Production Method 1

143805-46-3

94956-98-6

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Water

Reference

Synthesis of 2-substituted-3-methoxybenzaldehydes by condensation of ortho-lithiated 2-(3-methoxyphenyl)-4,4-dimethyl-Δ2-oxazoline with appropriate electrophiles

Islam, M. Rabiul; Joule, John A., Journal of the Bangladesh Chemical Society, 1992, 5(1), 15-22

Production Method 2

2715082-39-4

94956-98-6

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  -78 °C; 30 min, -78 °C
1.2 Reagents: Copper bromide (CuBr) ;  -78 °C; 5 h, -78 °C
1.3 -78 °C; overnight, -78 °C → rt
1.4 Reagents: Hydrochloric acid Solvents: Water ;  3 h

Reference

Nickel-Catalyzed Intramolecular Hydroalkenylation of Imines

Feng, Wei-Min; Li, Tian-Yu; Xiao, Li-Jun ; Zhou, Qi-Lin, Organic Letters, 2021, 23(20), 7900-7904

Production Method 3

100-83-4

94956-98-6

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ;  10 min, 25 °C
1.2 25 °C; 8 h, reflux; reflux → 25 °C
1.3 Solvents: Decalin ;  8 h, reflux; reflux → 25 °C
1.4 Reagents: Potassium carbonate Solvents: Tetrahydrofuran ;  10 min, 25 °C
1.5 8 h, reflux

Reference

PdCl2/CuCl2/Bi(OTf)3-promoted Construction of Sulfonyl Dibenzooxabicyclo[3.3.1]nonanes and Arylnaphthalenes via Intramolecular Annulation of Sulfonyl o-Allylarylchromanones

Hsueh, Nai-Chen; Chang, Meng-Yang, Advanced Synthesis & Catalysis, 2020, 362(24), 5736-5750

Production Method 4

79950-42-8

94956-98-6

Reaction Conditions

Reference

Synthesis of Substituted 2,3-Benzodiazepines

Chan, Chieh-Kai; Tsai, Yu-Lin; Chan, Yi-Ling; Chang, Meng-Yang, Journal of Organic Chemistry, 2016, 81(20), 9836-9847

Production Method 5

79950-42-8

94956-98-6

Reaction Conditions

1.1 Reagents: Sodium hydride

Reference

Total synthesis of quinocarcinol methyl ester

Danishefsky, Samuel J.; Harrison, Peter J.; Webb, Robert R. II; O'Neill, Brian T., Journal of the American Chemical Society, 1985, 107(5), 1421-3

Production Method 6

79950-42-8

94956-98-6

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetone ;  8 h, reflux; reflux → rt
1.2 Solvents: Water ;  8 h, rt

Reference

Synthesis of 3-Azidopiperidine Skeleton Employing Ceric Ammonium Nitrate (CAN)-Mediated Regioselective Azidoalkoxylation of Enol Ether: Total Synthesis of D2 Receptor Agonist (±)-Quinagolide

Chavan, Subhash P. ; Kadam, Appasaheb L.; Lasonkar, Pradeep B.; Gonnade, Rajesh G., Organic Letters, 2018, 20(22), 7011-7014

Production Method 7

79950-42-8

94956-98-6

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Ethanol ;  10 min, rt
1.2 6 h, reflux

Reference

Synthesis of Polysubstituted 3-Methylisoquinolines through the π-Electron Cyclization/Elimination of 1-Azatrienes derived from 1,1-Dimethylhydrazine

Vargas, Didier F.; Larghi, Enrique L. ; Kaufman, Teodoro S., European Journal of Organic Chemistry, 2018, 2018(40), 5605-5614

Production Method 8

136911-16-5

94956-98-6

Reaction Conditions

1.1 Reagents: Dimethyl sulfoxide ,  Oxalyl chloride Solvents: Dichloromethane ;  30 min, -78 °C
1.2 Solvents: Dichloromethane ;  1 h, -78 °C
1.3 Reagents: Triethylamine ;  overnight, -78 °C → rt

Reference

The Intramolecular Asymmetric Pauson-Khand Cyclization as a Novel and General Stereoselective Route to Benzindene Prostacyclins: Synthesis of UT-15 (Treprostinil)

