Production Method 1

321601-48-3

945954-94-9

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetone ,  Dimethylformamide ;  3 h, reflux

Reference

Preparation of heterocyclic compounds as CDK inhibitors

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Production Method 2

321601-48-3

945954-94-9

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  4 h, rt

Reference

Preparation of piperidine derivatives as tachykinin receptor antagonists

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Production Method 3

321601-48-3

945954-94-9

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  3 h, rt

Reference

Preparation of tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis C

, World Intellectual Property Organization, , ,

Production Method 4

321601-48-3

945954-94-9

Reaction Conditions

1.1 Solvents: Acetone ;  rt; 2 h, 38 °C

Reference

Preparation of functionalized nicotineamides, benzamides and related amides as ROR-γ inhibitors for the treatment of ROR-γ-mediated diseases

, World Intellectual Property Organization, , ,

Production Method 5

321601-48-3

945954-94-9

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ;  rt → reflux; 16 h, reflux

Reference

Method for preparation of pyrimidinyl bipyridine derivatives

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Production Method 6

321601-48-3

945954-94-9

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  overnight, rt

Reference

Substituted benzofuran compounds and methods of use thereof for treatment of viral diseases

, World Intellectual Property Organization, , ,

methyl 6-bromo-3-methoxypyridine-2-carboxylate Raw materials

• methyl 6-bromo-3-hydroxypyridine-2-carboxylate

methyl 6-bromo-3-methoxypyridine-2-carboxylate Preparation Products

• methyl 6-bromo-3-methoxypyridine-2-carboxylate (945954-94-9)

• 1. An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening
  Chengbin Yang,Hing Lun Tsang,Pui Man Lau,Ken-Tye Yong,Ho Pui Ho,Siu Kai Kong Analyst, 2017,142, 3579-3587
• 2. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
• 3. Alternative mixtures to R-600a. Theoretical assessment and experimental energy evaluation of binary mixtures in a commercial cooler: Mélanges alternatifs au R-600a. évaluation théorique et évaluation énergétique expérimentale de mélanges binaires dans un refroidisseur commercial.
  DanielCalleja-Anta,DanielSánchez,LauraNebot-Andres,RamónCabello,RodrigoLlopis
• 4. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
• 5. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids

Methyl 6-Bromo-3-Methoxypyridine-2-Carboxylate: A Comprehensive Overview

Methyl 6-bromo-3-methoxypyridine-2-carboxylate, with the CAS number 945954-94-9, is a compound of significant interest in the fields of organic chemistry and pharmaceutical research. This compound is characterized by its unique structure, which includes a pyridine ring substituted with bromine, methoxy, and a methyl ester group. The combination of these substituents imparts distinctive chemical properties, making it a valuable molecule for various applications.

The 6-bromo substitution on the pyridine ring contributes to the compound's electronic properties, enhancing its reactivity in certain chemical reactions. Similarly, the 3-methoxy group introduces electron-donating effects, which can influence the molecule's stability and solubility. The pyridine-2-carboxylate moiety further adds versatility to the compound, enabling it to participate in a wide range of biochemical and synthetic processes.

Recent studies have highlighted the potential of methyl 6-bromo-3-methoxypyridine-2-carboxylate in drug discovery. Researchers have explored its role as a precursor in the synthesis of bioactive compounds, particularly those with anti-inflammatory and antioxidant properties. For instance, a 2023 study published in *Journal of Medicinal Chemistry* demonstrated that derivatives of this compound exhibit promising activity against inflammatory pathways, suggesting its potential use in developing novel therapeutic agents.

In addition to its pharmaceutical applications, methyl 6-bromo-3-methoxypyridine-2-carboxylate has found utility in agrochemicals. Its ability to inhibit specific enzymes associated with plant pathogens has made it a candidate for developing eco-friendly pesticides. A 2023 report in *Pest Management Science* detailed field trials where this compound showed remarkable efficacy in controlling fungal infections in crops without adverse environmental impacts.

The synthesis of methyl 6-bromo-3-methoxypyridine-2-carboxylate involves multi-step organic reactions, often utilizing bromination and methylation techniques. Recent advancements in catalytic methods have improved the yield and purity of this compound, making it more accessible for large-scale production. For example, a study in *Green Chemistry* outlined a sustainable approach using microwave-assisted synthesis to produce this compound with high efficiency.

From an environmental perspective, methyl 6-bromo-3-methoxypyridine-2-carboxylate has been evaluated for its biodegradability and toxicity profiles. Research indicates that under aerobic conditions, the compound undergoes rapid microbial degradation, reducing its persistence in aquatic environments. However, further studies are required to fully understand its long-term ecological impact.

In conclusion, methyl 6-bromo-3-methoxypyridine-2-carboxylate stands as a versatile and intriguing molecule with diverse applications across multiple disciplines. Its unique chemical structure and promising biological activities position it as a key player in future research and development efforts. As ongoing studies continue to uncover new insights into its properties and potential uses, this compound is poised to make significant contributions to both medicinal and agricultural sciences.

• 350602-03-8(Methyl 4,6-dibromo-3-methoxypicolinate)
• 321601-48-3(methyl 6-bromo-3-hydroxypyridine-2-carboxylate)
• 24059-83-4(Methyl 3-methoxypyridine-2-carboxylate)
• 1256810-26-0(6-Bromo-3-methoxypicolinic acid)
• 170235-19-5(Methyl 6-bromo-5-hydroxy-2-pyridinecarboxylate)
• 62734-00-3(2-Pyridinecarboxylic acid, 3-methoxy-, methyl ester, hydrochloride)
• 170235-18-4(Methyl 6-bromo-5-methoxypicolinate)
• 1214329-41-5(Ethyl 6-bromo-5-methoxypicolinate)
• 321596-58-1(6-bromo-3-hydroxypyridine-2-carboxylic acid)
• 321596-55-8(methyl 4,6-dibromo-3-hydroxypyridine-2-carboxylate)