Cas no 1780-26-3 (4,6-Dichloro-2-methylpyrimidine)
4,6-Dichloro-2-methylpyrimidine Chemical and Physical Properties
Names and Identifiers
-
- 2-Methyl-4,6-dichloropyrimidine
- BUTTPARK 52\14-70
- 2-MDCP
- 4,6-DICHLORO-2-METHYLPYRIMIDINE
- 4,6-Dichloro-2-methylpyrimidiine
- 4,6-dichloro-2-methylpyrimidine4
- 4,6-Dichloro-2-methyl-pyrimidine
- 2-methyl-4,6-dichloro-pyrimidine
- 4,6-dichlor-2-methylpyrimidin
- 4,6-Dimethoxy-2-methylmercapyrimidine
- NSC 35923
- Pyrimidine, 4,6-dichloro-2-methyl-
- 4,6-dichloro-2-methyl pyrimidine
- NSC35923
- PubChem7075
- KSC490S3H
- 4 6-dichloro-2-methylpyrimidine
- 4,6-dichloro-2-methyipyrimidine
- FIMUTBLUWQGTIJ-UHFFFAOYSA-N
- 2-met
- 4,6 dichloro-2-methyl pyrimidine
- BCP30663
- MS-1554
- 2-Methyl-4,6-dichloropyrimidine;Pyrimidine, 4,6-dichloro-2-methyl-;4,6-Dichloro-2-methyl-pyrimidine
- UNII-4UM8PK8RCC
- 4,6-Dichloro-2-methylpyrimidine, 98%
- AM20090054
- AC-5731
- F0001-0649
- AKOS002337366
- EN300-59877
- MFCD00090472
- J-011352
- D3558
- FT-0601163
- SCHEMBL113085
- NS00121322
- DTXSID80284149
- Z916979388
- 4UM8PK8RCC
- 1780-26-3
- NSC-35923
- CS-D1717
- A3952
- Pyrimidine, 4,6-dichloro-2-methyl-; 4,6-Dichloro-2-methylpyrimidine; 2-Methyl-4,6-dichloropyrimidine; NSC 35923
- PB20912
- 4.6-dichloro-2-methyl pyrimidine
- DTXCID50235300
- 605-815-0
- FD11549
- 4,6-Dichloro-2-methylpyrimidine
-
- MDL： MFCD00090472
- Inchi： 1S/C5H4Cl2N2/c1-3-8-4(6)2-5(7)9-3/h2H,1H3
- InChI Key： FIMUTBLUWQGTIJ-UHFFFAOYSA-N
- SMILES： ClC1=CC(=NC(C)=N1)Cl
Computed Properties
- Exact Mass: 161.97500
- Monoisotopic Mass: 161.975
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 9
- Rotatable Bond Count: 0
- Complexity: 89
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 25.8
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: 2.5
Experimental Properties
- Color/Form: Pale-yellow to Yellow-brown Solid
- Density: 1.4040
- Melting Point: 44.0 to 48.0 deg-C
- Boiling Point: 210.8 oCat 760 mmHg
- Flash Point: Fahrenheit: 206.6 ° f
Celsius: 97 ° c - Refractive Index: 1.551
- PSA: 25.78000
- LogP: 2.09180
- Solubility: Not determined
4,6-Dichloro-2-methylpyrimidine Security Information
-
Symbol:
- Prompt：warning
- Signal Word：Danger
- Hazard Statement： H314
- Warning Statement： P280,P305+P351+P338,P310
- Hazardous Material transportation number：UN 3261 8/PG 2
- WGK Germany：3
- Hazard Category Code： 22-43-51/53
- Safety Instruction： S26-S36/37/39-S45
-
Hazardous Material Identification：
- Packing Group：III
- Hazard Level：8
- Risk Phrases：R34
- Packing Group：III
- Safety Term：8
- HazardClass：9
- PackingGroup：None
- Storage Condition：Inert atmosphere,2-8°C
4,6-Dichloro-2-methylpyrimidine Customs Data
- HS CODE：2933599090
- Customs Data：
China Customs Code:
2933599090Overview:
2933599090. Other compounds with pyrimidine ring in structure(Including other compounds with piperazine ring on the structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
4,6-Dichloro-2-methylpyrimidine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | D3558-25g |
4,6-Dichloro-2-methylpyrimidine |
1780-26-3 | 98.0%(GC) | 25g |
￥550.0 | 2022-05-30 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | D3558-5g |
4,6-Dichloro-2-methylpyrimidine |
1780-26-3 | 98.0%(GC) | 5g |
￥150.0 | 2022-05-30 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | D651A-25g |
4,6-Dichloro-2-methylpyrimidine |
1780-26-3 | 98% | 25g |
￥87.0 | 2022-05-30 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | D651A-100g |
4,6-Dichloro-2-methylpyrimidine |
1780-26-3 | 98% | 100g |
￥286.0 | 2022-05-30 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | D651A-5g |
4,6-Dichloro-2-methylpyrimidine |
1780-26-3 | 98% | 5g |
￥33.0 | 2022-05-30 | |
| NAN JING HUA XUE SHI JI GU FEN Co., Ltd. | C0464669467- 1g |
4,6-Dichloro-2-methylpyrimidine |
1780-26-3 | 98%（GC） | 1g |
￥ 56.5 | 2021-05-18 | |
| NAN JING HUA XUE SHI JI GU FEN Co., Ltd. | C0464669451- 5g |
4,6-Dichloro-2-methylpyrimidine |
1780-26-3 | 98%（GC） | 5g |
￥ 89.4 | 2021-05-18 | |
| NAN JING HUA XUE SHI JI GU FEN Co., Ltd. | C0464669443- 25g |
4,6-Dichloro-2-methylpyrimidine |
1780-26-3 | 98%（GC） | 25g |
￥ 230.6 | 2021-05-18 | |
| Fluorochem | 036431-1g |
2-Methyl-4,6-dichloropyrimidine |