Moriarty, Robert M.; Rani, Neena; Enache, Livia A.; Rao, Munagala S.; Batra, Hitesh; et al, Journal of Organic Chemistry, 2004, 69(6), 1890-1902

Production Method 9

100-83-4

94956-98-6

Reaction Conditions

1.1 Reagents: Dichlorophenylborane ,  Lithium diisopropylamide
1.2 -

Reference

Synthesis of dihydrobenzoimidazo[2,1-a]isoquinolines

Chang, Meng-Yang; Wu, Ming-Hao; Chen, Yeh-Long, Tetrahedron Letters, 2012, 53(32), 4156-4160

Production Method 10

100-83-4

94956-98-6

1378359-97-7

Reaction Conditions

1.1 Reagents: Potassium carbonate
1.2 Solvents: Decalin ;  reflux
1.3 Reagents: Potassium carbonate

Reference

Facile synthesis of substituted isoquinolines

Chang, Meng-Yang; Wu, Ming-Hao; Lee, Nein-Chia; Lee, Ming-Fang, Tetrahedron Letters, 2012, 53(16), 2125-2128

Production Method 11

100-83-4

94956-98-6

Reaction Conditions

1.1 Reagents: Potassium carbonate
1.2 Reagents: Decalin ;  heated
1.3 Reagents: Potassium carbonate Solvents: Acetone

Reference

CuI Mediated One-Pot Cycloacetalization/Ketalization of o-Carbonyl Allylbenzenes: Synthesis of Benzobicyclo[3.2.1]octane Core

Chan, Chieh-Kai; Tsai, Yu-Lin; Chang, Meng-Yang, Organic Letters, 2017, 19(7), 1870-1873

Production Method 12

88440-85-1

94956-98-6

Reaction Conditions

1.1 Reagents: Butyllithium ,  Diisobutylaluminum hydride Solvents: Tetrahydrofuran ,  Hexane ;  0.5 h, 0 °C
1.2 Solvents: Tetrahydrofuran ;  1 h, 0 °C; 20 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Water

Reference

Ambiphilic Vinylcarbenoid Reactivity of (α-(Tributylstannyl)-π-allyl)palladium(II) Species

Trepanier, Vincent E.; Fillion, Eric, Organometallics, 2007, 26(1), 30-32

Production Method 13

79950-42-8

94956-98-6

Reaction Conditions

1.1 Reagents: Potassium carbonate

Reference

tBuO2H/Cu(acac)2-Mediated Intramolecular Oxidative Lactonization of o-Allyl Arylaldehydes: Synthesis of 1-Oxoisochromans

Chang, Meng-Yang ; Lai, Kai-Xiang; Chen, Kuan-Ting, Synthesis, 2021, 53(3), 527-537

Benzaldehyde, 3-methoxy-2-(2-propenyl)- Raw materials

• 3-Hydroxybenzaldehyde
• Benzene, 2-bromo-1-(dimethoxymethyl)-3-methoxy-
• Benzamide, N,N-diethyl-3-methoxy-2-(2-propenyl)-
• Oxazolidine, 2-[3-methoxy-2-(2-propenyl)phenyl]-3,4,4-trimethyl-
• (2-Allyl-3-methoxyphenyl)methanol
• 3-hydroxy-2-(prop-2-en-1-yl)benzaldehyde

Benzaldehyde, 3-methoxy-2-(2-propenyl)- Preparation Products

• Benzaldehyde, 3-methoxy-2-(2-propenyl)- (94956-98-6)
• 4-Allyl-3-methoxybenzaldehyde (1378359-97-7)

• 1. An artificial photosynthetic system for photoaccumulation of two electrons on a fused dipyridophenazine (dppz)–pyridoquinolinone ligand?
  Philipp Traber,Stephan Kupfer,Stefanie Gr?fe,Isabelle Baussanne,Martine Demeunynck,Jean-Marie Mouesca,Serge Gambarelli,Vincent Artero,Murielle Chavarot-Kerlidou Chem. Sci., 2018,9, 4152-4159
• 2. Alternative donor substrates for inverting and retaining glycosyltransferases?
  Luke L. Lairson,Warren W. Wakarchuk Chem. Commun., 2007, 365-367
• 3. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
• 4. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 5. An aptasensor for the detection of ampicillin in milk using a personal glucose meter
  Xixi Li,Nanwei Zhu,Ruohan Li,Qinpu Zhang Anal. Methods, 2020,12, 3376-3381

