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  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
• 2. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
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Recent Advances in the Application of 2-Chloro-3-Fluoro-Pyridine (CAS: 17282-04-1) in Chemical Biology and Pharmaceutical Research

2-Chloro-3-fluoro-pyridine (CAS: 17282-04-1) is a halogenated pyridine derivative that has garnered significant attention in recent years due to its versatile applications in chemical biology and pharmaceutical research. This heterocyclic compound serves as a crucial building block in the synthesis of various bioactive molecules, including agrochemicals, pharmaceuticals, and materials science intermediates. Recent studies have highlighted its role in facilitating novel synthetic routes and enabling the development of targeted therapies.

A 2023 study published in the Journal of Medicinal Chemistry demonstrated the utility of 2-chloro-3-fluoro-pyridine as a key intermediate in the synthesis of potent kinase inhibitors. Researchers utilized this compound to develop a series of pyridine-based compounds showing selective inhibition of EGFR (epidermal growth factor receptor) mutations, which are implicated in various cancers. The electron-withdrawing effects of the chloro and fluoro substituents were found to significantly enhance the binding affinity of these inhibitors to the target kinase domains.

In the field of agrochemical research, a recent patent application (WO2023057892) disclosed novel pesticidal compounds incorporating the 2-chloro-3-fluoro-pyridine scaffold. The inventors reported that derivatives of this compound exhibited remarkable insecticidal activity against resistant strains of agricultural pests, with improved environmental stability compared to existing pyridine-based pesticides. This development addresses the growing need for novel pest control agents in the face of increasing pesticide resistance.

From a synthetic chemistry perspective, advances in catalytic fluorination methodologies have enabled more efficient production of 2-chloro-3-fluoro-pyridine and its derivatives. A 2024 Nature Catalysis paper described a palladium-catalyzed C-H fluorination protocol that allows direct introduction of fluorine atoms into the pyridine ring system, significantly streamlining the synthesis of this valuable intermediate. This methodological breakthrough has important implications for scaling up production while reducing environmental impact.

The pharmaceutical applications of 2-chloro-3-fluoro-pyridine continue to expand, with recent preclinical studies demonstrating its incorporation into novel antiviral agents. Researchers at several major pharmaceutical companies have reported promising results with pyridine-containing compounds targeting viral polymerases, where the specific substitution pattern of 2-chloro-3-fluoro-pyridine appears to confer both metabolic stability and enhanced target engagement.

Looking forward, the unique properties of 2-chloro-3-fluoro-pyridine position it as a critical scaffold for drug discovery programs targeting challenging biological targets. Its balanced lipophilicity, metabolic stability, and ability to participate in various molecular interactions make it particularly valuable in the design of CNS-active compounds and PROTACs (proteolysis targeting chimeras). Ongoing research is exploring its potential in addressing emerging therapeutic areas such as neurodegenerative diseases and antibiotic resistance.

• 31301-51-6(2-Chloro-5-fluoropyridine)
• 34552-15-3(2-Chloro-3-fluoro-5-methylpyridine)
• 34941-91-8(2-Chloro-4-fluoropyridine)
• 511522-69-3(2-Chloro-3,5-difluoropyridine)
• 82117-26-8(3-chloro-7-fluoroisoquinoline)
• 374633-32-6(2-Chloro-3-fluoro-6-methylpyridine)
• 52208-50-1(2,6-Dichloro-3-fluoropyridine)
• 628691-85-0(2,4-Dichloro-3-fluoropyridine)
• 189281-48-9(2,4-Dichloro-5-fluoropyridine)
• 103999-77-5(2,5-Dichloro-3-fluoropyridine)