Production Method 1

80-48-8

94057-02-0

94055-75-1

16722-51-3

Reaction Conditions

1.1 Solvents: Acetone ;  10 h, reflux; 3 h, cooled

Reference

Synthesis of suplatast tosilate

Li, Chungang; Liu, Ying; Liu, Yanmin; Jia, Zheng; Dong, Zhuo, Guangdong Yaoxueyuan Xuebao, 2009, 25(3), 278-280

Production Method 2

80-48-8

94057-02-0

94055-75-1

16722-51-3

Reaction Conditions

1.1 Solvents: Dichloromethane ;  24 h, 50 °C

Reference

Improved process for preparing suplatast tosilate

Li, Zhiyu; Lu, Pingbo; Mo, Fenzhu; You, Qidong, Zhongguo Yaowu Huaxue Zazhi, 2009, 19(1), 45-47

Production Method 3

94055-75-1

16722-51-3

Reaction Conditions

Reference

Preparation of suplatast tosilate crystals

, World Intellectual Property Organization, , ,

Production Method 4

94055-75-1

16722-51-3

Reaction Conditions

Reference

Ideal enantiomeric resolution by recrystallization of a racemic compound (part 4): relationship between enantiomeric resolution phenomenon and crystal properties

Tamura, Rui; Ushio, Takanori; Takahashi, Hiroki; Nakamura, Kimitaka; Azuma, Nagao; et al, Chirality, 1997, 9(3), 220-224

Production Method 5

80-48-8

94057-02-0

94055-75-1

16722-51-3

Reaction Conditions

1.1 20 °C → 60 °C; 20 - 24 h, 50 - 60 °C

Reference

Preparation method of Suplatast tosilate and its intermediates

, China, , ,

Production Method 6

16722-51-3

44743-29-5

94056-98-1

94055-75-1

16722-51-3

Reaction Conditions

1.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Acetone ;  2 h, 20 - 30 °C
1.2 4 h, 20 - 30 °C

Reference

Method for preparing suplatast tosylate

, China, , ,

Production Method 7

94055-75-1

16722-51-3

Reaction Conditions

Reference

Method of evaluating evenness of suplatast tosylate crystal, even crystal, and process for producing the same

, World Intellectual Property Organization, , ,

Production Method 8

94055-75-1

16722-51-3

Reaction Conditions

Reference

Synthesis and Antiallergic Activity of Dimethyl-2-(phenylcarbamoyl)ethylsulfonium p-Toluenesulfonate Derivatives

Tada, Yukio; Yamawaki, Ichiro; Ueda, Shuichi; Matsumoto, Hiroshi; Matsuura, Naosuke; et al, Journal of Medicinal Chemistry, 1998, 41(18), 3330-3336

Production Method 9

94055-75-1

16722-51-3

Reaction Conditions

Reference

Sulfonium compounds and pharmaceuticals containing them

, Federal Republic of Germany, , ,

Sulfonium, [3-[[4-(3-ethoxy-2-hydroxypropoxy)phenyl]amino]-3-oxopropyl]dimethyl- Raw materials

• Benzenesulfonic acid,4-methyl-, ion(1-)
• methyl 4-methylbenzene-1-sulfonate
• 3-dimethylsulfonio-propionic acid cation
• 4-(3-Ethoxy-2-hydroxypropoxy)aniline
• N-[4-(3-Ethoxy-2-hydroxypropoxy)phenyl]-3-(methylthio)propanamide

Sulfonium, [3-[[4-(3-ethoxy-2-hydroxypropoxy)phenyl]amino]-3-oxopropyl]dimethyl- Preparation Products

• Sulfonium, [3-[[4-(3-ethoxy-2-hydroxypropoxy)phenyl]amino]-3-oxopropyl]dimethyl- (94055-75-1)
• Benzenesulfonic acid,4-methyl-, ion(1-) (16722-51-3)

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