Production Method 1

676500-39-3

947279-29-0

Reaction Conditions

1.1 Reagents: Cesium carbonate Solvents: Dimethylformamide ;  3 d, rt
1.2 Reagents: Water

Reference

1,1-Dioxo-1-thia-5,10-diazadibenzocycloheptenes useful as hepatitis C virus inhibitors and their preparation and use in the treatment of hepatitis C infection

, World Intellectual Property Organization, , ,

Production Method 2

144292-53-5

947279-29-0

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ;  -68 °C; 2 h, < -60 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  < -60 °C; pH 6, < -60 °C → -40 °C

Reference

A study on the metalation of fluorinated phenyl benzyl ethers

Klis, Tomasz; Serwatowski, Janusz; Wojcik, Dominik, Applied Organometallic Chemistry, 2006, 20(10), 677-682

2,3-Difluoro-4-phenylmethoxybenzaldehyde Raw materials

• 2,3-Difluoro-4-hydroxybenzaldehyde
• 1,2-Difluoro-3-phenylmethoxybenzene

2,3-Difluoro-4-phenylmethoxybenzaldehyde Preparation Products

• 2,3-Difluoro-4-phenylmethoxybenzaldehyde (947279-29-0)

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• 103438-92-2(Benzaldehyde, 2-fluoro-5-(phenylmethoxy)-)
• 504414-32-8(4-(Benzyloxy)-2-fluorobenzaldehyde)
• 445421-41-0(BENZOIC ACID, 3,5-BIS[(PENTAFLUOROPHENYL)METHOXY]-)
• 850461-79-9(BENZALDEHYDE, 2-FLUORO-4-[(3-METHOXYPHENOXY)METHYL]-)
• 70627-20-2(4-[(2-fluorophenyl)methoxy]benzaldehyde)
• 136264-93-2(Benzoic acid, pentafluoro-, 4-methylphenyl ester)
• 114045-96-4(4-(Benzyloxy)-2-fluorobenzoic acid)
• 885269-73-8(4-[(2,6-difluorophenyl)methoxy]benzaldehyde)
• 636796-38-8(BENZOIC ACID, 2,6-DIFLUORO-4-[(3-FLUOROPHENYL)METHOXY]-)
• 423724-45-2(3-[(2-fluorophenyl)methoxy]benzaldehyde)