1780-26-3 | 97% | 1g |
￡10.00 | 2022-03-01 | |
| Fluorochem | 036431-25g |
2-Methyl-4,6-dichloropyrimidine |
1780-26-3 | 97% | 25g |
￡15.00 | 2022-03-01 |
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4,6-Dichloro-2-methylpyrimidine Related Literature
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1. 147. Synthetic antimalarials. Part VIII. Some 4-arylamino-6-aminoalkylamino-2-methylpyrimidinesF. R. Basford,F. H. S. Curd,F. L. Rose J. Chem. Soc. 1946 713
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2. 251. Synthetic antimalarials. Part XXI. 4-Arylamino-6-aminoalkylaminopyrimidines. Further variationsF. R. Basford,F. H. S. Curd,E. Hoggarth,F. L. Rose J. Chem. Soc. 1947 1354
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Francesco Rodella,Rishabh Saxena,Sergey Bagnich,Dovydas Banevi?ius,Gediminas Kreiza,Stavros Athanasopoulos,Saulius Jur??nas,Karolis Kazlauskas,Anna K?hler,Peter Strohriegl J. Mater. Chem. C 2021 9 17471
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4. The role of the pyrimidine 4-amino-group in thiamineC. D. May,P. Sykes J. Chem. Soc. C 1966 649
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Bowen Li,Zhiyi Li,Taiping Hu,Yong Zhang,Ying Wang,Yuanping Yi,Fengyun Guo,Liancheng Zhao J. Mater. Chem. C 2018 6 2351
Additional information on 4,6-Dichloro-2-methylpyrimidine
Recent Advances in the Application of 4,6-Dichloro-2-methylpyrimidine (CAS: 1780-26-3) in Chemical Biology and Pharmaceutical Research
4,6-Dichloro-2-methylpyrimidine (CAS: 1780-26-3) is a key intermediate in the synthesis of various biologically active compounds, particularly in the development of pharmaceuticals and agrochemicals. Recent studies have highlighted its versatility as a building block for the construction of heterocyclic compounds, which are integral to drug discovery and development. This research brief aims to summarize the latest findings on the applications, synthetic methodologies, and biological activities associated with this compound.
One of the most significant advancements in the use of 4,6-Dichloro-2-methylpyrimidine is its role in the synthesis of kinase inhibitors. Kinases are critical targets in cancer therapy, and recent research has demonstrated the efficacy of pyrimidine-based inhibitors derived from this compound. For instance, a 2023 study published in the Journal of Medicinal Chemistry reported the development of a novel series of EGFR inhibitors using 4,6-Dichloro-2-methylpyrimidine as a core scaffold. These inhibitors showed promising activity against resistant mutations, underscoring the compound's potential in addressing drug resistance in oncology.
In addition to its applications in oncology, 4,6-Dichloro-2-methylpyrimidine has been explored in the context of antimicrobial agents. A recent study in Bioorganic & Medicinal Chemistry Letters detailed the synthesis of pyrimidine derivatives with potent antibacterial activity against Gram-positive pathogens. The researchers utilized 4,6-Dichloro-2-methylpyrimidine as a starting material, demonstrating its utility in the rapid generation of diverse chemical libraries for high-throughput screening.
From a synthetic chemistry perspective, advancements in green chemistry have also impacted the production and modification of 4,6-Dichloro-2-methylpyrimidine. A 2022 publication in ACS Sustainable Chemistry & Engineering introduced a solvent-free, catalyst-assisted method for the chlorination of 2-methylpyrimidine, yielding 4,6-Dichloro-2-methylpyrimidine with high efficiency and minimal environmental impact. This method aligns with the growing emphasis on sustainable practices in pharmaceutical manufacturing.
Looking ahead, the versatility of 4,6-Dichloro-2-methylpyrimidine continues to inspire innovation in drug discovery. Its role in the synthesis of targeted therapies, combined with advancements in sustainable chemistry, positions it as a valuable tool for researchers. Future studies are expected to explore its applications in emerging therapeutic areas, such as neurodegenerative diseases and immunomodulation, further expanding its impact on the pharmaceutical industry.
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