Production Method 1

50593-91-4

944317-70-8

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride Solvents: Dichloromethane ,  Cyclohexane ;  -60 °C; 30 min, -60 - -15 °C; -15 °C → rt; 12 h, rt; rt → 0 °C
1.2 Reagents: Ammonium chloride Solvents: Water

Reference

Imidazopyrimidine compounds useful for the treatment of cancer and their preparation

, World Intellectual Property Organization, , ,

Production Method 2

79686-05-8

944317-70-8

Reaction Conditions

1.1 Reagents: Lithium borohydride Solvents: Acetonitrile ,  Tetrahydrofuran ;  3 h, < -70 °C; 2 h, -70 °C
1.2 Reagents: Hydrochloric acid Solvents: Water
1.3 Reagents: Sodium carbonate Solvents: Water ;  pH 12

Reference

Preparation of spirocyclic CETP inhibitors

, World Intellectual Property Organization, , ,

Production Method 3

944317-70-8

Reaction Conditions

Reference

Spirocyclic cetp inhibitors

, United States, , ,

Production Method 4

50593-91-4

944317-70-8

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride Solvents: Dichloromethane ,  Cyclohexane ;  -60 °C; 30 min, -60 - -15 °C; -15 °C → rt; 12 h, rt; rt → 0 °C
1.2 Reagents: Ammonium chloride Solvents: Water

Reference

Preparation of imidazopyrimidines as EED inhibitors and the use thereof

, World Intellectual Property Organization, , ,

Production Method 5

50593-91-4

944317-70-8

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride Solvents: Dichloromethane ,  Cyclohexane ;  -60 °C; 30 min, -60 - -15 °C; -15 °C → rt; 12 h, rt; rt → 0 °C
1.2 Reagents: Ammonium chloride Solvents: Water

Reference

EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development

Rej, Rohan Kalyan; Wang, Changwei; Lu, Jianfeng; Wang, Mi; Petrunak, Elyse; et al, Journal of Medicinal Chemistry, 2020, 63(13), 7252-7267

Production Method 6

50593-91-4

944317-70-8

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride Solvents: Dichloromethane ,  Cyclohexane ;  -60 °C; 30 min, -60 - -15 °C; -15 °C → rt; 12 h, rt; rt → 0 °C
1.2 Reagents: Ammonium chloride Solvents: Water

Reference

Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy

Huang, Ying ; Zhang, Jeff; Yu, Zhengtian; Zhang, Hailong; Wang, Youzhen; et al, Journal of Medicinal Chemistry, 2017, 60(6), 2215-2226

Production Method 7

79686-05-8

944317-70-8

Reaction Conditions

1.1 Reagents: Lithium borohydride

Reference

Preparation of phenylazetidinylpyrimidinylmethyloxazolidinone derivatives and analogs for use as CETP inhibitors

, World Intellectual Property Organization, , ,

Production Method 8

50593-91-4

944317-70-8

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride Solvents: Tetrahydrofuran ;  -10 - 0 °C; < 0 °C
1.2 Reagents: Ammonium chloride Solvents: Water

Reference

Oxazolidinone derivatives as CETP inhibitors and their preparation, pharmaceutical compositions and use in the treatment of atherosclerosis, raising HDL-cholesterol and lowering LDL-cholesterol

, World Intellectual Property Organization, , ,

[5-bromo-2-(methylsulfanyl)pyrimidin-4-yl]methanol Raw materials

• methyl 5-bromo-2-(methylsulfanyl)pyrimidine-4-carboxylate
• 5-bromo-2-methylthiopyrimidine-4-carbonyl chloride

[5-bromo-2-(methylsulfanyl)pyrimidin-4-yl]methanol Preparation Products

• [5-bromo-2-(methylsulfanyl)pyrimidin-4-yl]methanol (944317-70-8)

• 1. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 2. An approach for correlating the structural and electrical properties of Zr4+-modified SrBi4Ti4O15/SBT ceramic
  Priyambada Nayak,Tanmaya Badapanda,Anil Kumar Singh,Simanchalo Panigrahi RSC Adv., 2017,7, 16319-16331
• 3. An aquatic host–guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin?
  José M. Rivera,Mariana Martín-Hidalgo,Jean C. Rivera-Ríos Org. Biomol. Chem., 2012,10, 7562-7565
• 4. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 5. An autonomous self-optimizing flow machine for the synthesis of pyridine–oxazoline (PyOX) ligands?
  Eric Wimmer,Daniel Cortés-Borda,Solène Brochard,Elvina Barré,Charlotte Truchet,Fran?ois-Xavier Felpin React. Chem. Eng., 2019,4, 1608-1615

