Cas no 2713-29-3 (4-Fluoro-2-iodophenol)

4-Fluoro-2-iodophenol is a halogenated phenolic compound featuring both fluorine and iodine substituents on its aromatic ring. This structural configuration imparts unique reactivity, making it a valuable intermediate in organic synthesis, particularly in cross-coupling reactions such as Suzuki or Ullmann couplings. The presence of fluorine enhances electron-withdrawing properties, while the iodine serves as a versatile functional handle for further derivatization. Its applications extend to pharmaceutical and agrochemical research, where it is utilized in the development of bioactive molecules. The compound's stability and well-defined reactivity profile make it a reliable choice for precision synthetic workflows. Proper handling is advised due to its halogenated nature.
4-Fluoro-2-iodophenol structure
4-Fluoro-2-iodophenol structure
Product Name:4-Fluoro-2-iodophenol
CAS No:2713-29-3
MF:C6H4FIO
MW:237.998237609863
MDL:MFCD15527539
CID:1027755
PubChem ID:10171417
Update Time:2025-06-08

4-Fluoro-2-iodophenol Chemical and Physical Properties

Names and Identifiers

    • 4-Fluoro-2-iodophenol
    • 4-Fluoro-2-iodo-phenol
    • 4-Fluor-2-jod-phenol
    • 4-Fluoro-1-hydroxy-2-iodobenzene
    • ANW-53956
    • CTK8B6666
    • FC0669
    • FC0849
    • o-iodophenol
    • SureCN725043
    • 5-Fluoro-2-hydroxyiodobenzene
    • Phenol, 4-fluoro-2-iodo-
    • 2-iodo-4-fluorophenol
    • FTTVHYAABUMDNX-UHFFFAOYSA-N
    • MB14767
    • CM10851
    • AS06581
    • AB0060524
    • Z4529
    • ST24029089
    • 2713-29-3
    • SCHEMBL725043
    • MFCD15527539
    • SY111305
    • DTXSID40436324
    • CS-W008625
    • DS-13715
    • AKOS016000257
    • DB-229099
    • AS-813/43501942
    • MDL: MFCD15527539
    • Inchi: 1S/C6H4FIO/c7-4-1-2-6(9)5(8)3-4/h1-3,9H
    • InChI Key: FTTVHYAABUMDNX-UHFFFAOYSA-N
    • SMILES: IC1C=C(C=CC=1O)F

Computed Properties

  • Exact Mass: 237.92862
  • Monoisotopic Mass: 237.92909g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 9
  • Rotatable Bond Count: 0
  • Complexity: 99.1
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 20.2
  • XLogP3: 2.3

Experimental Properties

  • Density: 2.085
  • Melting Point: 120-123 oC
  • Boiling Point: 196 oC
  • Flash Point: 73 oC
  • PSA: 20.23

4-Fluoro-2-iodophenol Security Information

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4-Fluoro-2-iodophenol Suppliers

Amadis Chemical Company Limited
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(CAS:2713-29-3)4-Fluoro-2-iodophenol
Order Number:A11421
Stock Status:in Stock
Quantity:100g
Purity:99%
Pricing Information Last Updated:Thursday, 29 August 2024 22:54
Price ($):280.0

Additional information on 4-Fluoro-2-iodophenol

Comprehensive Guide to 4-Fluoro-2-iodophenol (CAS No. 2713-29-3): Properties, Applications, and Industry Insights

4-Fluoro-2-iodophenol (CAS No. 2713-29-3) is a halogenated phenolic compound gaining traction in pharmaceutical and agrochemical research due to its unique structural properties. As a fluorinated and iodinated derivative of phenol, it serves as a versatile intermediate in organic synthesis. Its molecular formula, C6H4FIO, and molecular weight of 238.00 g/mol make it a critical building block for cross-coupling reactions, particularly in Suzuki-Miyaura and Buchwald-Hartwig reactions, which are pivotal in drug discovery.

Recent trends in AI-driven drug design and green chemistry have amplified interest in 4-Fluoro-2-iodophenol. Researchers frequently search for "halogenated phenol applications" or "2713-29-3 synthesis methods," reflecting its relevance in optimizing bioactive molecules. The compound’s electron-withdrawing properties enhance reactivity in palladium-catalyzed transformations, a hotspot in medicinal chemistry forums.

From a technical perspective, 4-Fluoro-2-iodophenol exhibits a melting point range of 45–50°C and is typically stored under inert conditions to preserve stability. Its solubility in organic solvents like DMSO and ethanol facilitates its use in high-throughput screening (HTS) workflows. Industry reports highlight its role in developing PET radiotracers, addressing the growing demand for non-invasive diagnostic tools in oncology and neurology.

Environmental and regulatory considerations are also paramount. While not classified as hazardous, its handling requires adherence to REACH and GLP standards. Laboratories prioritize "safe handling of iodophenols" and "2713-29-3 MSDS" queries, underscoring the need for transparent safety data. Innovations in catalytic recycling further align its use with sustainable chemistry goals.

In conclusion, 4-Fluoro-2-iodophenol (CAS No. 2713-29-3) bridges cutting-edge science and industrial practicality. Its applications span drug development, material science, and analytical chemistry, making it a staple in modern R&D. As precision medicine advances, this compound’s role in crafting targeted therapies will only expand, solidifying its niche in the chemical landscape.

Recommended suppliers
Amadis Chemical Company Limited
(CAS:2713-29-3)4-Fluoro-2-iodophenol
A11421
Purity:99%
Quantity:100g
Price ($):280.0
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