Production Method 1

1019546-41-8

94805-52-4

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Toluene ,  Water ;  2 h, rt

Reference

Preparation of Azinones from (Cyclopropylmethoxy)azine Ethers

Londregan, Allyn T. ; Curto, John M.; Hastry, Emma; Rose, Colin R.; Berritt, Simon, Journal of Organic Chemistry, 2023, 88(9), 5671-5675

Production Method 2

4214-73-7

94805-52-4

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Sulfuric acid Solvents: Water ;  0 - 5 °C; 30 min, 100 °C; 100 °C → rt; 1 h, rt

Reference

Preparation of (aza)indazolyl-aryl sulfonamide and related compounds for inhibiting GCN2 activity

, World Intellectual Property Organization, , ,

Production Method 3

4214-73-7

94805-52-4

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Sulfuric acid Solvents: Water ;  0 - 5 °C; 5 °C → rt; 30 min, reflux

Reference

Preparation of oxadiazole-benzofuran derivatives having S1P1 receptor activity and/or disease modifying activity

, World Intellectual Property Organization, , ,

Production Method 4

15871-85-9

94805-52-4

Reaction Conditions

1.1 Reagents: Sodium ethanethiolate Solvents: Dimethylformamide ;  rt → 60 °C; 4 h, 60 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 6

Reference

Pyridine, pyrazine and azaindole compounds as stress activated protein kinase modulators and their preparation and use in the treatment of inflammatory and fibrotic disorders

, World Intellectual Property Organization, , ,

Production Method 5

3670-59-5

94805-52-4

Reaction Conditions

1.1 Reagents: Cyanuric chloride Solvents: Dimethylformamide ;  20 - 30 °C; 1 h, 20 - 30 °C
1.2 Reagents: Water ;  20 - 30 °C; 1 h, 20 - 30 °C

Reference

Method for preparing 3-cyano-6-hydroxypyridine from 6-hydroxynicotinic acid

, China, , ,

Production Method 6

690952-21-7

37181-39-8

94805-52-4

Reaction Conditions

1.1 Reagents: Cesium carbonate ,  Benzaldehyde oxime Solvents: Tetrahydrofuran ;  20 min, rt
1.2 rt → 80 °C; 4 h, 80 °C
1.3 Reagents: Hydrochloric acid Solvents: Methanol ;  pH 3

Reference

Synthesis of Phenols from Aryl Ammonium Salts under Mild Conditions

Ni, Pufan; Yang, Lei; Shen, Yi; Zhang, Lei; Ma, Yueyue; et al, Journal of Organic Chemistry, 2022, 87(19), 12677-12687

Production Method 7

4214-73-7

94805-52-4

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Sulfuric acid Solvents: Water ;  2 h, 0 °C

Reference

Synthesis of a series of iridium complexes bearing substituted 2-pyridonates and their catalytic performance for acceptorless dehydrogenation of alcohols under neutral conditions

Yamaguchi, Ryohei; Kobayashi, Daiki; Shimizu, Mineyuki; Fujita, Ken-ichi, Journal of Organometallic Chemistry, 2017, 843, 14-19

Production Method 8

100-54-9

94805-52-4

Reaction Conditions

1.1 Solvents: Water ;  32 h, pH 7.0, 30 °C

Reference

A combined process of hydroxylation of nicotinic acid by growing culture and hydroxylation of 3-cyanopyridine by resting cells of Comamonas testosteroni JA1

Yuan, S.; Yang, Y.; Sun, J.; Liang, M.-X.; Dai, Y.-J.; et al, Engineering in Life Sciences, 2005, 5(4), 369-374

Production Method 9

100-54-9

94805-52-4

Reaction Conditions

1.1 Catalysts: Hydroxylase Solvents: Water ;  24 h, pH 7.0, 28 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 3.0

Reference

Production process of hydroxylating nicotinic acid and cyanopyridine by using microorganism

, China, , ,

Production Method 10

100-54-9

94805-52-4

Reaction Conditions

Reference

Microbial hydroxylation of 3-cyanopyridine to 3-cyano-6-hydroxypyridine

Yasuda, Mari; Sakamoto, Takeshi; Sashida, Reiko; Ueda, Makoto; Morimoto, Yuuki; et al, Bioscience, 1995, 59(4), 572-5

Production Method 11

100-54-9

94805-52-4

Reaction Conditions

1.1 Catalysts: Delftia acidovorans

Reference

Preparation of pyridine derivatives as intermediates for pharmaceuticals, agrochemicals, and dyes

, Japan, , ,

Production Method 12

100-54-9

94805-52-4

Reaction Conditions

Reference

Preparation of 6-hydroxy pyridines or pyrazines by microbial hydroxylation

, European Patent Organization, , ,

6-oxo-1H-pyridine-3-carbonitrile Raw materials

• 6-Hydroxynicotinamide
• 5-Cyano-N,N,N-trimethyl-2-pyridinaminium
• 6-Methoxynicotinonitrile
• 6-aminopyridine-3-carbonitrile
• pyridine-3-carbonitrile
• 6-(cyclopropylmethoxy)pyridine-3-carbonitrile

6-oxo-1H-pyridine-3-carbonitrile Preparation Products

• 6-oxo-1H-pyridine-3-carbonitrile (94805-52-4)

• 1. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 2. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 3. Enantiomeric helical TiO2 nanofibers modulate different peptide assemblies and subsequent cellular behaviors?
  Xu Jie,Deng Xu,Weili Wei RSC Adv., 2019,9, 29149-29153
• 4. Evolutionary approaches in protein engineering towards biomaterial construction
  Brindha J.,Balamurali M. M.,Kaushik Chanda RSC Adv., 2019,9, 34720-34734
• 5. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849

• 106853-78-5(6-ethoxypyridine-3-carbonitrile)
• 91914-06-6(2-Hydroxy-5-methylpyridine)
• 1951441-17-0(2-Hydroxy-nicotinonitrile hydrobroMide)
• 15871-85-9(6-Methoxynicotinonitrile)
• 2645415-70-7(5-methylpyridin-3,4,6-d3-2-ol)
• 95891-30-8(6-Hydroxynicotinonitrile)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)