Cas no 19875-05-9 (4,6-Dichloro-2-(chloromethyl)pyrimidine)

4,6-Dichloro-2-(chloromethyl)pyrimidine is a versatile chlorinated pyrimidine derivative widely used as a key intermediate in organic synthesis and pharmaceutical manufacturing. Its reactive chloromethyl and dichloro substituents make it a valuable building block for nucleophilic substitution reactions, enabling the introduction of pyrimidine scaffolds into more complex structures. The compound is particularly useful in the synthesis of agrochemicals, antiviral agents, and other biologically active molecules. Its high purity and stability under controlled conditions ensure reliable performance in multi-step synthetic routes. The structural flexibility offered by its functional groups allows for efficient derivatization, making it a preferred choice for researchers developing novel heterocyclic compounds.
4,6-Dichloro-2-(chloromethyl)pyrimidine structure
19875-05-9 structure
Product Name:4,6-Dichloro-2-(chloromethyl)pyrimidine
CAS No:19875-05-9
MF:C5H3Cl3N2
MW:197.449717760086
MDL:MFCD10697352
CID:123817
PubChem ID:12383664
Update Time:2025-10-05

4,6-Dichloro-2-(chloromethyl)pyrimidine Chemical and Physical Properties

Names and Identifiers

    • 4,6-Dichloro-2-(chloromethyl)pyrimidine
    • 2-Chloromethyl-4,6-dichloropyrimidine
    • Pyrimidine,4,6-dichloro-2-(chloromethyl)-
    • 4,6-Dichlor-2-chlormethyl-pyrimidin
    • 4,6-dichloro-2-chloromethyl-pyrimidine
    • QC-9243
    • 4,6-Dichloro-2-(chloromethyl)
    • SCHEMBL379234
    • DTXSID40495618
    • SY103384
    • Pyrimidine, 4,6-dichloro-2-(chloromethyl)-
    • AB59418
    • OGXCXLWVUKSJGE-UHFFFAOYSA-N
    • J-509030
    • 19875-05-9
    • Z1198277455
    • EN300-100333
    • 4,6-dichloro-2-(chloromethyl)pyrimidine? (Dasatinib Impurity pound(c)
    • DS-11363
    • FT-0648469
    • MFCD10697352
    • CS-0164058
    • 4,6-dichloro-2-chloromethylpyrimidine
    • 4 pound not6-Dichloro-2-(chloromethyl)pyrimidine
    • AKOS006305079
    • DB-065978
    • MDL： MFCD10697352
    • Inchi： 1S/C5H3Cl3N2/c6-2-5-9-3(7)1-4(8)10-5/h1H,2H2
    • InChI Key： OGXCXLWVUKSJGE-UHFFFAOYSA-N
    • SMILES： ClCC1N=C(C=C(N=1)Cl)Cl

Computed Properties

  • Exact Mass: 195.93600
  • Monoisotopic Mass: 195.936181g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 10
  • Rotatable Bond Count: 1
  • Complexity: 101
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2.6
  • Topological Polar Surface Area: 25.8?2

Experimental Properties

  • Color/Form: No data available
  • Density: 1.5±0.1 g/cm3
  • Melting Point: No data available
  • Boiling Point: 248.5°C at 760 mmHg
  • Flash Point: 128.2±10.2 °C
  • Refractive Index: 1.572
  • PSA: 25.78000
  • LogP: 2.52220

4,6-Dichloro-2-(chloromethyl)pyrimidine Security Information

4,6-Dichloro-2-(chloromethyl)pyrimidine Customs Data

  • HS CODE：2933599090
  • Customs Data：

    China Customs Code:

    2933599090

    Overview:

    2933599090. Other compounds with pyrimidine ring in structure(Including other compounds with piperazine ring on the structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4,6-Dichloro-2-(chloromethyl)pyrimidine Pricemore >>

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4,6-Dichloro-2-(chloromethyl)pyrimidine Suppliers

Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:19875-05-9)4,6-Dichloro-2-(chloromethyl)pyrimidine
Order Number:A879963
Stock Status:in Stock
Quantity:1g/5g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 10:02
Price ($):237.0/828.0

4,6-Dichloro-2-(chloromethyl)pyrimidine Related Literature

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Additional information on 4,6-Dichloro-2-(chloromethyl)pyrimidine

4,6-Dichloro-2-(chloromethyl)pyrimidine (CAS No. 19875-05-9): A Versatile Building Block in Modern Chemistry

4,6-Dichloro-2-(chloromethyl)pyrimidine (CAS No. 19875-05-9) is a highly valuable intermediate in the field of organic synthesis and pharmaceutical chemistry. This chlorinated pyrimidine derivative has gained significant attention due to its unique reactivity and wide range of applications in the development of biologically active compounds. With the increasing demand for heterocyclic compounds in drug discovery, this chemical has become a crucial building block for researchers worldwide.

