Production Method 1

36748-74-0

946427-72-1

Reaction Conditions

1.1 Reagents: Boron tribromide Solvents: Dichloromethane ;  < 5 °C; 6 h, 10 °C
1.2 Reagents: Water ;  cooled; 18 h, 0 °C - rt

Reference

Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene A4 hydrolase and their preparation and use in the treatment of diseases

, World Intellectual Property Organization, , ,

Production Method 2

946427-72-1

Reaction Conditions

Reference

Aryl carboxylic acid cyclohexyl amide derivatives

, United States, , ,

Production Method 3

36748-74-0

946427-72-1

Reaction Conditions

1.1 Reagents: Aluminum chloride Solvents: Dichloromethane ;  10 min, 0 °C
1.2 Reagents: Ethanethiol ;  0 °C; 3 h, 0 °C
1.3 Reagents: Hydrochloric acid ,  Ammonium chloride Solvents: Water ;  0 °C

Reference

Structure based design and evaluation of benzoheterocycle derivatives as potential dual HIV-1 protease and reverse transcriptase inhibitors

Zhu, Mei; Shan, Qi; Ma, Ling; Dong, Biao; Wang, Juxian; et al, European Journal of Medicinal Chemistry, 2023, 246,

Production Method 4

36748-74-0

946427-72-1

Reaction Conditions

1.1 Reagents: Boron tribromide Solvents: Dichloromethane ;  -78 °C; 60 min, 0 °C
1.2 Reagents: Methanol ;  10 min

Reference

Preparation of 3-phenylisoxazole derivatives for treatment of dyslipidemia

, World Intellectual Property Organization, , ,

Production Method 5

95-01-2

946427-72-1

Reaction Conditions

1.1 Reagents: Boron trifluoride etherate Solvents: Dichloromethane ;  < 36 °C; 30 min, 28 °C
1.2 Reagents: p-Toluenesulfonic acid Solvents: Water ;  28 °C; 2 h, 28 °C
1.3 Reagents: Sodium bicarbonate ;  neutralized

Reference

Triazinopyrrole- and quinoline-urea derivatives as tyrosine kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer

, World Intellectual Property Organization, , ,

Production Method 6

36748-74-0

946427-72-1

Reaction Conditions

1.1 Reagents: Boron tribromide Solvents: Dichloromethane ;  rt → 0 °C; 2 h, rt
1.2 Reagents: Water ;  cooled
1.3 Reagents: Sodium bicarbonate Solvents: Water ;  neutralized

Reference

Preparation of N-piperidinylethylcyclohexyl indolecarboxamide derivatives as inhibitors of chemokine receptors or macrophage protein

, World Intellectual Property Organization, , ,

6-Hydroxy-benzofuran-3-carboxylic acid ethyl ester Raw materials

• Ethyl 6-methoxybenzofuran-3-carboxylate
• 2,4-Dihydroxybenzaldehyde

6-Hydroxy-benzofuran-3-carboxylic acid ethyl ester Preparation Products

• 6-Hydroxy-benzofuran-3-carboxylic acid ethyl ester (946427-72-1)

• 1. An analysis of the WTC fires using CIB correlations and simple modeling
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzofurans Benzofurans
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