Production Method 1

17282-04-1

946127-54-4

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ;  -78 °C; 2 h, -78 °C
1.2 -78 °C; 2 h, 0 °C
1.3 Reagents: Sodium borohydride ;  1 h, 0 °C

Reference

Preparation of 2-oxo-2H-benzopyran derivatives and benzo[e][1,3]oxazine-2,4-dione derivatives as P27 protein inducers

, World Intellectual Property Organization, , ,

Production Method 2

628691-93-0

946127-54-4

Reaction Conditions

1.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Tetrahydrofuran ;  overnight, rt
1.2 Reagents: Sodium borohydride Solvents: Water ;  10 min, 0 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ;  0 °C

Reference

Indole compounds or analogs thereof as complement factor D inhibitors useful for the treatment of age-related macular degeneration and their preparation

, World Intellectual Property Organization, , ,

Production Method 3

946127-54-4

Reaction Conditions

Reference

Preparation of coumarin derivatives as antitumor agents

, World Intellectual Property Organization, , ,

Production Method 4

329794-28-7

946127-54-4

Reaction Conditions

1.1 Reagents: Sodium borohydride Solvents: Methanol ;  0 °C; 1 h, rt
1.2 Solvents: Water ;  acidified, 0 °C

Reference

Preparation of substituted coumarins as MEK inhibitors and therapeutic uses thereof

, World Intellectual Property Organization, , ,

Production Method 5

628691-93-0

946127-54-4

Reaction Conditions

1.1 Reagents: Isobutyl chloroformate ,  N-Methyl-2-pyrrolidone Solvents: Tetrahydrofuran ;  0 °C; 1 h, 0 °C
1.2 Reagents: Sodium borohydride ;  30 min, 0 °C
1.3 Reagents: Potassium bisulfate Solvents: Water

Reference

Preparation of benzothiazoles as CSF-1R inhibitors for the treatment of cancer and other diseases

, World Intellectual Property Organization, , ,

Production Method 6

17282-04-1

946127-54-4

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ;  -78 °C; 2 h, -78 °C
1.2 -78 °C → rt; 2 h, rt
1.3 Reagents: Sodium borohydride ;  1 h, 0 °C

Reference

Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen Scanning

Aoki, Toshihiro; Hyohdoh, Ikumi; Furuichi, Noriyuki; Ozawa, Sawako; Watanabe, Fumio; et al, ACS Medicinal Chemistry Letters, 2014, 5(4), 309-314

Production Method 7

946127-54-4

Reaction Conditions

Reference

Coumarin compounds and uses thereof

, World Intellectual Property Organization, , ,

(2-Chloro-3-fluoropyridin-4-yl)methanol Raw materials

• 2-chloro-3-fluoropyridine-4-carboxylic acid
• 2-chloro-3-fluoro-pyridine
• 2-Chloro-3-fluoro-4-formylpyridine

(2-Chloro-3-fluoropyridin-4-yl)methanol Preparation Products

• (2-Chloro-3-fluoropyridin-4-yl)methanol (946127-54-4)

• 1. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
• 2. Distributed research: a new paradigm for undergraduate research and global problem solving?
  Bruce Parkinson Energy Environ. Sci., 2010,3, 509-511
• 3. Fe3O4/PEG-SO3H as a heterogeneous and magnetically-recyclable nanocatalyst for the oxidation of sulfides to sulfones or sulfoxides
  Saeideh Mirfakhraei,Malak Hekmati,Fereshteh Hosseini Eshbala,Hojat Veisi New J. Chem., 2018,42, 1757-1761
• 4. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
• 5. Fe3O4@PANI: a magnetic polyaniline nanomaterial for highly efficient and handy enrichment of intact N-glycopeptides??
  Zhizhen Lai,Mo Zhang,Jinyu Zhou,Tianjing Chen,Dan Li,Xuejing Shen,Jia Liu,Jiang Zhou,Zhili Li Analyst, 2021,146, 4261-4267

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines Polyhalopyridines

• 628691-93-0(2-chloro-3-fluoropyridine-4-carboxylic acid)
• 922147-45-3(2-Chloro-3-Fluoro-4-Carboxypyridine)
• 1196156-07-6(2-Chloro-3-fluoro-4-formylpyridine hydrate)
• 628691-95-2(methyl 2-chloro-3-fluoropyridine-4-carboxylate)
• 881891-83-4(2-Chloro-5-fluoro-4-methylpyridine)
• 884494-86-4((2-Chloro-5-fluoropyridin-4-yl)methanol)
• 881891-82-3(2-chloro-3-fluoro-4-methyl-pyridine)
• 329794-28-7(2-Chloro-3-fluoro-4-formylpyridine)
• 1174028-24-0((6-chloro-5-fluoropyridin-3-yl)methanol)
• 884494-74-0(2-Chloro-5-fluoroisonicotinic acid)