Production Method 1

262423-77-8

945543-24-8

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  2 h, 60 °C
1.2 Reagents: Sodium borohydride Solvents: Water ;  0 °C; 4 h, 60 °C

Reference

N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists

Doebelin, Christelle; Patouret, Remi; Garcia-Ordonez, Ruben D.; Chang, Mi Ra; Dharmarajan, Venkatasubramanian; et al, ChemMedChem, 2016, 11(23), 2607-2620

Production Method 2

62022-04-2

945543-24-8

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride Solvents: Tetrahydrofuran ;  4 °C; 15 min, 4 °C; overnight, rt

Reference

Morpholines and related compounds as S1P agonists and their preparation and use for the treatment of S1P-mediated diseases

, World Intellectual Property Organization, , ,

Production Method 3

62022-04-2

945543-24-8

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride Solvents: Tetrahydrofuran ;  4 °C; 15 min, 4 °C; overnight, rt

Reference

Preparation of spirocyclic amine derivatives for use as S1P modulators

, World Intellectual Property Organization, , ,

Production Method 4

134031-24-6

945543-24-8

Reaction Conditions

1.1 Reagents: Sodium borohydride Solvents: Ethanol ;  1 h, rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  rt

Reference

Preparation of heteroarylmethoxyquinolines as bradykinin B2 receptor modulators

, World Intellectual Property Organization, , ,

Production Method 5

134031-24-6

945543-24-8

Reaction Conditions

1.1 Reagents: Sodium borohydride Solvents: Methanol ;  3 h, 0 °C; 2 h, 0 °C → rt

Reference

Preparation of substituted 2-imidazole imidazoline derivatives for the treatment of diseases related to trace amine associated receptors

, World Intellectual Property Organization, , ,

Production Method 6

945543-24-8

Reaction Conditions

Reference

Preparation of phthalazine derivatives as pyruvate kinase modulators

, World Intellectual Property Organization, , ,

2,4-Dichloropyridine-3-methanol Raw materials

• Ethyl 2,4-dichloronicotinate
• 2,4-dichloropyridine-3-carbaldehyde
• 2,4-Dichloropyridine-3-carboxylic acid

2,4-Dichloropyridine-3-methanol Preparation Products

• 2,4-Dichloropyridine-3-methanol (945543-24-8)

• 1. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210
• 2. An assessment of strategies for the development of solid-state adsorbents for vehicular hydrogen storage
  Mark D. Allendorf,Alauddin Ahmed,Tom Autrey,Jeffrey Camp,Eun Seon Cho,Maciej Haranczyk,Abhi Karkamkar,Di-Jia Liu,Katie R. Meihaus,Iffat H. Nayyar,Roman Nazarov,Donald J. Siegel,Vitalie Stavila,Jeffrey J. Urban,Srimukh Prasad Veccham,Brandon C. Wood Energy Environ. Sci., 2018,11, 2784-2812
• 3. An intensified π-hole in beryllium-doped boron nitride meshes: its determinant role in CO2 conversion into hydrocarbon fuels?
  Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551
• 4. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 5. Acetyl group orientation modulates the electronic ground-state asymmetry of the special pair in purple bacterial reaction centers
  P. K. Wawrzyniak,M. T. P. Beerepoot,H. J. M. de Groot,F. Buda Phys. Chem. Chem. Phys., 2011,13, 10270-10279

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines Polyhalopyridines

• 558465-93-3((2,5-Dichloropyridin-3-yl)methanol)
• 518314-64-2((2-chloro-5-methylpyridin-3-yl)methanol)
• 1017403-83-6( )
• 374800-25-6((2,4-dichloro-6-methyl-3-pyridyl)methanol)
• 132097-09-7(2,4-Dichloro-3-methylpyridine)
• 42330-59-6((2-chloropyridin-3-yl)methanol)
• 1218994-36-5((2,4,6-Trichloropyridin-3-yl)methanol)
• 262423-77-8(2,4-Dichloropyridine-3-carboxylic acid)
• 55304-90-0((2,6-Dichloropyridin-3-yl)methanol)
• 73998-95-5((4,6-Dichloropyridin-3-yl)methanol)