Production Method 1

201297-38-3

949-90-6

Reaction Conditions

1.1 Reagents: Dimethylamine Solvents: Methanol

Reference

Synthesis and characterization of B-O-Tosyldehydroserine as a precursor of dehydroamino acids

Nakazawa, Takashi; Susuki, Tomiko; Ishii, Masako, Tetrahedron Letters, 1997, 38(52), 8951-8954

Production Method 2

598-41-4

949-90-6

Reaction Conditions

1.1 Reagents: Potassium bicarbonate Solvents: 1,4-Dioxane ,  Water

Reference

Total synthesis of nosiheptide. Synthesis of thiazole fragments

Koerber-Ple, Karen; Massiot, Georges, Journal of Heterocyclic Chemistry, 1995, 32(4), 1309-15

Production Method 3

598-41-4

949-90-6

Reaction Conditions

1.1 Solvents: 1,4-Dioxane ,  Water ;  cooled; rt; 12 h, rt

Reference

Pyrimidine-4-carboxamide compounds useful as Raf kinase inhibitors and their preparation and use in the treatment of Raf-mediated diseases

, World Intellectual Property Organization, , ,

Production Method 4

598-41-4

949-90-6

Reaction Conditions

1.1 Solvents: 1,4-Dioxane ,  Water ;  cooled; rt; 12 h, rt

Reference

Heterocyclic compounds useful as Raf kinase inhibitors and their preparation, and use in the treatment of Raf-mediated diseases

, United States, , ,

Production Method 5

1138-80-3

949-90-6

Reaction Conditions

1.1 Reagents: Pyridine ,  Ammonium bicarbonate ,  Di-tert-butyl dicarbonate Solvents: Dimethylformamide

Reference

Activation of carboxylic acids by pyrocarbonates. Application of di-tert-butyl pyrocarbonate as condensing reagent in the synthesis of amides of protected amino acids and peptides

Pozdnev, Vladimir F., Tetrahedron Letters, 1995, 36(39), 7115-18

Production Method 6

1738-86-9

949-90-6

Reaction Conditions

1.1 Reagents: Ammonia Solvents: Methanol

Reference

Synthesis of arginine-containing peptides through their omithine analogs. Synthesis of arginine vasopressin, arginine vasotocin, and L-histidyl-L-phenylalanyl-L-arginyl-L-tryptoph-ylglycine

Bodanszky, Miklos; Ondetti, Miguel A.; Birkhimer, Carolyn A.; Thomas, Patsy L., Journal of the American Chemical Society, 1964, 86(20), 4452-9

Production Method 7

1138-80-3

949-90-6

Reaction Conditions

1.1 Reagents: Ammonium benzoate Catalysts: Triacylglycerol lipase Solvents: Toluene ;  16 h, 50 °C

Reference

Enzymatic C-terminal amidation of amino acids and peptides

Nuijens, Timo; Piva, Elena; Kruijtzer, John A. W.; Rijkers, Dirk T. S.; Liskamp, Rob M. J.; et al, Tetrahedron Letters, 2012, 53(29), 3777-3779

Production Method 8

1212-53-9

949-90-6

Reaction Conditions

1.1 Reagents: Ammonium hydroxide Solvents: Water

Reference

Inverse electron demand Diels-Alder reactions of indole. IV. A new route to β-carbolines

Fan, Wen-Hong; Parikh, Mamta; Snyder, John K., Tetrahedron Letters, 1995, 36(37), 6591-4

Production Method 9

3589-41-1

949-90-6

Reaction Conditions

1.1 Reagents: Water Catalysts: Ruthenium (supported on chitin) ,  Chitosan ;  16 h, 120 °C

Reference

Hydration of nitriles to amides by a chitin-supported ruthenium catalyst

Matsuoka, Aki; Isogawa, Takahiro; Morioka, Yuna; Knappett, Benjamin R.; Wheatley, Andrew E. H.; et al, RSC Advances, 2015, 5(16), 12152-12160

