Production Method 1

1122090-59-8

947179-03-5

Reaction Conditions

1.1 Catalysts: Sulfuric acid Solvents: Ethanol ;  rt; rt → 70 °C; 4 h, 70 °C

Reference

Novel S1P1 Receptor Agonists - Part 3: From Thiophenes to Pyridines

Bolli, Martin H.; Abele, Stefan; Birker, Magdalena; Bravo, Roberto; Bur, Daniel; et al, Journal of Medicinal Chemistry, 2014, 57(1), 110-130

Production Method 2

1122090-59-8

947179-03-5

Reaction Conditions

1.1 Catalysts: Sulfuric acid Solvents: Ethanol ,  Water ;  rt; 16 h, rt → 70 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water

Reference

Preparation of phenyloxadiazolyl pyridines as immunomodulating agents

, World Intellectual Property Organization, , ,

Production Method 3

1122090-59-8

947179-03-5

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Ethanol ,  Water ;  16 h, rt → 70 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water

Reference

Preparation of dipyridinyl derivatives as therapeutic S1P1/EDG1 receptor modulators

, World Intellectual Property Organization, , ,

Production Method 4

886372-47-0

947179-03-5

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Water ;  8 h, reflux
1.2 Reagents: Sodium carbonate Solvents: Water ;  pH 7

Reference

Pyridine-2-carboxamide derivatives as metabotropic glutamate receptor antagonists and their preparation, pharmaceutical compositions and use in the treatment of diseases

, World Intellectual Property Organization, , ,

Ethyl 4-bromo-6-methyl-2-pyridinecarboxylate Raw materials

• Potassium 4-bromo-6-methylpicolinate
• 4-Bromo-6-methyl-pyridine-2-carboxylic Acid

Ethyl 4-bromo-6-methyl-2-pyridinecarboxylate Preparation Products

• Ethyl 4-bromo-6-methyl-2-pyridinecarboxylate (947179-03-5)

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  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526

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