Production Method 1

19798-80-2

942947-94-6

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile ;  rt; 16 h, rt

Reference

Preparation of oxodihydropyridine derivatives and analogs for use as bromodomain inhibitors

, World Intellectual Property Organization, , ,

Production Method 2

19798-80-2

942947-94-6

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile ;  rt; 14 h, rt

Reference

Preparation of aryl lactam kinase inhibitors useful in inhibiting AAK1

, United States, , ,

Production Method 3

19798-80-2

942947-94-6

Reaction Conditions

1.1 Reagents: Acetic acid Solvents: Tetrahydrofuran ;  rt → 0 °C
1.2 Reagents: N-Bromosuccinimide Solvents: Tetrahydrofuran ;  1.5 h, 0 - 10 °C; 2 h, 0 - 10 °C
1.3 Reagents: Sodium hydroxide Solvents: Toluene ,  Water

Reference

Processe to make protein kinase inhibitor N-[4-[4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl]phenyl]-N'-(3-fluorophenyl)urea

, World Intellectual Property Organization, , ,

Production Method 4

19798-80-2

942947-94-6

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Dichloromethane ;  0 °C; 30 min

Reference

A process for preparing 5-bromo-2,4-dichloro-pyridine from 4-chloro-2-pyridinamine

, China, , ,

Production Method 5

19798-80-2

942947-94-6

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile ;  6 h, rt

Reference

Synthesis of Hpk1 degrader anticancer agents

, World Intellectual Property Organization, , ,

Production Method 6

19798-80-2

942947-94-6

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile ;  3 h, rt

Reference

Preparation of 2-aminopyridine compounds useful in treating hyperproliferative diseases

, World Intellectual Property Organization, , ,

Production Method 7

19798-80-2

942947-94-6

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile ;  rt; 16 h, rt

Reference

Imidazo[4,5-b]pyridine Derivatives As Inhibitors of Aurora Kinases: Lead Optimization Studies toward the Identification of an Orally Bioavailable Preclinical Development Candidate

Bavetsias, Vassilios; Large, Jonathan M.; Sun, Chongbo; Bouloc, Nathalie; Kosmopoulou, Magda; et al, Journal of Medicinal Chemistry, 2010, 53(14), 5213-5228

Production Method 8

19798-80-2

942947-94-6

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile ;  rt; 16 h, rt

Reference

Preparation of imidazopyridines as enzyme inhibitors, especially Aurora kinase inhibitors, for treating cell proliferative diseases

, World Intellectual Property Organization, , ,

Production Method 9

19798-80-2

942947-94-6

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile ;  12 h, rt

Reference

Imidazopyridine derivative and pharmaceutical composition comprising same as active ingredient

, Korea, , ,

Production Method 10

19798-80-2

942947-94-6

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile ;  rt; 14 h, rt

Reference

Preparation of chromenopyridine derivatives for use as adaptor associated kinase 1 inhibitors

, World Intellectual Property Organization, , ,

Production Method 11

19798-80-2

942947-94-6

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile ;  14 h, rt

Reference

Preparation of chromenopyridinyloxyalkylamine derivatives for use as adaptor associated kinase 1 inhibitors

, World Intellectual Property Organization, , ,

Production Method 12

19798-80-2

942947-94-6

Reaction Conditions

1.1 Reagents: Tetrabutylammonium bromide ,  Lithium perchlorate Solvents: Acetic acid ,  Acetonitrile ;  16 h, 25 °C

Reference

Electrochemical synthesis method of bromopyridine derivatives

, China, , ,

Production Method 13

19798-80-2

942947-94-6

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile ;  3 h, rt

Reference

Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19

Mallinger, Aurelie; Schiemann, Kai; Rink, Christian; Stieber, Frank; Calderini, Michel; et al, Journal of Medicinal Chemistry, 2016, 59(3), 1078-1101

Production Method 14

19798-80-2

942947-94-6

Reaction Conditions

1.1 Reagents: Bromine Solvents: Acetonitrile ;  30 min, 0 °C; 0 °C → rt; overnight, rt

Reference

Tricyclic pyridocarboxamide derivatives as ROCK inhibitors and their preparation

, World Intellectual Property Organization, , ,

Production Method 15

19798-80-2

942947-94-6

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile

Reference

Imidazo[1,2-a]pyridine compounds as tyrosine kinase c-Met signal transduction pathway inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cell hyperplasia diseases

, World Intellectual Property Organization, , ,

Production Method 16

19798-80-2

942947-94-6

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile

Reference

Preparation of chromenopyridine derivatives for use as AAK1 inhibitors

, World Intellectual Property Organization, , ,

Production Method 17

19798-80-2

942947-94-6

Reaction Conditions

1.1 Reagents: Tetrabutylammonium bromide ,  Lithium perchlorate Solvents: Acetic acid ,  Acetonitrile ;  8 h, 25 °C

Reference

Directing Group Enables Electrochemical Selectively Meta-Bromination of Pyridines under Mild Conditions

Wu, Yanwei; Xu, Shanghui; Wang, Hong; Shao, Dongxu; Qi, Qiqi; et al, Journal of Organic Chemistry, 2021, 86(22), 16144-16150

5-Bromo-4-chloropyridin-2-amine Raw materials

• 4-Chloro-pyridin-2-ylamine

5-Bromo-4-chloropyridin-2-amine Preparation Products

• 5-Bromo-4-chloropyridin-2-amine (942947-94-6)

• 1. Distinguishing between polymorphic forms of linezolid by solid-phase electronic and vibrational circular dichroism?
  Jadwiga Frelek,Marcin Górecki,Marta ?aszcz,Agata Suszczyńska,Elemér Vass,Wojciech J. Szczepek Chem. Commun., 2012,48, 5295-5297
• 2. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
• 3. Fe3O4/PEG-SO3H as a heterogeneous and magnetically-recyclable nanocatalyst for the oxidation of sulfides to sulfones or sulfoxides
  Saeideh Mirfakhraei,Malak Hekmati,Fereshteh Hosseini Eshbala,Hojat Veisi New J. Chem., 2018,42, 1757-1761
• 4. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 5. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines Polyhalopyridines

• 1131604-99-3(5-Bromo-4-chloropyridine-2,3-diamine)
• 1823969-53-4(5-Bromo-4-chloro-N,N-dimethylpyridin-2-amine)
• 1242329-23-2(3,5-dibromo-4-chloropyridin-2-amine)
• 917969-29-0(Pyridine, 3-bromo-4-chloro-2-hydrazinyl-)
• 1607837-98-8(5-Bromo-3,4-dichloropyridin-2-amine)
• 221297-82-1(3-Bromo-4-chloropyridin-2-amine)
• 2256740-10-8(5-bromo-4-chloropyridin-3,6-d2-2-amine)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)