Production Method 10

1138-80-3

949-90-6

Reaction Conditions

1.1 Reagents: 4-Methylmorpholine ,  Isobutyl chloroformate Solvents: Tetrahydrofuran ;  2 min, -20 °C; 15 min, 0 °C
1.2 Reagents: Ammonia Solvents: Water ;  1 h, 0 °C

Reference

Polythiazole linkers as functional rigid connectors: a new RGD cyclopeptide with enhanced integrin selectivity

Ruiz-Rodriguez, J.; Miguel, M.; Preciado, S.; Acosta, G. A.; Adan, J.; et al, Chemical Science, 2014, 5(10), 3929-3935

Production Method 11

1138-80-3

949-90-6

Reaction Conditions

1.1 Reagents: 4-Methylmorpholine ,  Isobutyl chloroformate ,  Ammonia Solvents: Water

Reference

Preparation of cyclic RGD peptides of amino acids based on thiazoles or oxazoles as selective antagonists of αvβ3 integrin

, World Intellectual Property Organization, , ,

Production Method 12

1138-80-3

949-90-6

Reaction Conditions

1.1 Reagents: Methyl iodide ,  Sodium carbonate Solvents: Dimethylformamide ;  rt; 24 h, rt
1.2 Reagents: Ammonium hydroxide Solvents: Tetrahydrofuran ;  24 h, rt

Reference

Parallel Synthesis of An Oligomeric Imidazole-4,5-dicarboxamide Library

Xu, Zhigang; DiCesare, John C.; Baures, Paul W., Journal of Combinatorial Chemistry, 2010, 12(2), 248-254

Production Method 13

1138-80-3

949-90-6

Reaction Conditions

1.1 Reagents: Dicyclohexylcarbodiimide ,  1-Hydroxybenzotriazole Solvents: Dimethylformamide ,  Dichloromethane
1.2 Reagents: Ammonia Solvents: Dimethylformamide ,  Dichloromethane ,  Water

Reference

A simple method for amide formation from protected amino acids and peptides

Chen, Shui Tein; Wu, Shih Hsiung; Wang, Kung Tsung, Synthesis, 1989, (1), 37-8

Production Method 14

1138-80-3

949-90-6

Reaction Conditions

1.1 Reagents: Triethylamine ,  Ethyl chloroformate Solvents: Tetrahydrofuran ;  -10 °C; 30 min, -10 °C
1.2 Reagents: Ammonia Solvents: Water ;  45 min, -10 °C

Reference

N-Alkenylation of hydroxamic acid derivatives with ethynyl benziodoxolone to synthesize cis-enamides through vinyl benziodoxolones

Shimbo, Daisuke; Maruyama, Toshifumi; Tada, Norihiro; Itoh, Akichika, Organic & Biomolecular Chemistry, 2021, 19(11), 2442-2447

Production Method 15

1138-80-3

949-90-6

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Tetrahydrofuran ;  5 min, 0 °C
1.2 Reagents: Ethyl chloroformate ;  15 min, 0 °C
1.3 Reagents: Ammonia ;  1 h, rt

Reference

Urea derivatives as pyruvate kinase activators and their preparation

, World Intellectual Property Organization, , ,

Production Method 16

1668-10-6

949-90-6

Reaction Conditions

1.1 Reagents: Sodium carbonate Solvents: Acetone ,  Water ;  pH 8, 0 °C
1.2 0 °C; 2 h, rt

Reference

Antibody drug conjugate containing SN38 and its application in cancer and autoimmune disease

, China, , ,

Production Method 17

1138-80-3

949-90-6

Reaction Conditions

1.1 Reagents: Triethylamine ,  Ethyl chloroformate
1.2 Reagents: Ammonia Solvents: Water

Reference

Convenient synthesis of phosphonodipeptides containing C-terminal α-aminoalkylphosphonic acids

Sun, Biyun; Xu, Jiaxi, Journal of Peptide Science, 2015, 21(7), 615-619

Production Method 18

1138-80-3

949-90-6

Reaction Conditions

1.1 Reagents: 4-Methylmorpholine ,  Ethyl chloroformate Solvents: Tetrahydrofuran ;  20 min, -15 °C
1.2 Reagents: Ammonia Solvents: Water ;  4 h, -15 °C

