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  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 2. Distinction of trans–cis photoisomers with comparable optical properties in multiple-state photochromic systems – examining a molecule with three azobenzenes via in situ irradiation NMR spectroscopy?
  Jonas Kind,Lukas Kaltschnee,Martin Leyendecker,Christina M. Thiele Chem. Commun., 2016,52, 12506-12509
• 3. Emerging investigators
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  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridine carboxaldehydes

Introduction to 2,4-dichloropyridine-3-carbaldehyde (CAS No. 134031-24-6)

2,4-dichloropyridine-3-carbaldehyde, identified by the Chemical Abstracts Service Number (CAS No.) 134031-24-6, is a significant intermediate in the field of organic synthesis and pharmaceutical chemistry. This compound, featuring a pyridine core with chloro and aldehyde functional groups, has garnered considerable attention due to its versatile reactivity and utility in constructing complex molecular architectures.

The structural motif of 2,4-dichloropyridine-3-carbaldehyde consists of a six-membered aromatic ring substituted with two chlorine atoms at the 2- and 4-positions, and an aldehyde group at the 3-position. This unique arrangement imparts distinct electronic and steric properties, making it a valuable building block for synthesizing various heterocyclic compounds. The presence of the aldehyde functionality further enhances its reactivity, enabling participation in condensation reactions, nucleophilic additions, and oxidation processes.

In recent years, 2,4-dichloropyridine-3-carbaldehyde has been extensively explored in the development of pharmaceuticals and agrochemicals. Its derivatives have shown promise as intermediates in the synthesis of active pharmaceutical ingredients (APIs) targeting diverse therapeutic areas. For instance, studies have demonstrated its role in constructing novel inhibitors for enzymatic targets involved in inflammatory diseases and infectious disorders.

One of the most compelling applications of 2,4-dichloropyridine-3-carbaldehyde lies in its use as a precursor for biologically active molecules. Researchers have leveraged its reactivity to develop small-molecule probes for studying protein-protein interactions and as scaffolds for designing kinase inhibitors. The pyridine core is particularly amenable to functionalization, allowing chemists to tailor properties such as solubility, bioavailability, and metabolic stability.

Advances in synthetic methodologies have further expanded the utility of CAS No. 134031-24-6. Modern techniques such as transition-metal-catalyzed cross-coupling reactions and asymmetric hydrogenation have enabled the efficient preparation of enantiomerically pure derivatives, which are crucial for developing chiral drugs with enhanced pharmacological profiles. These innovations underscore the compound's importance in medicinal chemistry.

The compound's significance extends beyond pharmaceuticals into materials science. Functionalized pyridine derivatives derived from 2,4-dichloropyridine-3-carbaldehyde have been investigated for their potential applications in organic electronics, including light-emitting diodes (OLEDs) and photovoltaic devices. The electron-withdrawing nature of the aldehyde group and the electron-donating effects of chlorine atoms contribute to tunable electronic properties, making these derivatives attractive for optoelectronic applications.

In academic research, 2,4-dichloropyridine-3-carbaldehyde continues to serve as a versatile tool for exploring new synthetic pathways and understanding reaction mechanisms. Its incorporation into complex molecular frameworks has facilitated breakthroughs in catalysis and polymer chemistry. For example, researchers have utilized this compound to develop novel catalysts for carbon-carbon bond formation and to engineer polymers with tailored thermal and mechanical properties.

The industrial production of CAS No. 134031-24-6 is optimized for scalability while maintaining high purity standards. Manufacturers employ advanced purification techniques such as distillation under reduced pressure and recrystallization from appropriate solvents to ensure that the final product meets stringent quality requirements. These measures are essential for downstream applications where impurities can adversely affect reaction outcomes or biological activity.

Future research directions involving 2,4-dichloropyridine-3-carbaldehyde are likely to focus on expanding its applications in drug discovery and material science. Emerging fields such as artificial intelligence-assisted drug design are expected to accelerate the identification of novel derivatives with enhanced therapeutic potential. Additionally, sustainable synthetic routes will be prioritized to minimize environmental impact while maximizing efficiency.

In summary,2,4-dichloropyridine-3-carbaldehyde (CAS No. 134031-24-6) represents a cornerstone in modern chemical synthesis. Its unique structural features and reactivity make it indispensable for developing pharmaceuticals, agrochemicals, and advanced materials. As research progresses，this compound will undoubtedly continue to play a pivotal role in shaping the future of chemical innovation.

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