Production Method 1

6638-79-5

95092-10-7

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Tetrahydrofuran ,  Water ;  pH 4.5, rt
1.2 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride Solvents: Water ;  0.5 h, pH 4.5, rt; 3 h, rt

Reference

Preparation of peptides for treating tumors

, United States, , ,

Production Method 2

6638-79-5

95092-10-7

Reaction Conditions

1.1 Solvents: Dichloromethane ;  rt → 0 °C
1.2 Reagents: Pyridine ;  5 min, 0 °C; 10 min, 0 °C; 0 °C → rt; 1 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ;  rt

Reference

Sequential C-selective difluoromethylation/Pd-catalyzed decarboxylative protonation: an efficient access to tertiary difluoromethylated Scaffolds

Duchemin, Nicolas; Buccafusca, Roberto; Daumas, Marc; Ferey, Vincent; Arseniyadis, Stellios, ChemRxiv, 2019, 1, 1-8

Production Method 3

1117-97-1

95092-10-7

Reaction Conditions

1.1 Solvents: Water ;  12 h, pH 6, 30 °C
1.2 0.5 h, rt

Reference

Preparation of fosamprenavir intermediate (2R,3S)-1,2-epoxy-3-tert-butoxycarbonylamino-4-phenylbutane

, China, , ,

Production Method 4

1117-97-1

95092-10-7

Reaction Conditions

1.1 Reagents: Pyridine Solvents: Dichloromethane ;  5 min, 0 °C; 5 min, 0 °C; 1 h, rt

Reference

Highly Stereoselective Cyclopropanation of α,β-Unsaturated Carbonyl Compounds with Methyl (Diazoacetoxy)acetate Catalyzed by a Chiral Ruthenium(II) Complex

Chanthamath, Soda; Takaki, Suguru; Shibatomi, Kazutaka; Iwasa, Seiji, Angewandte Chemie, 2013, 52(22), 5818-5821

Production Method 5

1117-97-1

95092-10-7

Reaction Conditions

1.1 Reagents: Pyridine Solvents: Dichloromethane

Reference

Stereoselective synthesis of substituted N-heterocycles via sequential cross metathesis-reductive cyclization

Gebauer, Julian; Dewi, Purnama; Blechert, Siegfried, Tetrahedron Letters, 2005, 46(1), 43-46

Production Method 6

1117-97-1

95092-10-7

Reaction Conditions

1.1 Reagents: Triethylamine ,  Diethyl dicarbonate Solvents: Dimethylformamide ;  30 min, -10 °C; 2.5 h, rt

Reference

Composition for the treatment of IGF-1R expressing cancer

, World Intellectual Property Organization, , ,

Production Method 7

6638-79-5

95092-10-7

Reaction Conditions

1.1 Reagents: Triethylamine ,  Diethyl cyanophosphonate Solvents: Dimethylformamide ;  30 min, -10 °C; 2.5 h, rt

Reference

Preparation of monomethyl auristatin F derivatives and their trastuzumab conjugates for treating cancers

, World Intellectual Property Organization, , ,

Production Method 8

6638-79-5

95092-10-7

Reaction Conditions

1.1 Reagents: Triethylamine ,  Diethyl cyanophosphonate Solvents: Dimethylformamide ;  30 min, -10 °C; 2.5 h, rt

Reference

Preparation of humanized anti-human IGF-1R antibody-drug conjugates for cancer therapy

, World Intellectual Property Organization, , ,

Production Method 9

6638-79-5

95092-10-7

Reaction Conditions

1.1 Reagents: Triethylamine ,  Diethyl cyanophosphonate Solvents: Dimethylformamide ;  30 min, -10 °C; 2.5 h, rt

Reference

Preparation of derivatives of dolastatin 10 and auristatins as antitumor agents

, France, , ,

Production Method 10

6638-79-5

95092-10-7

Reaction Conditions

1.1 Reagents: Pyridine Solvents: Dichloromethane ;  0 °C; 4 h, rt

Reference

Structure-Based Drug Design of Mineralocorticoid Receptor Antagonists to Explore Oxosteroid Receptor Selectivity

Nordqvist, Anneli ; O'Mahony, Gavin; Friden-Saxin, Maria; Fredenwall, Marlene; Hogner, Anders; et al, ChemMedChem, 2017, 12(1), 50-65

Production Method 11

6638-79-5

95092-10-7

Reaction Conditions

1.1 Reagents: Pyridine Solvents: Dichloromethane ;  0 °C; overnight, rt

Reference

Assemblies of 1,4-Bis(diarylamino)naphthalenes and Aromatic Amphiphiles: Highly Reducing Photoredox Catalysis in Water

Hyodo, Yuki; Takahashi, Keigo; Chitose, Youhei; Abe, Manabu ; Yoshizawa, Michito; et al, Synlett, 2022, 33(12), 1184-1188

Production Method 12

1117-97-1

95092-10-7

Reaction Conditions

1.1 Reagents: Pyridine Solvents: Dichloromethane ;  5 min, 0 °C; 10 min, 0 °C; 0 °C → rt; 1 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water

Reference

A Unified Strategy for the Synthesis of Difluoromethyl- and Vinylfluoride-Containing Scaffolds

