Production Method 1

660-49-1

939771-60-5

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Water ;  4.5 h, rt → 90 °C; cooled
1.2 Reagents: Sodium nitrite Solvents: Water ;  0 °C; 0 °C → rt
1.3 Reagents: Sulfuric acid Solvents: Water ;  rt → 90 °C; 1 h, 90 °C; overnight, cooled

Reference

Preparation of 8-azabicyclo[3.2.1]octane derivatives useful as mono-amine reuptake inhibitors

, World Intellectual Property Organization, , ,

Production Method 2

1167056-58-7

939771-60-5

Reaction Conditions

1.1 Reagents: Boron tribromide Solvents: Dichloromethane ;  1 h, -78 °C; -78 °C → rt; 12 h, rt
1.2 Solvents: Methanol ;  rt

Reference

Efficient Discovery of Potent Anti-HIV Agents Targeting the Tyr181Cys Variant of HIV Reverse Transcriptase

Jorgensen, William L.; Bollini, Mariela; Thakur, Vinay V.; Domaoal, Robert A.; Spasov, Krasimir A.; et al, Journal of the American Chemical Society, 2011, 133(39), 15686-15696

Production Method 3

660-49-1

939771-60-5

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Water ;  4.5 h, rt → 90 °C
1.2 Reagents: Sodium nitrite Solvents: Water ;  0 °C; 0 °C → rt; rt → 90 °C; 1 h, 90 °C; overnight, cooled

Reference

Preparation of 8-azabicyclo[3.2.1]octane derivatives as monoamine neurotransmitter reuptake inhibitors

, United States, , ,

3-Fluoro-5-iodophenol Raw materials

• 1-Fluoro-3-iodo-5-methoxy-benzene
• 3-Fluoro-5-iodoaniline

3-Fluoro-5-iodophenol Preparation Products

• 3-Fluoro-5-iodophenol (939771-60-5)

• 1. Enabling stable MnO2 matrix for aqueous zinc-ion battery cathodes?
  Yiding Jiao,Liqun Kang,Jasper Berry-Gair,Kit McColl,Jianwei Li,Haobo Dong,Hao Jiang,Ryan Wang,Furio Corà,Dan J. L. Brett,Ivan P. Parkin J. Mater. Chem. A, 2020,8, 22075-22082
• 2. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 3. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538
• 4. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 5. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenols Halophenols Iodophenols

Comprehensive Overview of 3-Fluoro-5-iodophenol (CAS No. 939771-60-5): Properties, Applications, and Industry Trends

3-Fluoro-5-iodophenol (CAS No. 939771-60-5) is a halogenated phenol derivative that has garnered significant attention in pharmaceutical and agrochemical research due to its unique structural properties. This compound, characterized by the presence of both fluorine and iodine substituents on the aromatic ring, serves as a versatile intermediate in organic synthesis. Its molecular formula, C₆H₄FIO, and molecular weight of 238.00 g/mol make it a valuable building block for designing complex molecules.

In recent years, the demand for halogenated phenols like 3-Fluoro-5-iodophenol has surged, driven by their applications in drug discovery and material science. Researchers frequently search for "3-Fluoro-5-iodophenol synthesis" or "CAS 939771-60-5 applications," reflecting its relevance in modern chemistry. The compound's ability to undergo cross-coupling reactions, such as Suzuki or Ullmann couplings, positions it as a critical component in creating biologically active molecules.

One of the most discussed topics in 2024 is the role of fluorinated compounds in medicinal chemistry. 3-Fluoro-5-iodophenol aligns with this trend, as the fluorine atom enhances metabolic stability and bioavailability in drug candidates. Its iodo group further allows for late-stage functionalization, a technique highly sought after in fragment-based drug design. These attributes explain why queries like "fluorophenol derivatives in drug development" are trending in scientific databases.

From an industrial perspective, 939771-60-5 is often utilized in the production of liquid crystal materials and organic electronic components. Its incorporation into polymers improves thermal stability and optoelectronic properties, addressing the growing need for advanced materials in renewable energy technologies. Searches for "iodophenol-based liquid crystals" or "halogenated aromatics for OLEDs" highlight these niche applications.

Environmental and safety considerations are also pivotal in discussions about 3-Fluoro-5-iodophenol. While not classified as hazardous under standard regulations, proper handling protocols are emphasized in literature. The compound's biodegradability and eco-toxicity profile are frequently explored topics, with researchers investigating "green synthesis of halogenated phenols" to align with sustainable chemistry principles.

In summary, 3-Fluoro-5-iodophenol (CAS No. 939771-60-5) bridges multiple scientific disciplines, from pharmaceuticals to advanced materials. Its dual functionality as a fluorine- and iodine-containing scaffold ensures its continued relevance in cutting-edge research. As the industry shifts toward sustainable and efficient synthetic routes, this compound remains a focal point for innovation, answering pressing questions in both academic and industrial settings.

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• 1000574-74-2(3,5-Difluoro-4-iodophenol)
• 2713-29-3(4-Fluoro-2-iodophenol)
• 1167056-58-7(1-Fluoro-3-iodo-5-methoxy-benzene)
• 186589-87-7(5-Fluoro-2-iodophenol)
• 186590-30-7(4,5-Difluoro-2-iodo-phenol)
• 2713-28-2(2-Fluoro-4-iodophenol)
• 122927-84-8(3-Fluoro-4-iodophenol)
• 950858-06-7(2,6-DIFLUORO-4-IODOPHENOL)