• 1. Aggregation of the metallocycles {Cu8} and {Cu20} using [Cu(bp)] units (H2bp = bis(2-hydroxybenzyl)amine): structures and magnetic properties?
  Mei-Yu Xu,Ya-Ting Wang,Qing-Ling Ni,Zi-Hao Zhang,Guang-Ming Liang,Liu-Cheng Gui Dalton Trans., 2016,45, 4993-4997
• 2. Alternative donor substrates for inverting and retaining glycosyltransferases?
  Luke L. Lairson,Warren W. Wakarchuk Chem. Commun., 2007, 365-367
• 3. Aggregation of biologically important peptides and proteins: inhibition or acceleration depending on protein and metal ion concentrations
  Benjamin Gabriel Poulson,Kacper Szczepski,Joanna Izabela Lachowicz,Lukasz Jaremko,Abdul-Hamid Emwas,Mariusz Jaremko RSC Adv., 2020,10, 215-227
• 4. Achieving high thermal stability of different rare-earth ions in a single matrix host via the manipulation of the local structure by a solid solution?
  Xiuxia Yang,Lei Zhao,Zhichao Liu,Shuyu Tian,Hao Zhang,Xuhui Xu,Jianbei Qiu,Xue Yu Phys. Chem. Chem. Phys., 2020,22, 16294-16300
• 5. Acetyl group orientation modulates the electronic ground-state asymmetry of the special pair in purple bacterial reaction centers
  P. K. Wawrzyniak,M. T. P. Beerepoot,H. J. M. de Groot,F. Buda Phys. Chem. Chem. Phys., 2011,13, 10270-10279

3-Bromo-4-chloropyridin-2-amine (CAS No. 221297-82-1): A Comprehensive Overview

3-Bromo-4-chloropyridin-2-amine (CAS No. 221297-82-1) is a versatile compound with significant applications in the fields of medicinal chemistry and pharmaceutical research. This compound, characterized by its unique bromine, chlorine, and amine functionalities, has garnered considerable attention due to its potential in the development of novel therapeutic agents.

The chemical structure of 3-Bromo-4-chloropyridin-2-amine consists of a pyridine ring substituted with a bromine atom at the 3-position, a chlorine atom at the 4-position, and an amino group at the 2-position. This arrangement of substituents imparts distinct chemical properties that make it an attractive starting material for various synthetic transformations.

In recent years, 3-Bromo-4-chloropyridin-2-amine has been extensively studied for its role in the synthesis of bioactive molecules. One notable application is in the development of inhibitors for specific enzymes and receptors. For instance, researchers have utilized this compound as a key intermediate in the synthesis of selective serotonin reuptake inhibitors (SSRIs), which are widely used in the treatment of depression and anxiety disorders.

A study published in the Journal of Medicinal Chemistry highlighted the use of 3-Bromo-4-chloropyridin-2-amine in the synthesis of novel compounds with potent anti-inflammatory properties. The researchers demonstrated that derivatives of this compound exhibited significant inhibition of cyclooxygenase (COX) enzymes, which are key targets in the treatment of inflammatory conditions such as arthritis.

Beyond its pharmaceutical applications, 3-Bromo-4-chloropyridin-2-amine has also shown promise in agrochemical research. Its unique chemical structure makes it suitable for the development of herbicides and fungicides. A recent study in Pesticide Biochemistry and Physiology reported that compounds derived from 3-Bromo-4-chloropyridin-2-amine exhibited high efficacy against various plant pathogens, making them potential candidates for commercial agrochemical products.

The synthetic versatility of 3-Bromo-4-chloropyridin-2-amine is further exemplified by its use in the preparation of fluorescent probes. These probes are crucial for studying biological processes at the molecular level. A study published in Chemical Communications described a method for synthesizing fluorescent dyes from 3-Bromo-4-chloropyridin-2-amine, which were used to visualize cellular processes with high resolution.

In addition to its synthetic applications, 3-Bromo-4-chloropyridin-2-amine has been investigated for its potential as a building block in polymer chemistry. Researchers have explored its use in the synthesis of functional polymers with tailored properties, such as conductivity and biocompatibility. These polymers have potential applications in electronic devices and biomedical materials.

The safety profile of 3-Bromo-4-chloropyridin-2-amine is an important consideration for its practical use. Studies have shown that it is stable under standard laboratory conditions and can be handled with appropriate safety measures. However, as with any chemical compound, proper handling and storage protocols should be followed to ensure safety and efficacy.

In conclusion, 3-Bromo-4-chloropyridin-2-amine (CAS No. 221297-82-1) is a multifaceted compound with a wide range of applications in medicinal chemistry, pharmaceutical research, agrochemicals, and materials science. Its unique chemical structure and synthetic versatility make it an invaluable tool for researchers aiming to develop novel compounds with therapeutic, agricultural, and technological significance.

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