Duchemin, Nicolas; Buccafusca, Roberto; Daumas, Marc; Ferey, Vincent; Arseniyadis, Stellios, Organic Letters, 2019, 21(20), 8205-8210

Production Method 13

1117-97-1

95092-10-7

Reaction Conditions

1.1 Reagents: Pyridine Solvents: Dichloromethane ;  0 °C; 2 h, 0 °C; 0 °C → rt

Reference

Enantioselective synthesis of hydantoins by chiral acid-catalysed condensation of glyoxals and ureas

Aryal, Sushant; Hone, Christopher A.; Polson, Matthew I. J.; Foley, Daniel J., Chemical Science, 2023, 14(29), 7905-7912

Production Method 14

6638-79-5

95092-10-7

Reaction Conditions

1.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Tetrahydrofuran ;  1 h, rt
1.2 Reagents: Trimethylamine Solvents: Acetonitrile ;  1 h, rt
1.3 20 h, rt

Reference

Stereoselective synthesis of 2-aryl-4-en-1-ols, promising synthons for the preparation of oxygen heterocycles

Boev, V. I.; Moskalenko, A. I.; Belopukhov, S. L.; Nikonova, G. N., Russian Journal of Organic Chemistry, 2017, 53(2), 169-177

Production Method 15

6638-79-5

95092-10-7

Reaction Conditions

1.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Dichloromethane ;  rt; 1 h, rt
1.2 overnight, rt

Reference

3-Alkoxy-1,2-Dioxolanes: Synthesis and Evaluation as Potential Antimalarial Agents

Schiaffo, Charles E.; Rottman, Matthias; Wittlin, Sergio; Dussault, Patrick H., ACS Medicinal Chemistry Letters, 2011, 2(4), 316-319

Production Method 16

6638-79-5

95092-10-7

Reaction Conditions

1.1 Reagents: Diisopropylethylamine ,  O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate Solvents: Dichloromethane ;  6 h, rt

Reference

Preparation method of organic arsenic-based type II pyruvate kinase inhibitor, and its application in inhibiting tumor

, China, , ,

Production Method 17

6638-79-5

95092-10-7

Reaction Conditions

1.1 Reagents: Triethylamine ,  Diethyl cyanophosphonate Solvents: Dimethylformamide ;  30 min, -10 °C; 2.5 h, rt

Reference

Preparation of humanized anti-human IGF-1R, HER2 and protein Axl antibodies conjugated with drug for treatment of cancer

, World Intellectual Property Organization, , ,

Production Method 18

6638-79-5

95092-10-7

Reaction Conditions

1.1 Reagents: Pyridine Solvents: Dichloromethane ;  30 min, 0 °C; 30 min, rt

Reference

Asymmetric photoredox transition-metal catalysis activated by visible light

Huo, Haohua; Shen, Xiaodong; Wang, Chuanyong; Zhang, Lilu; Roese, Philipp; et al, Nature (London, 2014, 515(7525), 100-103

N-Methoxy-N-methyl-2-phenylacetamide Raw materials

• N,O-Dimethylhydroxylamine
• N,O-Dimethylhydroxylamine hydrochloride

N-Methoxy-N-methyl-2-phenylacetamide Preparation Products

• N-Methoxy-N-methyl-2-phenylacetamide (95092-10-7)

• 1. Aggregation of biologically important peptides and proteins: inhibition or acceleration depending on protein and metal ion concentrations
  Benjamin Gabriel Poulson,Kacper Szczepski,Joanna Izabela Lachowicz,Lukasz Jaremko,Abdul-Hamid Emwas,Mariusz Jaremko RSC Adv., 2020,10, 215-227
• 2. An investigation into the origin of variations in photovoltaic performance using D–D–π–A and D–A–π–A triphenylimidazole dyes with a copper electrolyte?
  Govind Reddy Mol. Syst. Des. Eng., 2021,6, 779-789
• 3. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
• 4. An approach for correlating the structural and electrical properties of Zr4+-modified SrBi4Ti4O15/SBT ceramic
  Priyambada Nayak,Tanmaya Badapanda,Anil Kumar Singh,Simanchalo Panigrahi RSC Adv., 2017,7, 16319-16331
• 5. An analysis of the WTC fires using CIB correlations and simple modeling
  JGQuintiere

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylacetamides

• 1265905-03-0
• 267884-97-9(N-methoxy-N-methyl-2-(m-tolyl)acetamide)
• 170646-96-5(N-methoxy-N-methyl-3-phenylpropanamide)
• 149652-50-6(2-(4-bromophenyl)-N-methoxy-N-methylacetamide)
• 72229-75-5(Benzeneacetamide,N-hydroxy-N-methyl-)
• 457948-95-7(2-(4-Fluorophenyl)-N-methoxy-N-methylacetamide)
• 841234-77-3(Benzeneacetamide, N-methoxy-N-methyl-3-(phenylethynyl)-)
• 918417-27-3(N-methoxy-N-methyl-2-(o-tolyl)acetamide)
• 93008-38-9(N-METHOXY-N-METHYL-2,2-DIPHENYL-ACETAMIDE)
• 841234-82-0(Benzeneacetamide, N-methoxy-N-methyl-4-(phenylethynyl)-)