The molecular structure of 4,6-Dichloro-2-(chloromethyl)pyrimidine features three reactive chlorine atoms, making it an excellent substrate for nucleophilic substitution reactions. This characteristic has led to its extensive use in the synthesis of various pyrimidine-based pharmaceuticals and agrochemicals. Recent studies in medicinal chemistry have highlighted its importance in creating potential treatments for various diseases, aligning with current healthcare trends and the growing interest in targeted drug development.

In the context of green chemistry and sustainable synthesis, researchers are particularly interested in optimizing reactions involving 4,6-Dichloro-2-(chloromethyl)pyrimidine to minimize environmental impact. This aligns with the increasing focus on eco-friendly chemical processes in the industry. The compound's versatility allows for various modifications, making it a subject of numerous structure-activity relationship studies in drug design.

The global market for pyrimidine derivatives has been expanding steadily, driven by the pharmaceutical industry's need for novel drug candidates. 4,6-Dichloro-2-(chloromethyl)pyrimidine serves as a key intermediate in this market, with its applications extending to the development of antiviral agents, anticancer compounds, and other therapeutic molecules. This trend corresponds with the current surge in research for treatments against emerging diseases and chronic conditions.

From a technical perspective, the synthesis and handling of 4,6-Dichloro-2-(chloromethyl)pyrimidine require specific expertise due to its reactive nature. Researchers often inquire about the optimal reaction conditions for this compound, reflecting the practical challenges in working with such intermediates. The development of novel synthetic methodologies using this building block remains an active area of investigation in academic and industrial laboratories.

Quality control is another critical aspect when working with 4,6-Dichloro-2-(chloromethyl)pyrimidine. Analytical techniques such as HPLC, NMR spectroscopy, and mass spectrometry are commonly employed to ensure the purity and identity of this compound. These analytical considerations are particularly important given the compound's role in producing high-value pharmaceutical intermediates.

The storage and stability of 4,6-Dichloro-2-(chloromethyl)pyrimidine are frequent topics of discussion among chemists. Proper handling under inert atmosphere and storage at controlled temperatures are essential to maintain its reactivity and shelf life. These practical considerations are crucial for researchers looking to incorporate this compound into their synthetic routes effectively.

Recent advancements in computational chemistry have enabled better prediction of the reactivity patterns of 4,6-Dichloro-2-(chloromethyl)pyrimidine. Molecular modeling studies have provided insights into its electronic structure and potential reaction pathways, facilitating more efficient synthetic planning. This integration of computational and experimental approaches represents a modern trend in chemical research.

The patent landscape surrounding pyrimidine derivatives continues to grow, with 4,6-Dichloro-2-(chloromethyl)pyrimidine featuring in numerous intellectual property filings. This reflects the compound's commercial importance and the ongoing innovation in its applications. Companies and research institutions actively monitor these developments to identify new opportunities in drug discovery and material science.

Looking ahead, the demand for 4,6-Dichloro-2-(chloromethyl)pyrimidine is expected to remain strong as researchers explore new therapeutic areas and synthetic applications. Its role in the development of next-generation pharmaceuticals and specialty chemicals ensures its continued relevance in the chemical industry. As synthetic methodologies evolve and new biological targets emerge, this versatile building block will likely maintain its position as a valuable tool for chemists worldwide.

19875-05-9 (4,6-Dichloro-2-(chloromethyl)pyrimidine) Related Products

Recommended suppliers
Amadis Chemical Company Limited
(CAS:19875-05-9)4,6-Dichloro-2-(chloromethyl)pyrimidine
A879963
Purity:99%/99%
Quantity:1g/5g
Price ($):237.0/828.0
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