Cas no 942473-59-8 (2,5-dibromopyridine-4-carboxylic acid)

2,5-Dibromopyridine-4-carboxylic acid is a brominated pyridine derivative with a carboxylic acid functional group at the 4-position. This compound serves as a versatile intermediate in organic synthesis, particularly in pharmaceutical and agrochemical applications. The presence of bromine atoms at the 2- and 5-positions enhances its reactivity in cross-coupling reactions, such as Suzuki or Stille couplings, enabling the construction of complex heterocyclic frameworks. The carboxylic acid moiety further allows for derivatization via esterification, amidation, or other functional group transformations. Its high purity and well-defined structure make it a reliable building block for research and industrial processes requiring precise molecular modifications.
2,5-dibromopyridine-4-carboxylic acid structure
942473-59-8 structure
Product Name:2,5-dibromopyridine-4-carboxylic acid
CAS No:942473-59-8
MF:C6H3Br2NO2
MW:280.901520013809
MDL:MFCD08741485
CID:858021
PubChem ID:26343696
Update Time:2025-06-08

2,5-dibromopyridine-4-carboxylic acid Chemical and Physical Properties

Names and Identifiers

    • 2,5-Dibromoisonicotinic acid
    • 2,5-DIBROMO-ISONICOTINIC ACID
    • 2,5-Dibromopyridine-4-carboxylic acid
    • 4-Pyridinecarboxylic acid,2,5-dibromo-
    • 2,5-Dibromo-isonicotinicacid
    • PubChem11161
    • 2,5-DIBROMO-4-PYRIDINECARBOXYLIC ACID
    • CLIZDLYBXIPXCR-UHFFFAOYSA-N
    • BBL103443
    • 2,5-BIBROMOISONICOTINIC ACID
    • STL557253
    • SBB065031
    • AB48781
    • VP10927
    • AB0037493
    • ST24038710
    • Y4779
    • B-
    • 2,5-Dibromo-4-pyridinecarboxylic acid (ACI)
    • 2,5-dibromopyridine-4-carboxylic acid
    • MDL： MFCD08741485
    • Inchi： 1S/C6H3Br2NO2/c7-4-2-9-5(8)1-3(4)6(10)11/h1-2H,(H,10,11)
    • InChI Key： CLIZDLYBXIPXCR-UHFFFAOYSA-N
    • SMILES： O=C(C1C(Br)=CN=C(Br)C=1)O

Computed Properties

  • Exact Mass: 278.85300
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 1
  • Complexity: 165
  • Topological Polar Surface Area: 50.2

Experimental Properties

  • PSA: 50.19000
  • LogP: 2.30480

2,5-dibromopyridine-4-carboxylic acid Security Information

  • HazardClass：IRRITANT

2,5-dibromopyridine-4-carboxylic acid Customs Data

  • HS CODE：2933399090
  • Customs Data：

    China Customs Code:

    2933399090

    Overview:

    2933399090. Other compounds with non fused pyridine rings in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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2,5-dibromopyridine-4-carboxylic acid Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ;  1 h, -80 °C; 30 min, -70 °C
1.2 -70 °C; 30 min, -70 °C
1.3 Reagents: Water ;  -70 °C
1.4 Reagents: Hydrochloric acid Solvents: Water ;  pH 3 - 4
Reference
Preparation of naphthyridines and isoquinolines as serine/threonine kinase inhibitors for the treatment of hyperproliferative diseases
, World Intellectual Property Organization, , ,

2,5-dibromopyridine-4-carboxylic acid Raw materials

2,5-dibromopyridine-4-carboxylic acid Preparation Products

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