Production Method 1

3934-20-1

765-30-0

945895-52-3

Reaction Conditions

1.1 Solvents: Ethanol ;  24 - 48 h, rt

Reference

Preparation of substituted pyrimidinylpiperazines as antiviral compounds

, World Intellectual Property Organization, , ,

Production Method 2

3934-20-1

765-30-0

945895-52-3

Reaction Conditions

1.1 Reagents: Diisopropylethylamine Solvents: Dichloromethane ;  24 h, rt

Reference

Discovery of novel 2,4-disubstituted pyrimidines as Aurora kinase inhibitors

Xu, Yu; Hao, Shu-Yi; Zhang, Xiu-Juan; Li, Wen-Bo; Qiao, Xue-Peng; et al, Bioorganic & Medicinal Chemistry Letters, 2020, 30(3),

Production Method 3

3934-20-1

765-30-0

945895-52-3

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  overnight, rt

Reference

Preparation of quinolinone-linked pyrimidines compounds as mutant-isocitrate dehydrogenase inhibitors

, World Intellectual Property Organization, , ,

Production Method 4

3934-20-1

765-30-0

945895-52-3

Reaction Conditions

1.1 Solvents: Dichloromethane ;  16 h, rt

Reference

Discovery of a Diaminopyrimidine FLT3 Inhibitor Active against Acute Myeloid Leukemia

Jarusiewicz, Jamie A.; Jeon, Jae Yoon; Connelly, Michele C.; Chen, Yizhe; Yang, Lei; et al, ACS Omega, 2017, 2(5), 1985-2009

Production Method 5

945895-52-3

Reaction Conditions

Reference

Identification of 2-(4-(Phenylsulfonyl)piperazine-1-yl)pyrimidine Analogues as Novel Inhibitors of Chikungunya Virus

Moesslacher, Julia; Battisti, Verena ; Delang, Leen; Neyts, Johan; Abdelnabi, Rana; et al, ACS Medicinal Chemistry Letters, 2020, 11(5), 906-912

Production Method 6

3934-20-1

765-30-0

945895-52-3

1044771-76-7

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: 1,4-Dioxane ;  rt; overnight, rt

Reference

Pyrimidinyl Biphenylureas: Identification of New Lead Compounds as Allosteric Modulators of the Cannabinoid Receptor CB1

Khurana, Leepakshi; Fu, Bo-Qiao; Duddupudi, Anantha L.; Liao, Yu-Hsien; Immadi, Sri Sujana; et al, Journal of Medicinal Chemistry, 2017, 60(3), 1089-1104

2-Chloro-N-cyclopropylpyrimidin-4-amine Raw materials

• 2,4-Dichloropyrimidine
• cyclopropanamine

2-Chloro-N-cyclopropylpyrimidin-4-amine Preparation Products

• 2-Chloro-N-cyclopropylpyrimidin-4-amine (945895-52-3)
• 4-chloro-N-cyclopropylpyrimidin-2-amine (1044771-76-7)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Aminopyrimidines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Aminopyrimidines and derivatives

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