine Solvents: 2-Methyltetrahydrofuran ;  rt; 0 °C
1.2 Solvents: 2-Methyltetrahydrofuran ;  0 °C; 0 °C → rt; 0.5 - 1 h, rt
1.3 Reagents: Acetic acid
1.4 Reagents: Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Water ;  8 - 12 h, 0 °C
1.5 Reagents: Hydrochloric acid Solvents: Water

Reference

A process for preparing 4-substituted-5-bromopyrimidines

, China, , ,

5-Bromo-4-ethylpyrimidine Raw materials

• 5-Bromopyrimidine
• 4-Methylbenzenesulfonic acid 2-(5-bromo-6-ethyl-4-pyrimidinyl)hydrazide
• 5-bromo-4-chloro-6-ethylpyrimidine

5-Bromo-4-ethylpyrimidine Preparation Products

• 5-Bromo-4-ethylpyrimidine (951884-36-9)

• 1. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
  Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
• 2. An Assessment of the Laminar Hypersonic Double-Cone Experiments in the LENS-XX Tunnel
  JaideepRay,PatrickBlonigan,EricT.Phipps,KathrynMaupin
• 3. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 4. An atomistic mechanism for the degradation of perovskite solar cells by trapped charge?
  Eunhak Lim,Jiyoung Heo,Seong Keun Kim Nanoscale, 2019,11, 11369-11378
• 5. An ion-gating multinanochannel system based on a copper-responsive self-cleaving DNAzyme?
  Yang Chen,Di Zhou,Zheyi Meng,Jin Zhai Chem. Commun., 2016,52, 10020-10023

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Halopyrimidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Halopyrimidines

• 951884-30-3(5-bromo-4-sec-butylpyrimidine)
• 4595-64-6(5-Bromo-4-butylpyrimidine)
• 1033201-80-7(5-Bromo-4-octylpyrimidine)
• 951884-34-7(5-Bromo-4-pentylpyrimidine)
• 951884-24-5(5-Bromo-4-isooctylpyrimidine)
• 951884-44-9(5-Bromo-4-heptylpyrimidine)
• 951884-26-7(5-bromo-4-propylpyrimidine)
• 951884-42-7(5-Bromo-4-isopentylpyrimidine)
• 951884-28-9(5-bromo-4-isopropylpyrimidine)
• 951884-38-1(5-Bromo-4-hexylpyrimidine)