Comprehensive Guide to [5-bromo-2-(methylsulfanyl)pyrimidin-4-yl]methanol (CAS No. 944317-70-8): Properties, Applications, and Market Insights

[5-bromo-2-(methylsulfanyl)pyrimidin-4-yl]methanol (CAS No. 944317-70-8) is a specialized pyrimidine derivative with significant potential in pharmaceutical and agrochemical research. This compound, featuring a bromine substituent and a methylsulfanyl group, has garnered attention for its unique chemical properties and versatility in synthetic applications. Researchers and industry professionals are increasingly exploring its role in drug discovery and material science, aligning with current trends in small molecule therapeutics and heterocyclic chemistry.

The molecular structure of [5-bromo-2-(methylsulfanyl)pyrimidin-4-yl]methanol offers excellent opportunities for further functionalization, making it a valuable building block in organic synthesis. Its pyrimidine core is particularly relevant in the development of kinase inhibitors and antiviral agents, addressing growing demands in precision medicine. Recent studies highlight its potential in addressing challenges posed by drug-resistant pathogens, a hot topic in pharmaceutical research.

From a commercial perspective, the global market for pyrimidine derivatives like [5-bromo-2-(methylsulfanyl)pyrimidin-4-yl]methanol is expanding rapidly, driven by increased R&D investment in targeted therapies. The compound's CAS No. 944317-70-8 serves as a crucial identifier for procurement and regulatory compliance, especially in regions with strict chemical substance tracking requirements. Suppliers are noting growing inquiries about this specific brominated pyrimidine, reflecting its rising importance in specialty chemical sectors.

In synthetic applications, the hydroxymethyl group of [5-bromo-2-(methylsulfanyl)pyrimidin-4-yl]methanol provides an excellent handle for further modifications, enabling the creation of diverse molecular architectures. This characteristic aligns well with current industry needs for modular synthesis approaches in drug discovery. The compound's methylsulfanyl moiety also offers unique reactivity patterns that are being explored in catalysis research and materials science applications.

Quality control and characterization of [5-bromo-2-(methylsulfanyl)pyrimidin-4-yl]methanol typically involve advanced analytical techniques such as HPLC, NMR spectroscopy, and mass spectrometry. These methods ensure the compound meets the stringent purity requirements for pharmaceutical intermediates, a critical factor given the current emphasis on process chemistry optimization. The bromine atom in the structure provides a distinct spectroscopic signature that facilitates precise identification and quantification.

Environmental and handling considerations for CAS No. 944317-70-8 follow standard laboratory safety protocols for organobromine compounds. While not classified as hazardous under normal conditions, proper storage in ambient temperature conditions with protection from moisture is recommended to maintain stability. These handling requirements are similar to those for many pharmaceutical intermediates currently in development pipelines worldwide.

The future outlook for [5-bromo-2-(methylsulfanyl)pyrimidin-4-yl]methanol appears promising, particularly in light of increasing interest in structure-activity relationship studies for medicinal chemistry applications. Its combination of hydrogen bond donor/acceptor properties and lipophilic character makes it particularly interesting for bioavailability optimization research. These attributes position it well within current pharmaceutical industry trends toward fragment-based drug design.

For researchers seeking high-purity [5-bromo-2-(methylsulfanyl)pyrimidin-4-yl]methanol, several specialty chemical suppliers offer the compound with detailed certificates of analysis. The availability of custom synthesis services for this pyrimidine derivative has increased significantly in recent years, reflecting its growing importance in drug discovery platforms. Current pricing trends indicate stable demand for this research chemical across academic and industrial laboratories.

In conclusion, [5-bromo-2-(methylsulfanyl)pyrimidin-4-yl]methanol (CAS No. 944317-70-8) represents an important chemical building block with diverse applications in modern chemistry. Its unique structural features and synthetic versatility make it valuable for addressing current challenges in medicinal chemistry and material science. As research continues to explore the full potential of pyrimidine-based compounds, this particular derivative is likely to maintain its relevance in cutting-edge scientific developments.

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