• 1. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 2. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 3. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 4. Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides?
  Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615
• 5. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Halopyrimidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Halopyrimidines

1-(4-Chloropyrimidin-2-yl)methanamine (CAS No. 944902-16-3): A Versatile Chemical Building Block for Pharmaceutical and Agrochemical Applications

In the ever-evolving landscape of chemical research and development, 1-(4-chloropyrimidin-2-yl)methanamine (CAS No. 944902-16-3) has emerged as a crucial intermediate with significant potential in pharmaceutical and agrochemical applications. This chloropyrimidine derivative belongs to the important class of heterocyclic compounds, which are increasingly sought after in modern drug discovery and crop protection formulations.

The molecular structure of 1-(4-chloropyrimidin-2-yl)methanamine features a pyrimidine ring substituted with a chlorine atom at the 4-position and an aminomethyl group at the 2-position. This unique arrangement contributes to its valuable chemical properties, making it an attractive building block for synthesizing more complex molecules. Recent studies highlight its growing importance in developing kinase inhibitors, a hot topic in cancer research and targeted therapies.

From a synthetic chemistry perspective, 944902-16-3 offers multiple reactive sites that allow for diverse chemical transformations. The chlorine substituent provides an excellent handle for nucleophilic aromatic substitution reactions, while the primary amine group can participate in condensation, acylation, or reductive amination reactions. These characteristics make it particularly valuable in combinatorial chemistry and high-throughput screening applications, addressing current industry demands for efficient drug discovery platforms.

In pharmaceutical applications, 1-(4-chloropyrimidin-2-yl)methanamine serves as a key intermediate in the synthesis of various small molecule drugs. Its structural motif appears in several investigational compounds targeting protein kinases, which are currently one of the most researched topics in medicinal chemistry. The compound's relevance to precision medicine approaches aligns with today's focus on personalized therapeutics and targeted drug delivery systems.

The agrochemical industry also benefits from derivatives of 944902-16-3, particularly in developing novel crop protection agents. As global attention turns toward sustainable agriculture and food security, pyrimidine-based compounds like this one are being investigated for their potential in creating more effective and environmentally friendly pesticides and herbicides. This addresses current market demands for solutions that balance agricultural productivity with ecological considerations.

From a commercial availability standpoint, 1-(4-chloropyrimidin-2-yl)methanamine is typically supplied as a white to off-white crystalline powder with high purity levels (>95%). Proper storage conditions (typically 2-8°C in a dry environment) ensure its stability and shelf life. The compound's physicochemical properties, including solubility characteristics and melting point range, make it suitable for various synthetic applications under standard laboratory conditions.

Recent advancements in green chemistry have also explored more sustainable synthetic routes to 944902-16-3 and its derivatives. This responds to growing industry and regulatory pressures to develop environmentally benign chemical processes. Researchers are investigating catalytic methods and alternative solvents to reduce the environmental impact of producing such valuable intermediates.

Quality control of 1-(4-chloropyrimidin-2-yl)methanamine typically involves analytical techniques such as HPLC, GC-MS, and NMR spectroscopy. These methods ensure batch-to-batch consistency and verify the absence of impurities that could affect downstream applications. The compound's characterization data is crucial for researchers who need to incorporate it into their synthetic schemes with confidence.

The global market for pyrimidine derivatives like 944902-16-3 continues to expand, driven by increasing R&D investments in both pharmaceutical and agrochemical sectors. Market analysts note particular growth in Asia-Pacific regions, where contract research organizations and generic drug manufacturers are actively sourcing high-quality chemical intermediates.

Safety considerations for handling 1-(4-chloropyrimidin-2-yl)methanamine follow standard laboratory protocols for chemical substances. While not classified as highly hazardous, proper personal protective equipment (PPE) including gloves and safety glasses is recommended when working with this compound. Material safety data sheets provide detailed handling instructions for industrial and research applications.

Future research directions for 944902-16-3 and related compounds may focus on developing more efficient synthetic methodologies, exploring new biological activities, and investigating formulation strategies for enhanced bioavailability. The compound's versatility ensures its continued relevance in addressing current challenges in medicinal chemistry and crop science.

For researchers and manufacturers seeking reliable sources of 1-(4-chloropyrimidin-2-yl)methanamine, it's essential to partner with suppliers who can provide comprehensive analytical data, regulatory documentation, and consistent quality. The compound's growing importance in various applications makes it a valuable addition to any chemical inventory focused on heterocyclic chemistry and drug development.

• 1196152-23-4((4-Chloro-6-methylpyrimidin-2-YL)methanamine hydrochloride)
• 1196155-29-9((4-Chloro-5-methylpyrimidin-2-YL)methanamine hydrochloride)
• 898044-48-9(4-chloropyrimidine-2-carbonitrile)
• 933720-62-8(4,6-DICHLORO-2-(AMINOMETHYL)PYRIMIDINE)
• 1196152-29-0((4,6-Dichloropyrimidin-2-YL)methanamine hydrochloride)
• 1780-26-3(4,6-Dichloro-2-methylpyrimidine)
• 1159824-34-6(4-Chloro-2-methylpyrimidine 2HCl)
• 1196153-67-9(1-(4,6-Dichloropyrimidin-2-YL)ethanamine hydrochloride)
• 4994-86-9(4-Chloro-2-methylpyrimidine)
• 1215031-49-4(4-chloro-2-[(4-methyl-1-piperazinyl)methyl]-Pyrimidine)