Production Method 1

943-15-7

Reaction Conditions

1.1 Reagents: Boron, (dinitrogen tetraoxide-O)trifluoro-, (T-4)- Solvents: Carbon tetrachloride

Reference

The boron trifluoride-dinitrogen tetroxide complex as a nitrating agent

Bachman, G. Bryant; Vogt, Clifford M., Journal of the American Chemical Society, 1958, 80, 2987-91

Production Method 2

943-15-7

Reaction Conditions

Reference

Nitration of p-cymene. Exchange and rearomatization reactions of p-cymene adducts

Fischer, Alfred; Roderer, Rolf, Canadian Journal of Chemistry, 1976, 54(3), 423-8

Production Method 3

943-15-7

Reaction Conditions

Reference

Ipso nitration. II. Novel products and true positional selectivities in nitration of p-cymene

Hahn, Roger C.; Strack, David L., Journal of the American Chemical Society, 1974, 96(13), 4335-7

Production Method 4

52834-93-2

943-15-7

127420-18-2

127368-12-1

127368-10-9

118297-28-2

127420-20-6

Reaction Conditions

1.1 Reagents: Nitrogen dioxide Solvents: Acetic anhydride

Reference

Reactions of 4-methyl-1-(1'-methylethyl)-4-nitrocyclohexa-2,5-dien-1-yl acetates with nitrogen dioxide; towards a mechanism for the formation of polynitro cyclohexenyl esters on reaction of p-cymene with nitrogen dioxide in acetic anhydride

Abell, Andrew D.; Hartshorn, Michael P.; Robinson, Ward T.; Waller, A. Grant; Wright, Graeme J., Australian Journal of Chemistry, 1989, 42(12), 2225-42

Production Method 5

943-15-7

118297-28-2

Reaction Conditions

1.1 Reagents: Nitrogen dioxide Solvents: Acetic anhydride

Reference

The nitration of p-cymene with nitrogen dioxide in acetic anhydride: the isolation and x-ray structure determination of 6-methyl-3-(methylethyl)-t-5-nitrato-1,r-3,c-4,t-6-tetranitrocyclohexene

Hartshorn, Michael P.; Robinson, Ward T.; Waller, A. Grant; Wright, Graeme J., Tetrahedron Letters, 1988, 29(16), 1999-2000

Production Method 6

943-15-7

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Nitric acid Solvents: Acetic acid

Reference

2-Nitro-p-cymene

Kobe, Kenneth A.; Doumani, Thomas F., Organic Syntheses, 1941, 21, 96-8

Production Method 7

943-15-7

Reaction Conditions

1.1 Reagents: Acetic acid ,  Sulfuric acid ,  Nitric acid ;  -15 °C; -15 °C; -15 °C → 0 °C; 0 °C; 0 °C; 1 h, 0 °C
1.2 Reagents: Water ;  1 h, cooled

Reference

Bio-based hydrophobic epoxy-amine networks derived from renewable terpenoids

Garrison, Michael D.; Harvey, Benjamin G., Journal of Applied Polymer Science, 2016, 133(45),

Production Method 8

943-15-7

Reaction Conditions

Reference

Nitroarenes

Aitken, K. M.; Aitken, R. A., Science of Synthesis, 2007, 31, 1183-1320

Production Method 9

943-15-7

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Nitric acid

Reference

Mononitration of p-cymene

Kobe, Kenneth A.; Langworthy, Eugene M., Industrial and Engineering Chemistry, 1957, 49, 801-6

Production Method 10

943-15-7

Reaction Conditions

Reference

"Ipso" Aromatic Nitration in the Gas Phase

Attina, M.; Cacace, F.; Ricci, A., Journal of Physical Chemistry, 1996, 100(11), 4424-9

Production Method 11

943-15-7

Reaction Conditions

Reference

Nitration of aromatic hydrocarbons and ipso-nitrosodemetalation of arylmetal compounds in sodium nitrite-trifluoroacetic acid

Uemura, Sakae; Toshimitsu, Akio; Okano, Masaya, Journal of the Chemical Society, 1978, (9), 1076-9

Production Method 12

943-15-7

Reaction Conditions

Reference

New examples in the use of graphite bisulfate and graphite nitrate in organic synthesis

Alazard, J. P.; Kagan, H. B.; Setton, R., Bulletin de la Societe Chimique de France, 1977, 499, 499-504

Production Method 13

943-15-7

35480-94-5

Reaction Conditions

Reference

Aromatic substitution. XX. Intact and dealkylating nitration of propylated and butylated alkylbenzenes with nitronium tetrafluoroborate

Olah, George A.; Kuhn, Stephen J., Journal of the American Chemical Society, 1964, (6), 1067-70

Production Method 14

943-15-7

127368-12-1

118297-28-2

127420-20-6

Reaction Conditions

1.1 Reagents: Nitrogen dioxide Solvents: Acetic anhydride

Reference

The nitration of p-cymene with nitrogen dioxide in acetic anhydride

Hartshorn, Michael P.; Robinson, Ward T.; Waller, A. Grant; Wright, Graeme J., Australian Journal of Chemistry, 1989, 42(12), 2143-60

2-Nitro-4-cymene Raw materials

• 2,5-Cyclohexadien-1-ol, 4-methyl-1-(1-methylethyl)-4-nitro-, acetate (ester), trans- (9CI)

2-Nitro-4-cymene Preparation Products

• 2-Nitro-4-cymene (943-15-7)
• 3-Cyclohexen-1-ol, 2-methyl-5-(1-methylethyl)-2,3,5,6-tetranitro-, nitrate (ester), (1α,2α,5α,6β)- (127420-18-2)
• 4-Cyclohexene-1,3-diol, 2-methyl-5-(1-methylethyl)-2,6-dinitro-, 1-nitrate, (1α,2α,3α,6β)- (127368-12-1)
• 3-Cyclohexen-1-ol, 2-methyl-5-(1-methylethyl)-2,5,6-trinitro-, nitrate (ester), (1α,2α,5β,6β)- (127368-10-9)
• (118297-28-2)
•   (35480-94-5)
• 4-Cyclohexene-1,3-diol, 2-methyl-5-(1-methylethyl)-2,6-dinitro-, 1-nitrate, (1α,2α,3β,6β)- (127420-20-6)

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• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Prenol lipids Aromatic monoterpenoids
• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Prenol lipids Monoterpenoids Aromatic monoterpenoids
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

• 10482-00-5(Benzene, 1,4-diethyl-2-nitro-)
• 62559-42-6(4-ethyl-1-methyl-2-nitrobenzene)
• 62559-41-5(Benzene, 1-ethyl-4-methyl-2-nitro-)
• 3463-35-2(2,5-Di-tert-butylnitrobenzene)
• 6279-89-6(5-tert-Butyl-1,3-dimethyl-2-nitro-benzene)
• 62559-08-4(4-tert-Butyl-1-methyl-2-nitrobenzene)
• 4162-89-4(5-tert-butyl-2-methyl-1,3-dinitrobenzene)
• 6526-72-3(2-Nitrocumene)
• 35480-94-5( )
• 10472-73-8(Benzene, 2,5-bis(1,1-dimethylethyl)-1,3-dinitro-)