Reference

One-pot synthesis of orthogonally protected dipeptide selenazoles employing Nα-amino selenocarboxamides and α-bromomethyl ketones

Madhu, Chilakapati; Panguluri, Nageswara Rao; Narendra, N.; Panduranga, V.; Sureshbabu, Vommina V., Tetrahedron Letters, 2014, 55(50), 6831-6835

Production Method 19

1138-80-3

949-90-6

Reaction Conditions

1.1 Reagents: Triethylamine ,  Ethyl chloroformate Solvents: Tetrahydrofuran ;  0 °C; 30 min, 0 °C
1.2 Reagents: Ammonia ;  30 min, 0 °C

Reference

Direct synthesis of phosphinopeptides containing C-terminal α-aminoalkylphosphinic acids

Meng, Fan-Hua; Xu, Jia-Xi, Amino Acids, 2010, 39(2), 533-538

Production Method 20

3899-07-8

1138-80-3

949-90-6

Reaction Conditions

1.1 Reagents: Dicyclohexylcarbodiimide ,  N-Hydroxysuccinimide Solvents: Acetonitrile
1.2 Solvents: Acetonitrile

Reference

Structure-activity relationships of dopaminergic 5-hydroxy-2-aminotetralin derivatives with functionalized N-alkyl substituents

Seiler, Max P.; Stoll, Andre P.; Closse, Annemarie; Frick, Willy; Jaton, Annelise; et al, Journal of Medicinal Chemistry, 1986, 29(6), 912-17

Z-Gly-nh2 Raw materials

• Glycinamide hydrochloride
• 4-Nitrophenyl ((benzyloxy)carbonyl)glycinate
• Benzyl Cyanomethylcarbamate
• Z-Gly-ome
• (5-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YL)-PROPYL-AMINE HYDROCHLORIDE
• Z-Glycine
• 2-Aminoacetamide
• Carbamic acid, [1-(aminocarbonyl)-2-[[(4-methylphenyl)sulfonyl]oxy]ethenyl]-, phenylmethyl ester

Z-Gly-nh2 Preparation Products

• Z-Gly-nh2 (949-90-6)

• 1. An integrated chip for immunofluorescence and its application to analyze lysosomal storage disorders
  Jie Shen,Ying Zhou,Tu Lu,Junya Peng,Zhixiang Lin,Yuhong Pang,Li Yu Lab Chip, 2012,12, 317-324
• 2. Alt-proteins: A promising future
• 3. An atomistic mechanism for the degradation of perovskite solar cells by trapped charge?
  Eunhak Lim,Jiyoung Heo,Seong Keun Kim Nanoscale, 2019,11, 11369-11378
• 4. Aluminium complexes with thio-phosphorus ligands: syntheses and characterisations of [Al2(CyPS3)2(CyPHS2)2] and [Al(S2PPh2)3]?
  Robert P. Davies,Maria A. Giménez,Laura Patel,Andrew J. P. White Dalton Trans., 2008, 5705-5707
• 5. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzyloxycarbonyls
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

• 7598-84-7(Z-Gly-Gly-Gly-Gly-Gly-Gly-OH)
• 2619-82-1(Glycinamide,N-[(phenylmethoxy)carbonyl]glycylglycyl- (9CI))
• 5680-83-1(N-Cbz-glycine hydrazide)
• 6422-35-1(Z-GLY-GLY-NH2)
• 67561-03-9(benzyl 2-oxoethylcarbamate)
• 20228-72-2(Z-Gly-Gly-Gly-Gly-Gly-OH)
• 2566-19-0(2-(2-(((Benzyloxy)carbonyl)amino)acetamido)acetic acid)
• 2566-20-3(Z-Gly-gly-gly-oh)
• 78818-15-2(Benzyl 3-oxopiperazine-1-carboxylate)
• 72080-83-2(Benzyl 2-Aminoethylcarbamate)