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoyl derivatives

Exploring Benzaldehyde, 3-methoxy-2-(2-propenyl)- (CAS No. 94956-98-6): Properties, Applications, and Industry Trends

Benzaldehyde, 3-methoxy-2-(2-propenyl)- (CAS No. 94956-98-6) is a specialized aromatic compound with a unique molecular structure combining a benzaldehyde core, a methoxy group, and an allyl side chain. This configuration grants it distinct chemical properties, making it valuable in fragrance synthesis, flavor enhancement, and pharmaceutical intermediates. As demand for sustainable and bio-based ingredients grows, researchers are increasingly exploring its potential in green chemistry applications.

The compound’s 3-methoxy-2-(2-propenyl) substitution pattern contributes to its olfactory characteristics, often described as warm, spicy, and slightly floral. Perfumers leverage these notes to create complex accords in premium fragrances, aligning with the rising consumer preference for natural-inspired scents. In the food industry, it serves as a flavor modifier at controlled concentrations, addressing the global trend toward clean-label products.

From a synthetic perspective, Benzaldehyde, 3-methoxy-2-(2-propenyl)- exemplifies innovations in selective allylation and methoxylation techniques. Recent studies highlight its role in catalytic asymmetric reactions, a hotspot in organic chemistry research. These advancements respond to the pharmaceutical sector’s need for chiral building blocks—a frequent search topic among chemists exploring CAS No. 94956-98-6 derivatives.

Analytical challenges associated with this compound, such as isomer separation and stability under UV exposure, are actively discussed in chromatography forums. Modern HPLC-MS methods now enable precise quantification, addressing quality control concerns raised by manufacturers. Such technical dialogues dominate professional platforms, reflecting the compound’s industrial relevance.

Environmental considerations are reshaping its applications. With tightening regulations on volatile organic compounds (VOCs), formulators seek encapsulated versions of 3-methoxy-2-(2-propenyl)-benzaldehyde to reduce emissions. This aligns with Google Trends data showing increased searches for "low-VOC fragrance ingredients" and "biodegradable aroma chemicals."

Supply chain dynamics further influence its market presence. As a benzaldehyde derivative, its pricing fluctuates with raw material availability, prompting formulators to explore alternative synthesis routes. Patent analyses reveal growing IP activity around microbial production methods—an eco-friendly approach gaining traction in ESG-focused industries.

In academic circles, the compound’s spectroscopic fingerprints (particularly in ¹³C NMR) serve as teaching examples for analyzing substituted aromatic systems. Educational content featuring CAS No. 94956-98-6 spectral data receives consistent engagement on chemistry e-learning platforms, underscoring its didactic value.

Looking ahead, cross-disciplinary applications are emerging. Materials scientists investigate its incorporation into polymer matrices for controlled-release systems, while agrochemical researchers study its potential as a plant growth modulator. These diverse use cases position Benzaldehyde, 3-methoxy-2-(2-propenyl)- as a compound of enduring scientific interest.

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• 16273-13-5(Phenol,6-methoxy-3-methyl-2-(2-propen-1-yl)-)
• 81418-45-3(Ethanone, 1-[1,4-dimethoxy-3-(2-propenyl)-2-naphthalenyl]-)
• 834867-31-1(2-Naphthalenecarboxaldehyde, 4,5,8-trimethoxy-3-(1-methyl-2-propen-1-yl)-)
• 85313-89-9(9,10-Anthracenedione, 1,8-dimethoxy-2-(2-propenyl)-)
• 79950-14-4(2-Allyl-3-hydroxybenzaldehyde)
• 374073-49-1(Benzaldehyde,3-ethoxy-4-methoxy-2-(2-propen-1-yl)-)
• 67483-48-1(3-Allyl-4-methoxybenzaldehyde)
• 79950-42-8(3-hydroxy-2-(prop-2-en-1-yl)benzaldehyde)
• 85313-88-8(9,10-Anthracenedione, 1-hydroxy-8-methoxy-2-(2-propenyl)-)