- Preparation of pyrrolo[2,3-b]pyridines as inhibitors of kinases for the treatment of cancer, United States, , ,
Cas no 940948-31-2 (1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-iodo-1-[(2-iodophenyl)sulfonyl]-)
![1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-iodo-1-[(2-iodophenyl)sulfonyl]- structure](https://ossimg.kuujia.com/scimg/941000/940948-31-2x500.png)
940948-31-2 structure
Product Name:1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-iodo-1-[(2-iodophenyl)sulfonyl]-
CAS No:940948-31-2
MF:C13H7ClI2N2O2S
MW:544.533825159073
CID:5688546
Update Time:2023-09-27
1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-iodo-1-[(2-iodophenyl)sulfonyl]- Chemical and Physical Properties
Names and Identifiers
-
- 1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-iodo-1-[(2-iodophenyl)sulfonyl]-
-
- Inchi： 1S/C13H7ClI2N2O2S/c14-9-5-6-17-13-8(9)7-12(16)18(13)21(19,20)11-4-2-1-3-10(11)15/h1-7H
- InChI Key： PWONECZCBCBPEO-UHFFFAOYSA-N
- SMILES： C12N(S(C3=CC=CC=C3I)(=O)=O)C(I)=CC1=C(Cl)C=CN=2
Experimental Properties
- Density: 2.30±0.1 g/cm3(Predicted)
- Boiling Point: 593.8±60.0 °C(Predicted)
- pka: 0.79±0.30(Predicted)
1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-iodo-1-[(2-iodophenyl)sulfonyl]- Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ; 30 min, -78 °C
1.2 Reagents: Iodine Solvents: Tetrahydrofuran ; 4 h, -78 °C
1.3 Reagents: Sodium thiosulfate Solvents: Water
1.2 Reagents: Iodine Solvents: Tetrahydrofuran ; 4 h, -78 °C
1.3 Reagents: Sodium thiosulfate Solvents: Water
Reference
1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-iodo-1-[(2-iodophenyl)sulfonyl]- Raw materials
1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-iodo-1-[(2-iodophenyl)sulfonyl]- Preparation Products
1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-iodo-1-[(2-iodophenyl)sulfonyl]- Related Literature
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Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873
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José M. Rivera,Mariana Martín-Hidalgo,Jean C. Rivera-Ríos Org. Biomol. Chem., 2012,10, 7562-7565
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Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043
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Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
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Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789
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