Production Method 1

4885-02-3

456-55-3

94651-33-9

Reaction Conditions

1.1 Reagents: Aluminum chloride Solvents: Benzene ;  cooled; rt; overnight, rt

Reference

Preparation of [(Fluoroalkoxy)benzylamino]piperidine derivatives as substance P receptor antagonists

, United States, , ,

Production Method 2

94651-33-9

Reaction Conditions

Reference

Preparation of pyrimidine derivatives as modulators of insulin-like growth factor-1 receptor (IGF-1)

, World Intellectual Property Organization, , ,

Production Method 3

927-84-4

100-52-7

94651-33-9

659-28-9

52771-21-8

Reaction Conditions

1.1 Catalysts: Ruthenium(2+), tris(4,4′-dimethyl-2,2′-bipyridine-κN1,κN1′)-, (OC-6-11)-, hexafl… Solvents: Acetonitrile ;  cooled; 16 h, rt

Reference

Radical C-H Trifluoromethoxylation of (Hetero)arenes with Bis(trifluoromethyl)peroxide

Dix, Stefan; Golz, Paul; Schmid, Jonas R. ; Riedel, Sebastian ; Hopkinson, Matthew N., Chemistry - A European Journal, 2021, 27(45), 11554-11558

Production Method 4

2246643-75-2

100-52-7

37181-39-8

94651-33-9

659-28-9

52771-21-8

Reaction Conditions

1.1 Catalysts: Tris(2,2′-bipyridine)ruthenium(2+) bis(hexafluorophosphate) Solvents: Acetonitrile ;  1 h, rt

Reference

Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow

Nyuchev, Alexander V. ; Wan, Ting ; Cendon, Borja; Sambiagio, Carlo ; Struijs, Job J. C. ; et al, Beilstein Journal of Organic Chemistry, 2020, 16, 1305-1312

Production Method 5

1821034-39-2

98837-98-0

100-52-7

94651-33-9

659-28-9

52771-21-8

Reaction Conditions

1.1 Catalysts: Tris(2,2′-bipyridine)ruthenium(2+) bis(hexafluorophosphate) Solvents: Acetonitrile ;  1 h, rt

Reference

Radical Trifluoromethoxylation of Arenes Triggered by a Visible-Light-Mediated N-O Bond Redox Fragmentation

Jelier, Benson J. ; Tripet, Pascal F. ; Pietrasiak, Ewa; Franzoni, Ivan ; Jeschke, Gunnar ; et al, Angewandte Chemie, 2018, 57(42), 13784-13789

Production Method 6

100-52-7

1479-49-8

94651-33-9

659-28-9

52771-21-8

Reaction Conditions

1.1 Reagents: Potassium carbonate Catalysts: Tris(2,2′-bipyridine)ruthenium(2+) bis(hexafluorophosphate) Solvents: Acetonitrile ;  16 h, rt

Reference

Photocatalytic preparation of perfluoroalkoxy-substituted arenes and heteroarenes

, World Intellectual Property Organization, , ,

Production Method 7

456-55-3

94651-33-9

Reaction Conditions

1.1 Reagents: N,N,N′,N′-Tetramethylethylenediamine Solvents: Tetrahydrofuran
1.2 Reagents: sec-Butyllithium Solvents: Cyclohexane
1.3 -

Reference

2-, 3-, and 4-(trifluoromethoxy)phenyllithiums: versatile intermediates offering access to a variety of new organofluorine compounds

Castagnetti, Eva; Schlosser, Manfred, European Journal of Organic Chemistry, 2001, (4), 691-695

Production Method 8

90-02-8

94651-33-9

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ;  reflux

Reference

Preparation of secondary amine compounds as tRNA synthetase inhibitors useful in killing Gram-negative bacteria

, World Intellectual Property Organization, , ,

Production Method 9

94651-33-9

Reaction Conditions

Reference

Simultaneous Chirality Sensing of Multiple Amines by 19F NMR

Zhao, Yanchuan; Swager, Timothy M., Journal of the American Chemical Society, 2015, 137(9), 3221-3224

Production Method 10

94651-33-9

Reaction Conditions

Reference

Intramolecular hydroxycarbene C-H-insertion: the curious case of (o-methoxyphenyl)hydroxycarbene

Gerbig, Dennis; Ley, David; Reisenauer, Hans Peter; Schreiner, Peter R., Beilstein Journal of Organic Chemistry, 2010, 6, 1061-1069

Production Method 11

94651-33-9

Reaction Conditions

Reference

Preparation of 3-[(fluoroalkoxy)benzylamino]piperidines and analogs as substance P antagonists

, World Intellectual Property Organization, , ,

Production Method 12

94651-33-9

Reaction Conditions

Reference

Aromatic aldehydes

, Federal Republic of Germany, , ,

Production Method 13

4885-02-3

456-55-3

94651-33-9

659-28-9

Reaction Conditions

1.1 Reagents: Aluminum chloride Solvents: Benzene ;  -78 °C; -78 °C → rt; overnight, rt
1.2 Reagents: Water

Reference

Preparation of fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles as substance P receptor antagonists

, United States, , ,

2-(Trifluoromethoxy)benzaldehyde Raw materials

• Pyridinium, 4-cyano-1-(trifluoromethoxy)-
• Peroxide,bis(trifluoromethyl)
• 2-Hydroxybenzaldehyde
• N-Propyl-Methyl Piperidinium Bis(trifluoroMethylsulfonyl)Imide
• 1H-Benzotriazolium, 1-methyl-7-nitro-3-(trifluoromethoxy)-5-(trifluoromethyl)-
• 1,1-Dichlorodimethyl ether
• (Trifluoromethoxy)benzene
• Benzaldehyde
• Methane, oxybis[trifluoro-

2-(Trifluoromethoxy)benzaldehyde Preparation Products

• 4-(Trifluoromethoxy)benzaldehyde (659-28-9)
• 2-(Trifluoromethoxy)benzaldehyde (94651-33-9)
• 3-(Trifluoromethoxy)benzaldehyde (52771-21-8)

• 1. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210
• 2. An atlas of endohedral Sc2S cluster fullerenes?
  Li-Hua Gan,Rui Wu,Jian-Lei Tian,Patrick W. Fowler Phys. Chem. Chem. Phys., 2017,19, 419-425
• 3. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
• 4. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 5. An Appraisal of pH triggered Bacitracin drug release, through composite hydrogel systems
  RabailGul,MariamMir,MurtazaNAli

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Phenol ethers
• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers
• Solvents and Organic Chemicals Organic Compounds Aldehyde/Ketone

• 71663-53-1(2-(Difluoromethoxy)benzaldehyde)
• 66988-93-0((difluoromethoxy)benzaldehyde)
• 71653-64-0(2-(Difluoromethoxy)benzaldehyde)
• 93249-62-8(2-Hydroxy-5-(trifluoromethoxy)benzaldehyde)
• 145742-58-1(Benzaldehyde, 2,5-bis(difluoromethoxy)-)
• 886503-52-2(4-methoxy-2-(trifluoromethoxy)benzaldehyde)
• 886500-13-6(2-Methoxy-4-(trifluoromethoxy)benzaldehyde)
• 145742-65-0(2-Methoxy-5-(trifluoromethoxy)benzaldehyde)
• 145742-61-6(Benzaldehyde, 2-(difluoromethoxy)-5-(trifluoromethoxy)-)
• 1017083-37-2(4-Hydroxy-2-(trifluoromethoxy)benzaldehyde)